Find hotels in Greater South Side, Des Moines

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Our top choices for Greater South Side hotels

Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport
2.0 star property
Greater South Side
8.6 out of 10, Excellent, (1691)
"Had a great stay and was impressed with the staff and the hotel. Will stay again!"
United States
Kevin
The price is ¥9,852
¥11,035 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Days Inn & Suites by Wyndham Des Moines Airport

Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport
2.5 star property
Greater South Side
8.8 out of 10, Excellent, (1002)
"Friendly staff, clean room, comfy bed, and convenient shuttle."
United States
Cullanete
The price is ¥17,055
¥19,102 total
includes taxes & fees
Jan 27 - Jan 28, 2026
Hampton Inn Des Moines-Airport

Quality Inn & Suites Des Moines Airport

Quality Inn & Suites Des Moines Airport
2.5 star property
Greater South Side
7.4 out of 10, Good, (1000)
"Great staff very helpful. "
United States
Cleo and Michaelle
The price is ¥9,824
¥11,003 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Quality Inn & Suites Des Moines Airport

AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport
2.5 star property
Greater South Side
7.8 out of 10, Good, (1003)
"Staff was very helpful."
United States
Ronda
The price is ¥9,703
¥10,867 total
includes taxes & fees
Jan 8 - Jan 9, 2026
AmericInn by Wyndham Des Moines Airport

Holiday Inn Des Moines-Airport/Conf Center by IHG

Holiday Inn Des Moines-Airport/Conf Center by IHG
3.0 star property
Greater South Side
8.2 out of 10, Very Good, (601)
"Beautiful updated room. We had breakfast at the resturant and it was incredible"
United States
Stacy J
The price is ¥19,548
¥21,893 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Holiday Inn Des Moines-Airport/Conf Center by IHG

Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West
2.5 star property
14.9 km from Greater South Side
9.0 out of 10, Wonderful, (1005)
"Room was clean, staff was courteous and the bed was comfortable. "
United States
Craig
The price is ¥11,799
¥13,215 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Fairfield Inn and Suites by Marriott Des Moines West

Holiday Inn Express Des Moines Ankeny by IHG

Holiday Inn Express Des Moines Ankeny by IHG
2.5 star property
17.5 km from Greater South Side
9.4 out of 10, Exceptional, (299)
"clean, friendly staff, room was well equipped"
United States
Colin
The price is ¥13,257
¥14,848 total
includes taxes & fees
Jan 31 - Feb 1, 2026
Holiday Inn Express Des Moines Ankeny by IHG

Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA
2.0 star property
15.3 km from Greater South Side
7.8 out of 10, Good, (725)
"Nice clean room, friendly staff. "
United States
Cheryl
The price is ¥7,974
¥8,931 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Motel 6 West Des Moines, IA

Baymont by Wyndham Des Moines Airport

Baymont by Wyndham Des Moines Airport
2.5 star property
Southwestern Hills, 6.2 km from Greater South Side
9.4 out of 10, Exceptional, (1171)
"Convenient location to restaurants"
United States
Sally
The price is ¥13,425
¥15,035 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Baymont by Wyndham Des Moines Airport

La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA
3.0 star property
18 km from Greater South Side
9.2 out of 10, Wonderful, (1000)
"Great stay with dogs"
United States
Mindy
The price is ¥12,526
¥14,030 total
includes taxes & fees
Jan 1 - Jan 2, 2026
La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

Hampton Inn & Suites Altoona-Des Moines

Hampton Inn & Suites Altoona-Des Moines
2.5 star property
18.8 km from Greater South Side
9.2 out of 10, Wonderful, (675)
"Great place to stay!"
United States
Donald J
The price is ¥15,388
¥17,234 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hampton Inn & Suites Altoona-Des Moines

Country Inn & Suites by Radisson, Indianola, IA

Country Inn & Suites by Radisson, Indianola, IA
2.5 star property
19.7 km from Greater South Side
9.0 out of 10, Wonderful, (716)
"I stay at this property multiple times a year and have always had a positive experience. "
United States
John
The price is ¥16,482
¥18,459 total
includes taxes & fees
Jan 24 - Jan 25, 2026
Country Inn & Suites by Radisson, Indianola, IA

Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University
3.0 star property
Drake, 5.6 km from Greater South Side
9.4 out of 10, Exceptional, (1011)
"Great place to stay and the employees were super nice and helpful"
United States
Amy
The price is ¥14,618
¥16,372 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Home2 Suites by Hilton Des Moines at Drake University

