Find Resorts & Hotels with Spas in Downtown Louisville, KY

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Check availability on Downtown Louisville Resorts & Hotels with Spas

Our top choices for Downtown Louisville hotels with a spa

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3848)
"Beautiful room and great hospitality. "
United States
Chase
The price is ￥20,727
￥24,388 total
includes taxes & fees
Dec 16 - Dec 17
Galt House Hotel Trademark Collection by Wyndham
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1002)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is ￥21,613
￥26,206 total
includes taxes & fees
Jan 7 - Jan 8, 2026
21c Museum Hotel Louisville
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1726)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is ￥25,999
￥30,591 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Omni Louisville Hotel
Full-size fridge, microwave, oven, stovetop
The Reserve on Main

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
The price is ￥22,546
￥33,945 total
includes taxes & fees
Dec 30 - Dec 31
The Reserve on Main
Indoor pool
Caesars Southern Indiana - A Caesars Rewards Destination

Caesars Southern Indiana - A Caesars Rewards Destination

Caesars Southern Indiana - A Caesars Rewards Destination
3.5 star property
Elizabeth
8.2 out of 10, Very Good, (1002)
"The room was very clean, the staff was very friendly and helpful."
United States
Judy
The price is ￥13,839
￥18,471 total
includes taxes & fees
Dec 14 - Dec 15
Caesars Southern Indiana - A Caesars Rewards Destination
Exterior detail
Central Park Bed & Breakfast

Central Park Bed & Breakfast

Central Park Bed & Breakfast
4.0 star property
Old Louisville
9.4 out of 10, Exceptional, (57)
"Our stay here was excellent in every way! The owners were very sweet and went out of their way to assist us in every way, the rooms were very cozy, and the breakfasts were fantastic. This is the best B&B we've ever stayed."
United States
John
The price is ￥19,187
￥22,270 total
includes taxes & fees
Dec 15 - Dec 16
Central Park Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Downtown Louisville Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"Clean room, safe parking, and we love the bar! "
julie 1-night trip
Posted 2 days ago
Galt House Hotel Trademark Collection by Wyndham
21c Museum Hotel Louisville

21c Museum Hotel Louisville

10/10 Excellent
"Yes "
Briana 1-night trip
Posted 4 days ago
21c Museum Hotel Louisville

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Frequently asked questions

Looking for a spa hotel in Downtown Louisville?
Forget the stress of everyday life and book yourself a hotel with a spa. Travelers love the restaurants and bars in Downtown Louisville. Enjoy the live music and riverfront during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Downtown Louisville?
Galt House Hotel Trademark Collection by Wyndham is a top spa hotel featuring 4 restaurants, a fitness center, a hair salon, and a bar. Spend an afternoon at the spa where you'll find deep-tissue massages, hot stone massages, and mani/pedis. In-room massages are also available. Other popular spa hotels in Downtown Louisville include Omni Louisville Hotel and 21c Museum Hotel Louisville.
How many spa hotels will I find in Downtown Louisville?
Among Expedia's 370 accommodation options in Downtown Louisville, there are 3 spa hotels.
What's there to see and do in Downtown Louisville?
Take in the sights and attractions that Downtown Louisville offers with a visit to Whiskey Row, KFC Yum Center, and Fourth Street Live!. If you have a little extra time during your trip, you might want to check out Belle of Louisville and Louisville Palace.
What is a Downtown Louisville spa hotel?
Spa hotels in Downtown Louisville provide lodging and have an on-site spa offering services like couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.