The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A wooden staircase with a balustrade leading to a landing.

A brick building with a covered porch, columns, and potted plants.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

A two-story brick building with a white porch and a sign reading "Hotel".

1. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

￥34,943

￥39,486 total

includes taxes & fees

Oct 20 - Oct 21

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

2. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥25,619

￥29,735 total

includes taxes & fees

Nov 19 - Nov 20

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

3. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

￥36,016

￥42,376 total

includes taxes & fees

Nov 8 - Nov 9

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

4. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

John

￥19,800

￥23,298 total

includes taxes & fees

Oct 28 - Oct 29

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A swimming pool with lounge chairs and a view of the city.

5. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

peter

￥18,529

￥21,801 total

includes taxes & fees

Oct 27 - Oct 28

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

6. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥18,273

￥29,464 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

7. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥18,789

￥22,107 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A lobby with a marble floor, a reception desk, and a large chandelier.

A modern interior with a fireplace, bookshelves, and seating areas.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

8. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Kristan

￥32,110

￥37,780 total

includes taxes & fees

Nov 16 - Nov 17

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

9. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

￥24,611

￥28,958 total

includes taxes & fees

Nov 15 - Nov 16

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

10. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥24,043

￥29,079 total

includes taxes & fees

Nov 9 - Nov 10

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

11. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Sarah

￥16,308

￥19,188 total

includes taxes & fees

Nov 9 - Nov 10

A covered patio with a stone wall, a glass table, and a bench.

A grand room with a fireplace, a staircase, and a chandelier.

A garden pathway with a lantern, potted plants, and a white fence.

12. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

￥24,018

￥27,878 total

includes taxes & fees

Oct 25 - Oct 26

A brick building with outdoor seating and a fire pit.

A modern restaurant with wooden furniture, a central island, and a high ceiling.

A modern hotel room with a sofa, a small desk, a microwave, and a TV.

A modern bar area with a wooden counter, bar stools, and a variety of bottles and glasses.

13. TownePlace Suites by Marriott Louisville North

2.2 km from 21c Museum Hotel

Lori M

￥23,387

￥26,427 total

includes taxes & fees

Oct 29 - Oct 30

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

14. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Anthony

￥20,721

￥24,380 total

includes taxes & fees

Nov 15 - Nov 16

A brightly lit grocery store with yellow shelving and a central checkout counter.

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A bedroom with a bed, a chair, a TV, and a window with curtains.

15. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

￥23,229

￥27,332 total

includes taxes & fees

Nov 8 - Nov 9

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

16. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

￥18,962

￥22,310 total

includes taxes & fees

Nov 15 - Nov 16

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

17. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,613

￥26,606 total

includes taxes & fees

Oct 30 - Oct 31

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A balcony with a view of a river, a bridge, and a cityscape.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

18. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Judy

￥22,156

￥26,070 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A modern hotel room with a living area, a dining area, and a bedroom.

A hotel dining area with long tables, booths, and a bar.

19. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Frances

￥20,603

￥24,242 total

includes taxes & fees

Nov 15 - Nov 16

A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.

A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.

A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.

A modern bar area with glass partitions, bar stools, and a variety of bottles.

20. Louisville Marriott Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

Jason

￥31,120

￥36,616 total

includes taxes & fees

Nov 13 - Nov 14

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Market Street Inn	9.8 Exceptional 125 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 150 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 511 reviews	View
The Brown Hotel	9.4 Exceptional 1,397 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	9.4 Exceptional 1,007 reviews	View

Top 21c Museum Hotel Hotel Reviews

The Grady

10/10 Excellent

"Lovely boutique hotel. Great location, very nice staff. Only issue was trying to get into on-site restaurant which was always booked up."

The Brown Hotel

10/10 Excellent

"Excellent as usual"

Cambria Hotel Louisville Downtown-Whiskey Row

8/10 Good

"Very clean . Friendly staff . Great location"

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent

"Nice location, a good walk to most sights but at the most it was a 10+ minute walk to Mahammad Ali Museum, Whiskey Row, 4th Street Live and the Derby City Gaming downtown. We felt safe walking together day and night; saw a few homeless people and yes I was asked once for money but never felt unsafe. When we arrived, we immediately saw the Holiday Inn Express sign to park at the parking garage next to the hotel. But first, drive past that and leave your luggage at the hotel if you have a lot to carry! Then park, then check in and tell the front desk staff that you’re already parked, they will add $21 a day to your room and give you a paper with a QR code to scan to come & go in the parking lot. Check-in for some took a while, but the gentleman that checked us in was fast and efficient! The hotel is pretty, and the breakfast was very good with a lot of seating. There's a small market near the front desk for food, alcohol, drinks, etc -but no price list on the wall and nowhere does it say but you can't charge anything to your room. "Corporate Policy", we were told. Cash and credit card only. No signs telling you this though. In fairness, items we bought were reasonably priced. There's an easy remedy - signs. Future guests will thank you. As for the room, our king bedroom was big, the bed was very comfortable. Great lighting in bathroom! Keurig in the room. We loved it, really!"

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"The room was very clean and well laid out. The young lady who checked us in was especially nice and helpful."

Omni Louisville Hotel

8/10 Good

"This is a nice hotel and a bit pricey at times. The only place for dinner here is a very expensive steak restaurant. The other restaurant in this hotel serves breakfast and lunch only. A bit disappointing when you’re planning to stay in due to weather conditions. Has other enmities throughout the hotel worth seeking out."

Louisville Marriott Downtown

10/10 Excellent

"We really enjoyed our stay here. The hotel is centrally located and convenient to explore different areas of the city. The fitness center and studio spaces are large and top of the line. Our room was incredibly quiet and private."

Holiday Inn Louisville Downtown by IHG

8/10 Good

"great location for conference.. clean and functional."

21c Museum Hotel Louisville

10/10 Excellent

"Unique hotel with character. There's a museum inside and they provide you with a free bourbon sample to tour it. And the PENGUINS. Everywhere there are 3' tall red plastic penguins that seem to move around the hotel. What a fun idea. Woke up to one in front of our door one morning. Great staff!!! So helpful and great to talk to. Everyone from the doorman to the front desk and bar staff. Also loved the bar! Cici was amazing!"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

1. Market Street Inn

2. DuPont Mansion Bed & Breakfast

3. Hotel Distil, Autograph Collection

4. The Brown Hotel

5. Homewood Suites by Hilton Louisville Downtown, KY

6. Stellar Suites

7. Tempo By Hilton Louisville Downtown Nulu

8. Omni Louisville Hotel

9. The Grady

10. 21c Museum Hotel Louisville

11. Cambria Hotel Louisville Downtown-Whiskey Row

12. Central Park Bed & Breakfast

13. TownePlace Suites by Marriott Louisville North

14. Aloft by Marriott Louisville Downtown

15. Hotel Genevieve part of JdV by Hyatt

16. Moxy Louisville Downtown

17. AC Hotel Louisville Downtown

18. Galt House Hotel Trademark Collection by Wyndham

19. Embassy Suites Louisville Downtown

20. Louisville Marriott Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

The Grady

The Brown Hotel

Cambria Hotel Louisville Downtown-Whiskey Row

Holiday Inn Express & Suites Louisville Downtown by IHG

Towneplace Suites By Marriott Louisville Downtown

Omni Louisville Hotel

Louisville Marriott Downtown

Holiday Inn Louisville Downtown by IHG

21c Museum Hotel Louisville

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

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