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Sep 25 - Sep 26
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Sep 26 - Sep 27
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Sep 25 - Sep 27
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Oct 2 - Oct 4

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Our top choices for 21c Museum Hotel hotels

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
A room with a red velvet sofa, a blue armchair, and a small round table with books.
A living room with a sofa, a fireplace, a staircase, and a chandelier.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

1. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Casey
￥28,918
￥33,565 total
includes taxes & fees
Sep 29 - Sep 30
DuPont Mansion Bed & Breakfast
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.
A bar with shelves of liquor bottles and a bartender preparing drinks.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

2. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Adam
￥38,976
￥45,858 total
includes taxes & fees
Oct 11 - Oct 12
Hotel Distil, Autograph Collection
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

3. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Meghan
￥22,435
￥26,398 total
includes taxes & fees
Sep 28 - Sep 29
The Brown Hotel
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A lobby with a marble floor, a reception desk, and a large chandelier.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A modern interior with a fireplace, bookshelves, and seating areas.

4. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Travis
￥44,189
￥51,992 total
includes taxes & fees
Oct 14 - Oct 15
Omni Louisville Hotel
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.
A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

5. Stellar Suites

Stellar Suites
East Market District, 2.2 km from 21c Museum Hotel
United States
Benton
￥15,562
￥26,329 total
includes taxes & fees
Oct 18 - Oct 19
Stellar Suites
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.
A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.
A swimming pool with lounge chairs and a view of the city.

6. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Steve
￥19,552
￥23,005 total
includes taxes & fees
Oct 25 - Oct 26
Homewood Suites by Hilton Louisville Downtown, KY
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A building with a sign reading "THE GRADY" at the entrance.

7. The Grady

The Grady
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Bruce
￥27,742
￥32,642 total
includes taxes & fees
Oct 11 - Oct 12
The Grady
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.
A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

8. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 2 km from 21c Museum Hotel
United States
Addison
￥19,396
￥22,822 total
includes taxes & fees
Oct 4 - Oct 5
Tempo By Hilton Louisville Downtown Nulu
A modern bar area with a circular bar, multiple seating options, and a large screen.
A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.
A modern lobby with a fireplace, seating area, and a reception desk.

9. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Cinda
￥15,418
￥18,140 total
includes taxes & fees
Oct 25 - Oct 26
Cambria Hotel Louisville Downtown-Whiskey Row
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A steam fountain in a brick alleyway.

10. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 km from 21c Museum Hotel
United States
Matt
￥25,505
￥30,804 total
includes taxes & fees
Oct 26 - Oct 27
21c Museum Hotel Louisville
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Cameron
￥33,715
￥39,668 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A modern living room with a sofa, ottomans, a coffee table, and a rug.
A cozy living room with a fireplace, a black leather sofa, and a patterned rug.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

12. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Bryan
￥20,320
￥23,908 total
includes taxes & fees
Oct 11 - Oct 12
Moxy Louisville Downtown
An outdoor seating area with wicker furniture and a fire pit.
A modern living room with a sofa, armchairs, a coffee table, and a TV.
A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.
An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

13. Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
Downtown Louisville, 0.3 km from 21c Museum Hotel
United States
Scott
￥17,463
￥20,547 total
includes taxes & fees
Oct 25 - Oct 26
Towneplace Suites By Marriott Louisville Downtown
An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.
A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.
A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.
A modern bar area with sofas, tables, and a bar stocked with bottles.

14. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Angela
￥21,052
￥24,770 total
includes taxes & fees
Oct 4 - Oct 5
Aloft by Marriott Louisville Downtown
A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.
A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.
A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.
A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

15. AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
East Market District, 2 km from 21c Museum Hotel
United States
Jen
￥22,717
￥26,729 total
includes taxes & fees
Oct 4 - Oct 5
AC Hotel Louisville Downtown
A covered patio with a stone wall, a glass table, and a bench.
A stone house with a balcony, a front door, and a staircase leading to the entrance.
A garden pathway with a lantern, potted plants, and a white fence.

16. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 2.9 km from 21c Museum Hotel
United States
Brittany
￥25,137
￥29,177 total
includes taxes & fees
Oct 5 - Oct 6
Central Park Bed & Breakfast
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

17. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from 21c Museum Hotel
United States
Saud
￥23,876
￥28,092 total
includes taxes & fees
Oct 25 - Oct 26
Galt House Hotel Trademark Collection by Wyndham
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.
A reception area with marble counters, modern pendant lighting, and potted orchids.
A modern bar area with glass partitions, bar stools, and a variety of bottles.

18. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville, 0.7 km from 21c Museum Hotel
United States
Jacobi
￥33,995
￥39,999 total
includes taxes & fees
Oct 12 - Oct 13
Louisville Marriott Downtown
A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.
A grand lobby with marble floors, a staircase, and a reception desk.
A spacious living room with a fireplace, wooden paneling, a television, and a blue sofa.
A bakery display with pastries and bread, a coffee station, and a Christmas tree in the background.

19. Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
DAVID
￥30,524
￥35,916 total
includes taxes & fees
Oct 4 - Oct 5
Seelbach Hilton Louisville Downtown
A hotel room with two beds, a wooden headboard, bedside lamps, a small table, and a patterned rug.
A modern interior with a curved wall featuring vertical lines and geometric patterns.
A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG
Downtown Louisville, 0.3 km from 21c Museum Hotel
United States
Carlos
￥15,716
￥18,491 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Louisville Downtown by IHG
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Compare popular hotels close to 21c Museum Hotel

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
147 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
506 reviews
View
A grand lobby with ornate columns, plush seating, and a chandelier.
The Brown Hotel
9.4
Exceptional
1,325 reviews
View
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
Omni Louisville Hotel
9.4
Exceptional
2,154 reviews
View
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
Stellar Suites
9.4
Exceptional
152 reviews
View

Top 21c Museum Hotel Hotel Reviews

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent
"Pleasantly surprised how nice this hotel was. Rooms were very clean and comfortable. Front desk was always pleasant and helpful! Would definitely stay there again and walking distance to so many great things to do, eat and drink!"
Sharon 4-night trip
Posted less than an hour ago
Homewood Suites by Hilton Louisville Downtown, KY
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

8/10 Good
"Only stayed one night, everything was fine. Thought the room would be a bit nicer. Friendly staff!"
Nancy 1-night trip
Posted 1 hour ago
Galt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel

Omni Louisville Hotel

10/10 Excellent
"Everything we needed was on-site. The Falls Market restaurant and store were very helpful for food and other things we needed. Valet staff was friendly and helpful. Only complaints- hot tub was broken and neither front desk or guest services answered the phone the couple of times I tried to call."
Stephanie 3-night trip
Posted 2 hours ago
Omni Louisville Hotel
The Brown Hotel

The Brown Hotel

10/10 Excellent
"Beautiful old hotel."
Debi 2-night trip
Posted 6 hours ago
The Brown Hotel
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

10/10 Excellent
"Great stay for LTL and visiting restaurants."
Antonio 1-night trip
Posted 14 hours ago
Embassy Suites Louisville Downtown
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent
"Walking to Louisville Slugger and Muhammad Ali museum .Safe area to walk. Nice restaurants. Nice breakfast"
Kathleen 2-night trip
Posted 23 hours ago
Holiday Inn Express & Suites Louisville Downtown by IHG
Hyatt Regency Louisville

Hyatt Regency Louisville

10/10 Excellent
"Clean rooms, good room service, amazing on site restaraunt and bar. In door pool is kinda small but clean"
Pavel 1-night trip
Posted 2 days ago
Hyatt Regency Louisville
The Grady

The Grady

10/10 Excellent
"Nice place. Fantastic location. Next to major distilleries and bars."
Joerg 1-night trip
Posted 2 days ago
The Grady
Moxy Louisville Downtown

Moxy Louisville Downtown

8/10 Good
"No way to get hot water for tea for guests."
David 1-night trip
Posted 3 days ago
Moxy Louisville Downtown

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A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)
Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
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The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.
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Evan Williams Bourbon Experience

8.6/10 (20 reviews)
You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
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Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.
What's the best place to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.
How many hotels will I find close to 21c Museum Hotel?
Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.
Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?
For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center, or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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