The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A wooden staircase with a balustrade leading to a landing.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A brick building with a covered porch, columns, and potted plants.

1. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

￥34,961

￥39,506 total

includes taxes & fees

Oct 18 - Oct 19

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

2. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

￥36,034

￥42,398 total

includes taxes & fees

Nov 8 - Nov 9

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥28,799

￥33,428 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A lobby with a marble floor, a reception desk, and a large chandelier.

4. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Samantha

￥19,826

￥23,328 total

includes taxes & fees

Oct 18 - Oct 19

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

A swimming pool with lounge chairs and a view of the city.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

5. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Kelly

￥19,114

￥22,490 total

includes taxes & fees

Nov 8 - Nov 9

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, large windows, and classic furniture.

6. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

John

￥19,811

￥23,311 total

includes taxes & fees

Oct 28 - Oct 29

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

7. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥19,317

￥22,729 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

8. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥15,483

￥26,229 total

includes taxes & fees

Oct 27 - Oct 28

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

9. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

￥23,596

￥27,764 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern hotel room with a large bed, a city view, and a unique headboard design.

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Cameron

￥28,392

￥33,406 total

includes taxes & fees

Oct 25 - Oct 26

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

11. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥24,053

￥29,092 total

includes taxes & fees

Nov 8 - Nov 9

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

12. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Dolores

￥15,557

￥18,305 total

includes taxes & fees

Oct 18 - Oct 19

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

13. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

￥13,184

￥15,512 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor seating area with wicker furniture and a fire pit.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

A modern lounge area with seating, tables, and a view of the city through large windows.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

14. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Derek

￥15,336

￥18,044 total

includes taxes & fees

Nov 8 - Nov 9

A modern bar area with a circular bar, multiple seating options, and a large screen.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

15. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Sarah

￥15,965

￥18,783 total

includes taxes & fees

Oct 25 - Oct 26

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A brightly lit grocery store with yellow shelving and a central checkout counter.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

16. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

￥21,344

￥25,114 total

includes taxes & fees

Oct 25 - Oct 26

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

17. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,624

￥26,620 total

includes taxes & fees

Oct 25 - Oct 26

A covered patio with a stone wall, a glass table, and a bench.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A garden pathway with a lantern, potted plants, and a white fence.

18. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

￥24,029

￥27,891 total

includes taxes & fees

Oct 25 - Oct 26

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A balcony with a view of a river, a bridge, and a cityscape.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

19. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Mark

￥22,167

￥26,081 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

A hotel dining area with long tables, booths, and a bar.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A modern hotel room with a living area, a dining area, and a bedroom.

20. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Frances

￥20,613

￥24,252 total

includes taxes & fees

Nov 15 - Nov 16

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Market Street Inn	9.8 Exceptional 125 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 510 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 150 reviews	View
Omni Louisville Hotel	9.4 Exceptional 2,190 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	9.4 Exceptional 1,002 reviews	View

Top 21c Museum Hotel Hotel Reviews

21c Museum Hotel Louisville

10/10 Excellent

"Unique hotel with character. There's a museum inside and they provide you with a free bourbon sample to tour it. And the PENGUINS. Everywhere there are 3' tall red plastic penguins that seem to move around the hotel. What a fun idea. Woke up to one in front of our door one morning. Great staff!!! So helpful and great to talk to. Everyone from the doorman to the front desk and bar staff. Also loved the bar! Cici was amazing!"

The Brown Hotel

10/10 Excellent

"Stay frequently. Just make sure to make reservations in the dining room incl breakfast or call room service."

Moxy Louisville Downtown

10/10 Excellent

"I had a nice stay and would recommend staying here"

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"We had an amazing stay!! The place was clean and nice and breakfast was super convenient in the mornings. I think the only negative thing was that the fridge was really loud at night and then it stopped working the next day. Other than that, amazing place. The best thing was for sure the staff. Everyone was super sweet and welcoming. They gave us lots of recommendations to do around the city. Absolutely recommend."

The Grady

10/10 Excellent

"The location, history and ambience were wonderful."

Louisville Marriott Downtown

8/10 Good

"room was very clean but the there were additional blankets provided"

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent

"Great location- super responsive host - clean and great view of the river."

The PRES@The 713! Penthouse Suite with private rooftop patio, on Bourbon Trail!

10/10 Excellent

"Wonderful experience from making the reservation until the end of our stay. Great communication with the hosts. And enjoyed the location and the loft was very comfortable."

Bluegrass River View! Soak & Savor by Hollyhock

10/10 Excellent

"Thank you for hosting us. Our boys basketball team used this as home base with 2 dad's and 4 kids staying here. Everyone had a blast and enjoyed the view."

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Find hotels near 21c Museum Hotel, Louisville from ￥15,512

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Treat yourself

Be picky

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Our top choices for 21c Museum Hotel hotels

1. Market Street Inn

2. Hotel Distil, Autograph Collection

3. DuPont Mansion Bed & Breakfast

4. Omni Louisville Hotel

5. Homewood Suites by Hilton Louisville Downtown, KY

6. The Brown Hotel

7. Tempo By Hilton Louisville Downtown Nulu

8. Stellar Suites

9. The Grady

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

11. 21c Museum Hotel Louisville

12. Aloft by Marriott Louisville Downtown

13. Moxy Louisville Downtown

14. Towneplace Suites By Marriott Louisville Downtown

15. Cambria Hotel Louisville Downtown-Whiskey Row

16. Hotel Genevieve part of JdV by Hyatt

17. AC Hotel Louisville Downtown

18. Central Park Bed & Breakfast

19. Galt House Hotel Trademark Collection by Wyndham

20. Embassy Suites Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

21c Museum Hotel Louisville

The Brown Hotel

Moxy Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

The Grady

Louisville Marriott Downtown

Suite 7 City Loft Escape with River Views! By Hollyhock

The PRES@The 713! Penthouse Suite with private rooftop patio, on Bourbon Trail!

Bluegrass River View! Soak & Savor by Hollyhock

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

Explore a world of travel with Expedia