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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.
A covered outdoor seating area with wicker furniture and a wooden railing.
A living room with a sofa, armchair, coffee table, fireplace, and large windows.

1. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Roy
￥44,176
￥51,275 total
includes taxes & fees
Oct 19 - Oct 20
Louisville Bourbon Inn
A wooden staircase with a balustrade leading to a landing.
A bedroom with a bed, a dresser, a television, and a desk with a lamp.
A dining area with brick walls, wooden shelves, and tables set for a meal.
A two-story brick building with a white porch and a sign reading "Hotel".

2. Market Street Inn

Market Street Inn
2.1 km from 21c Museum Hotel
United States
Holly
￥31,033
￥35,067 total
includes taxes & fees
Oct 26 - Oct 27
Market Street Inn
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A spacious lobby with a large seating area, a chandelier, and a patterned rug.
A swimming pool with lounge chairs and a view of the city.
A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

3. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Kelly
￥15,296
￥17,996 total
includes taxes & fees
Oct 28 - Oct 29
Homewood Suites by Hilton Louisville Downtown, KY
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.
An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.
A living room with a sofa, a fireplace, a staircase, and a chandelier.

4. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Casey
￥22,616
￥26,249 total
includes taxes & fees
Nov 4 - Nov 5
DuPont Mansion Bed & Breakfast
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.
An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.
A bar with shelves of liquor bottles and a bartender preparing drinks.

5. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Heather
￥37,482
￥44,102 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Distil, Autograph Collection
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

6. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
John
￥19,841
￥23,345 total
includes taxes & fees
Oct 29 - Oct 30
The Brown Hotel
A modern bar area with a circular bar, multiple seating options, and a large screen.
A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.
A modern lobby with a fireplace, seating area, and a reception desk.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

7. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Gordon
￥16,122
￥18,970 total
includes taxes & fees
Oct 25 - Oct 26
Cambria Hotel Louisville Downtown-Whiskey Row
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A lobby with a marble floor, a reception desk, and a large chandelier.

8. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Samantha
￥19,857
￥23,364 total
includes taxes & fees
Oct 18 - Oct 19
Omni Louisville Hotel
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A building with a sign reading "THE GRADY" at the entrance.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

9. The Grady

The Grady
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Donna
￥25,854
￥30,419 total
includes taxes & fees
Oct 25 - Oct 26
The Grady
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.
A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

10. Stellar Suites

Stellar Suites
East Market District, 2.2 km from 21c Museum Hotel
United States
Kevin
￥18,311
￥29,523 total
includes taxes & fees
Oct 18 - Oct 19
Stellar Suites
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".
A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.
A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

11. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 2 km from 21c Museum Hotel
United States
Addison
￥19,346
￥22,763 total
includes taxes & fees
Oct 25 - Oct 26
Tempo By Hilton Louisville Downtown Nulu
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A steam fountain in a brick alleyway.

12. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 km from 21c Museum Hotel
United States
Matt
￥24,090
￥29,137 total
includes taxes & fees
Nov 8 - Nov 9
21c Museum Hotel Louisville
An outdoor seating area with wicker furniture and a fire pit.
A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.
An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.
A modern living room with a sofa, armchairs, a coffee table, and a TV.

13. Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
Downtown Louisville, 0.3 km from 21c Museum Hotel
United States
Barbara
￥15,359
￥18,072 total
includes taxes & fees
Nov 8 - Nov 9
Towneplace Suites By Marriott Louisville Downtown
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

14. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Cameron
￥28,435
￥33,456 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A cozy living room with a fireplace, a black leather sofa, and a patterned rug.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.
A modern living room with a sofa, ottomans, a coffee table, and a rug.

15. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Alicia
￥14,156
￥16,656 total
includes taxes & fees
Oct 18 - Oct 19
Moxy Louisville Downtown
An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.
A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.
A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.
A modern bar area with sofas, tables, and a bar stocked with bottles.

16. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Dolores
￥14,630
￥17,213 total
includes taxes & fees
Nov 8 - Nov 9
Aloft by Marriott Louisville Downtown
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.
A brightly lit grocery store with yellow shelving and a central checkout counter.
A bedroom with a bed, a chair, a TV, and a window with curtains.

17. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 2 km from 21c Museum Hotel
United States
Tyler
￥22,844
￥26,879 total
includes taxes & fees
Oct 26 - Oct 27
Hotel Genevieve part of JdV by Hyatt
A covered patio with a stone wall, a glass table, and a bench.
A grand room with a fireplace, a staircase, and a chandelier.
A stone house with a balcony, a front door, and a staircase leading to the entrance.
Staircase

18. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 2.9 km from 21c Museum Hotel
United States
Nicole
￥24,066
￥27,934 total
includes taxes & fees
Oct 25 - Oct 26
Central Park Bed & Breakfast
A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.
A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.
A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.
A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

19. AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
East Market District, 2 km from 21c Museum Hotel
United States
Jen
￥22,658
￥26,659 total
includes taxes & fees
Oct 25 - Oct 26
AC Hotel Louisville Downtown
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A balcony with a view of a river, a bridge, and a cityscape.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

20. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from 21c Museum Hotel
United States
Mark
￥22,917
￥26,965 total
includes taxes & fees
Oct 30 - Oct 31
Galt House Hotel Trademark Collection by Wyndham
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Compare popular hotels close to 21c Museum Hotel

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
Louisville Bourbon Inn
10.0
Exceptional
25 reviews
View
A wooden staircase with a balustrade leading to a landing.
Market Street Inn
9.8
Exceptional
125 reviews
View
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
Homewood Suites by Hilton Louisville Downtown, KY
9.4
Exceptional
1,000 reviews
View
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
149 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
510 reviews
View

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

The Brown Hotel

10/10 Excellent
"Beautiful hotel with wonderful history and the staff is very friendly. We noticed many of the staff have worked there for years and have a strong sense of pride in the hotel. They love to share the history of the hotel and show off the beautiful rooms. I recommend you have a drink at the bar and of course the Hot Brown is a must to complete your stay."
Debra 1-night trip
Posted 1 hour ago
The Brown Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

10/10 Excellent
"Location is great. Staff is helpful. It’s clean and comfortable. Great breakfast every morning too. A few bottles of water in the room would have been nice but overall very happy with our stay and would come back."
Josh J 3-night trip
Posted 2 hours ago
Embassy Suites Louisville Downtown
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good
"Breakfast was great. Wonderful options and perfect temperature. The hotel is convenient to whiskey row and the Louisville Slugger museum."
Michael 1-night trip
Posted 2 hours ago
Holiday Inn Express & Suites Louisville Downtown by IHG
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent
"Attending a conference that was being held at a separate location, I appreciated the location, attention, safety, and accessibility to the city that was provided."
Stephen 3-night trip
Posted 2 hours ago
Towneplace Suites By Marriott Louisville Downtown
21c Museum Hotel Louisville

21c Museum Hotel Louisville

10/10 Excellent
"This was our second stay here and will stay again when in town. Very cool place if you like art. Great service. Nice room but nothing really special about it. Super convenient location downtown on Main Street, walking distance to many attractions and distilleries. Very good on-site restaurant/bar."
Michael 3-night trip
Posted 23 hours ago
21c Museum Hotel Louisville
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent
"The staff were very helpful & great location."
Ana 1-night trip
Posted 1 day ago
Cambria Hotel Louisville Downtown-Whiskey Row
Louisville Marriott Downtown

Louisville Marriott Downtown

8/10 Good
"room was very clean but the there were additional blankets provided"
Mary Francis 2-night trip
Posted 1 day ago
Louisville Marriott Downtown
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent
"Very comfortable place to stay and all the team was very nice!"
Kathryn 4-night trip
Posted 2 days ago
Homewood Suites by Hilton Louisville Downtown, KY
Suite 7 City Loft Escape with River Views! By Hollyhock

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent
"Great location- super responsive host - clean and great view of the river."
Jim M. 3-night trip
Posted 2 weeks ago
Suite 7 City Loft Escape with River Views! By Hollyhock

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)
Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
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The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.
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Evan Williams Bourbon Experience

8.6/10 (20 reviews)
You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
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Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.
What's the best place to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.
How many hotels will I find close to 21c Museum Hotel?
Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.
Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?
For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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