Find hotels near Duke Regional Hospital, Raleigh from ￥11,331

"The room was clean and the staff were welcoming and helpful! Thanks so much for a relaxing stay."

"No other hotels in this area is this exceptional with comfortable modern rooms, decent breakfast menu and a proper welcome entrance."

"Easy check in, clean room"

"Nice clean room, beautiful view over the pool and city center, staff was friendly, and it was centrally located to plenty of good restaurants, shopping, and the Carolina Theatre. Will definitely stay again!"

"This hotel is our favorite pet-friendly hotel in downtown Durham. During this last visit, I had inadvertently double booked myself a room directly with the hotel and on Expedia. The check-in host was so kind to cancel the room booked directly with the hotel without penalties. I certainly was not expecting that and figured I'd be paying for two rooms due to my oversight. Thank you 21c hotel. That made my day, and I will certainly return. "

"We stayed here for NYE/New Year's Day, and the front desk team was incredible. They were personable, energetic, responsive, and kind. The Suite is a great choice for a stay--it's spacious and perfectly situated in the hotel. What a great place to close out 2025 and ring in 2026!"

"Quiet home in Durham"

"The house had everything we needed for the long weekend for our family and kiddos. The kitchen was well stocked with equipment, and we greatly appreciated the fenced in backyard and outdoor seating for some spectacular late-summer mornings. The neighborhood is quiet, but close to both university campuses and plenty of excellent restaurants and activities."