The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A covered outdoor seating area with wicker furniture and a wooden railing.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥44,168

￥51,267 total

includes taxes & fees

Oct 12 - Oct 13

A wooden staircase with a balustrade leading to a landing.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A brick building with a covered porch, columns, and potted plants.

A two-story brick building with a white porch and a sign reading "Hotel".

2. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

￥30,969

￥34,995 total

includes taxes & fees

Oct 12 - Oct 13

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

A bar with shelves of liquor bottles and a bartender preparing drinks.

3. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Anthony

￥37,475

￥44,093 total

includes taxes & fees

Oct 29 - Oct 30

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

4. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

John

￥19,837

￥23,341 total

includes taxes & fees

Oct 28 - Oct 29

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

5. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥22,611

￥26,244 total

includes taxes & fees

Nov 4 - Nov 5

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

6. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Gordon

￥17,097

￥20,117 total

includes taxes & fees

Nov 9 - Nov 10

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A swimming pool with lounge chairs and a view of the city.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

7. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Kelly

￥18,183

￥21,394 total

includes taxes & fees

Nov 11 - Nov 12

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A building with a sign reading "THE GRADY" at the entrance.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

8. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

￥25,858

￥30,425 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

9. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥21,138

￥24,870 total

includes taxes & fees

Oct 29 - Oct 30

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

10. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥18,308

￥29,519 total

includes taxes & fees

Oct 18 - Oct 19

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

11. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥24,085

￥29,130 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern hotel room with a large bed, a city view, and a unique headboard design.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

12. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Cameron

￥28,429

￥33,449 total

includes taxes & fees

Oct 18 - Oct 19

A covered patio with a stone wall, a glass table, and a bench.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A garden pathway with a lantern, potted plants, and a white fence.

13. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Brittany

￥24,061

￥27,928 total

includes taxes & fees

Oct 14 - Oct 15

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A modern interior with a fireplace, bookshelves, and seating areas.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

14. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Samantha

￥40,211

￥47,313 total

includes taxes & fees

Oct 30 - Oct 31

An outdoor seating area with wicker furniture and a fire pit.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.

15. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Barbara

￥17,414

￥20,490 total

includes taxes & fees

Oct 25 - Oct 26

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

16. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Dolores

￥20,759

￥24,426 total

includes taxes & fees

Nov 8 - Nov 9

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

17. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

￥20,264

￥23,842 total

includes taxes & fees

Oct 25 - Oct 26

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

18. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,654

￥26,655 total

includes taxes & fees

Oct 25 - Oct 26

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A brightly lit grocery store with yellow shelving and a central checkout counter.

19. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

￥22,797

￥26,823 total

includes taxes & fees

Nov 8 - Nov 9

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A balcony with a view of a river, a bridge, and a cityscape.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Phillip

￥22,869

￥26,907 total

includes taxes & fees

Oct 27 - Oct 28

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 125 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 509 reviews	View
The Brown Hotel	9.4 Exceptional 1,359 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 149 reviews	View

Top 21c Museum Hotel Hotel Reviews

Omni Louisville Hotel

10/10 Excellent

"Beautiful property, great location"

Galt House Hotel Trademark Collection by Wyndham

8/10 Good

"Centrally located in downtown Louisville. Walking distance to many sites and well narrated property.. elevator traffic at lunch time as bit rough with conventions in town."

Holiday Inn Louisville Downtown by IHG

8/10 Good

"Helpful and friendly staff. The hotel was clean, but the carpet could use some attention."

Embassy Suites Louisville Downtown

10/10 Excellent

"Leading up to the trip communication was amazing. I thought the staff at the desk was pleasant & helpful. And the hotel is beautiful & clean. Our only complaint was the shuttle. We followed the information provided for using it & were told upon arrival at the airport that we would need to wait as the driver had to leave due to “a pilot pick up”. We didn’t understand but at that point we waited an additional 45 minutes to get transportation back to the hotel. At the end of our stay we checked at the desk & again at the transportation station to assure our return to the airport would be on time. We planned for additional time to be able to allow for any delays & checked in at the transportation station at 1:45pm for the 2:05pm shuttle- after numerous conversations with staff & waiting for “the pilots” we were told “the pilots are the priority.” We finally left for the airport at 2:45 but had to go to UPS first. We made our flight but it took a hussle to do so. While we understand business & partnerships- maybe it would be better to not provide an hourly scheduled shuttle service. We booked specifically because this hotel offered that amenity. If it’s not available, just don’t offer it to customers. And you certainly shouldn’t tell your customers that they are not your priority."

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good

"Great location in downtown Louisville. Close to Whiskey Row and many restaurants. We did not have a car so did not use parking. Breakfast was fine for a free hotel breakfast. Had a light bulb that was out and they promote put a new one in. Room size was great."

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"Great hotel!"

Towneplace Suites By Marriott Louisville Downtown

8/10 Good

"Staff were great. Breakfast was good. Only is was the fan in the bathroom. It had a banging noise coming from it and if you left the door open it would keep you awake."

The Reserve on Main

10/10 Excellent

"All good."

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent

"The location is excellent for the price, and the unit was clean and perfect for crashing after a night out. Host is responsive and fixed a door issue we had in almost no time at all. Would definitely recommend for a long weekend in Louisville!"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Treat yourself

Be picky

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. Hotel Distil, Autograph Collection

4. The Brown Hotel

5. DuPont Mansion Bed & Breakfast

6. Cambria Hotel Louisville Downtown-Whiskey Row

7. Homewood Suites by Hilton Louisville Downtown, KY

8. The Grady

9. Tempo By Hilton Louisville Downtown Nulu

10. Stellar Suites

11. 21c Museum Hotel Louisville

12. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

13. Central Park Bed & Breakfast

14. Omni Louisville Hotel

15. Towneplace Suites By Marriott Louisville Downtown

16. Aloft by Marriott Louisville Downtown

17. Moxy Louisville Downtown

18. AC Hotel Louisville Downtown

19. Hotel Genevieve part of JdV by Hyatt

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Omni Louisville Hotel

Galt House Hotel Trademark Collection by Wyndham

Holiday Inn Louisville Downtown by IHG

Embassy Suites Louisville Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

Cambria Hotel Louisville Downtown-Whiskey Row

Towneplace Suites By Marriott Louisville Downtown

The Reserve on Main

Suite 7 City Loft Escape with River Views! By Hollyhock

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

Explore a world of travel with Expedia