Drury Inn & Suites West Des Moines

Drury Inn & Suites West Des Moines
3.0 star property
12.3 km from Greater South Side
9.4 out of 10, Exceptional, (1000)
"A great place to stay"
United States
Carol
The price is ¥15,595
¥17,467 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Drury Inn & Suites West Des Moines

Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG
3.0 star property
Historic East Village, 4.5 km from Greater South Side
9.4 out of 10, Exceptional, (1000)
"Staff was amazing. Room, pool, breakfast all spectacular. Enjoyed our stay. Will tell our friends and family and will come back "
United States
Amanda
The price is ¥13,918
¥15,588 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Staybridge Suites Des Moines Downtown by IHG

Courtyard Marriott Ankeny

Courtyard Marriott Ankeny
3.0 star property
17.9 km from Greater South Side
8.8 out of 10, Excellent, (541)
"Location, easy check in, welcoming vibe. "
United States
Denise
The price is ¥13,125
¥14,699 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Courtyard Marriott Ankeny

Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG
2.5 star property
Downtown Des Moines, 3.2 km from Greater South Side
9.2 out of 10, Wonderful, (979)
"Great room, good breakfast. "
United States
Jason
The price is ¥13,918
¥15,588 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express & Suites Des Moines Downtown by IHG

Hampton Inn West Des Moines Lake Drive

Hampton Inn West Des Moines Lake Drive
3.0 star property
14.9 km from Greater South Side
9.0 out of 10, Wonderful, (1003)
"Easy friendly check in. "
United States
Lisa
The price is ¥13,336
¥14,937 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Hampton Inn West Des Moines Lake Drive

Comfort Inn & Suites West Des Moines

Comfort Inn & Suites West Des Moines
2.5 star property
15.2 km from Greater South Side
8.8 out of 10, Excellent, (576)
"Convenient location"
United States
Todd
The price is ¥12,914
¥14,464 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Comfort Inn & Suites West Des Moines

La Quinta Inn & Suites by Wyndham Des Moines West Clive

La Quinta Inn & Suites by Wyndham Des Moines West Clive
3.0 star property
13.3 km from Greater South Side
8.6 out of 10, Excellent, (1005)
"Very clean with a great breakfast. My kiddos loved the pool!"
United States
Erica
The price is ¥11,100
¥12,432 total
includes taxes & fees
Jan 25 - Jan 26, 2026
La Quinta Inn & Suites by Wyndham Des Moines West Clive
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Greater South Side

Find the best Greater South Side areas and neighborhoods for the activities you enjoy most. Learn more about Greater South Side
Learn more about Greater South Side

Downtown Des Moines

Downtown Des Moines boasts corporate campuses, fine dining, and unique retail destinations. Explore the Pappajohn Sculpture Park, and enjoy easy access to DART transit and skywalk connections.

Historic East Village

Directly east of Downtown Des Moines, this nationally recognized historic district boasts the Iowa State Capitol complex, State of Iowa Historical Museum, and Des Moines Botanical Gardens. Explore eateries, boutique shops, and loft-style housing in its charming structures.

Court District

Court District is known for its ample dining options, and you can make a stop by Science Center of Iowa and Principal Park while in the area.

Drake

If you're spending some time in Drake, Knapp Center and Des Moines Community Playhouse are top sights worth seeing.

Southwestern Hills

While Southwestern Hills might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Air Lanes Bowling Center and Gray’s Lake Park.

Top Greater South Side Hotel Reviews

Frequently asked questions

What's it like in Greater South Side?
Travelers are sure to enjoy a stay in Des Moines's Greater South Side neighborhood. Consider a visit to Gray's Lake Park as part of your Greater South Side travel plans.
What's a favorite place to stay in Greater South Side?
Based on Expedia customer reviews, Days Inn & Suites by Wyndham Des Moines Airport is the highest ranked property in Greater South Side. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include Hampton Inn Des Moines-Airport and AmericInn by Wyndham Des Moines Airport.
How many hotels will I be able to find in Greater South Side?
With 16 Expedia hotels and other accommodations in Greater South Side to choose from, this is a good starting point for exploring the greater Des Moines area.
If I need to cancel my hotel reservation in Greater South Side, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get top deals in Greater South Side.
Where can I learn more about changing or cancelling my trip to Greater South Side?
For more information about changing or cancelling your trip to Greater South Side, head over to our customer service page.
What is there to do around this Des Moines neighborhood?
Gray's Lake Park is an attraction you might want to check out while you're in Greater South Side. While you're out sightseeing, Air Lanes Bowling Center and Lauridsen Amphitheater are a couple of additional sights to visit in Des Moines.

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