The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A covered outdoor seating area with wicker furniture and a wooden railing.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥44,176

￥51,275 total

includes taxes & fees

Oct 19 - Oct 20

A wooden staircase with a balustrade leading to a landing.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A brick building with a covered porch, columns, and potted plants.

A two-story brick building with a white porch and a sign reading "Hotel".

2. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

￥31,033

￥35,067 total

includes taxes & fees

Oct 26 - Oct 27

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥22,658

￥26,300 total

includes taxes & fees

Nov 4 - Nov 5

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

4. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

￥37,553

￥44,185 total

includes taxes & fees

Oct 29 - Oct 30

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

5. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

John

￥19,841

￥23,345 total

includes taxes & fees

Oct 29 - Oct 30

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

6. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Gordon

￥16,122

￥18,970 total

includes taxes & fees

Oct 25 - Oct 26

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

7. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Kelly

￥18,975

￥22,326 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A lobby with a marble floor, a reception desk, and a large chandelier.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A modern interior with a fireplace, bookshelves, and seating areas.

8. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Samantha

￥33,157

￥39,012 total

includes taxes & fees

Oct 18 - Oct 19

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A building with a sign reading "THE GRADY" at the entrance.

9. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

￥25,854

￥30,419 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

10. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥18,311

￥29,523 total

includes taxes & fees

Oct 18 - Oct 19

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

11. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥24,135

￥29,190 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

12. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥19,346

￥22,763 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor seating area with wicker furniture and a fire pit.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

A modern lounge area with seating, tables, and a view of the city through large windows.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

13. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Derek

￥15,388

￥18,105 total

includes taxes & fees

Nov 8 - Nov 9

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A modern hotel room with a large bed, a city view, and a unique headboard design.

14. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Cameron

￥28,435

￥33,456 total

includes taxes & fees

Oct 25 - Oct 26

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

15. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

￥18,906

￥22,245 total

includes taxes & fees

Oct 28 - Oct 29

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

16. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Dolores

￥21,499

￥25,296 total

includes taxes & fees

Nov 8 - Nov 9

A covered patio with a stone wall, a glass table, and a bench.

A grand room with a fireplace, a staircase, and a chandelier.

A garden pathway with a lantern, potted plants, and a white fence.

17. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

￥24,066

￥27,934 total

includes taxes & fees

Oct 25 - Oct 26

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A brightly lit grocery store with yellow shelving and a central checkout counter.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

18. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

￥22,844

￥26,879 total

includes taxes & fees

Oct 26 - Oct 27

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

19. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,658

￥26,659 total

includes taxes & fees

Oct 25 - Oct 26

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Mark

￥22,917

￥26,965 total

includes taxes & fees

Oct 29 - Oct 30

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 125 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 149 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 510 reviews	View
The Brown Hotel	9.4 Exceptional 1,378 reviews	View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Amazing property, clean, close to downtown, excellent staff. Will highly recommend."

21c Museum Hotel Louisville

10/10 Excellent

"This was our second stay here and will stay again when in town. Very cool place if you like art. Great service. Nice room but nothing really special about it. Super convenient location downtown on Main Street, walking distance to many attractions and distilleries. Very good on-site restaurant/bar."

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"The staff were very helpful & great location."

Louisville Marriott Downtown

8/10 Good

"room was very clean but the there were additional blankets provided"

Embassy Suites Louisville Downtown

10/10 Excellent

"The hotel is amazing! Great spa e, high ceilings, breakfast was great and filling. The room was so nice that I dreaded leaving the room. The staff was kind and courteous. I will be back just for the experience. Its near all sorts of entertainment."

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"Very comfortable place to stay and all the team was very nice!"

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent

"Great location- super responsive host - clean and great view of the river."

The PRES@The 713! Penthouse Suite with private rooftop patio, on Bourbon Trail!

10/10 Excellent

"Wonderful experience from making the reservation until the end of our stay. Great communication with the hosts. And enjoyed the location and the loft was very comfortable."

Bluegrass River View! Soak & Savor by Hollyhock

10/10 Excellent

"Thank you for hosting us. Our boys basketball team used this as home base with 2 dad's and 4 kids staying here. Everyone had a blast and enjoyed the view."

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. DuPont Mansion Bed & Breakfast

4. Hotel Distil, Autograph Collection

5. The Brown Hotel

6. Cambria Hotel Louisville Downtown-Whiskey Row

7. Homewood Suites by Hilton Louisville Downtown, KY

8. Omni Louisville Hotel

9. The Grady

10. Stellar Suites

11. 21c Museum Hotel Louisville

12. Tempo By Hilton Louisville Downtown Nulu

13. Towneplace Suites By Marriott Louisville Downtown

14. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

15. Moxy Louisville Downtown

16. Aloft by Marriott Louisville Downtown

17. Central Park Bed & Breakfast

18. Hotel Genevieve part of JdV by Hyatt

19. AC Hotel Louisville Downtown

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

21c Museum Hotel Louisville

Cambria Hotel Louisville Downtown-Whiskey Row

Louisville Marriott Downtown

Embassy Suites Louisville Downtown

Homewood Suites by Hilton Louisville Downtown, KY

Suite 7 City Loft Escape with River Views! By Hollyhock

The PRES@The 713! Penthouse Suite with private rooftop patio, on Bourbon Trail!

Bluegrass River View! Soak & Savor by Hollyhock

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

Explore a world of travel with Expedia