The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A covered outdoor seating area with wicker furniture and a wooden railing.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥43,767

￥50,802 total

includes taxes & fees

Oct 27 - Oct 28

A wooden staircase with a balustrade leading to a landing.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

A two-story brick building with a white porch and a sign reading "Hotel".

A dining area with brick walls, wooden shelves, and tables set for a meal.

2. Market Street Inn

2.1 km from 21c Museum Hotel

"Such a lovely stay at the Market Street Inn. A very charming, comfortable and feels like home kind of place. Carol and Steve are just the kindest owners. They were responsive and accommodating and always available if needed. We also loved meeting Lisa, who made breakfast each morning and took care of any housekeeping needs. We felt like we were treated as family and not just guests. The area and location is perfect, SUCH a cute little town. Plenty of restaurants, shops and entertainment within...

Ryan

￥34,689

￥39,199 total

includes taxes & fees

Oct 27 - Oct 28

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A bar with shelves of liquor bottles and a bartender preparing drinks.

3. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

￥31,612

￥37,195 total

includes taxes & fees

Nov 22 - Nov 23

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

4. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥26,575

￥30,845 total

includes taxes & fees

Nov 26 - Nov 27

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

5. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

katisha

￥20,361

￥23,958 total

includes taxes & fees

Nov 25 - Nov 26

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A swimming pool with lounge chairs and a view of the city.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

peter

￥17,880

￥21,037 total

includes taxes & fees

Nov 24 - Nov 25

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern interior with a fireplace, bookshelves, and seating areas.

A lobby with a marble floor, a reception desk, and a large chandelier.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

7. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Kristan

￥31,876

￥37,505 total

includes taxes & fees

Nov 16 - Nov 17

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

8. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥23,866

￥28,865 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Adrienne Tremonti

￥20,453

￥24,064 total

includes taxes & fees

Nov 23 - Nov 24

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

10. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥15,951

￥18,768 total

includes taxes & fees

Nov 25 - Nov 26

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A building with a sign reading "THE GRADY" at the entrance.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

11. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

￥23,361

￥27,487 total

includes taxes & fees

Nov 26 - Nov 27

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

12. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥15,890

￥26,638 total

includes taxes & fees

Oct 27 - Oct 28

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern lobby with a fireplace, seating area, and a reception desk.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

13. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Sarah

￥14,934

￥17,572 total

includes taxes & fees

Nov 22 - Nov 23

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

14. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

￥18,534

￥21,806 total

includes taxes & fees

Nov 15 - Nov 16

A brick building with outdoor seating and a fire pit.

An indoor swimming pool with clear water, surrounded by blue chairs and tables, and a tiled floor.

A modern restaurant with wooden furniture, a central island, and a high ceiling.

A modern bar area with a wooden counter, bar stools, and a variety of bottles and glasses.

15. TownePlace Suites by Marriott Louisville North

2.2 km from 21c Museum Hotel

Lori M

￥18,981

￥21,449 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor dining area with a long table and wicker chairs, overhead lighting, and a view of the city.

A spacious lounge area with arched windows, comfortable seating, and a variety of plants.

A hotel lobby with a wooden reception desk, a seating area with a sofa, and a large window with potted plants.

16. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

￥21,177

￥24,917 total

includes taxes & fees

Nov 15 - Nov 16

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

17. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Anthony

￥19,188

￥22,577 total

includes taxes & fees

Nov 23 - Nov 24

A covered patio with a stone wall, a glass table, and a bench.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A grand room with a fireplace, a staircase, and a chandelier.

18. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

￥25,182

￥29,228 total

includes taxes & fees

Nov 11 - Nov 12

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

19. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,448

￥26,412 total

includes taxes & fees

Nov 6 - Nov 7

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A balcony with a view of a river, a bridge, and a cityscape.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Shun

￥21,353

￥25,124 total

includes taxes & fees

Nov 8 - Nov 9

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 127 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 512 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 150 reviews	View
The Brown Hotel	9.4 Exceptional 1,430 reviews	View

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

10/10 Excellent

"Clean & cozy!"

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"The staff was wonderful. Unfortunately, I had to change rooms because of my error. But the staff was so accommodating. They didn’t make me feel like I was making it an inconvenience. The breakfast was wonderful. I Always greeted with the smile. Very good for being a downtown location."

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"The two bedroom suite was amazing. So much room which is great for a family of 5. Beautiful view of the river. Unfortunately no indoor pool."

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good

"Staff were very nice . No complaints"

The Grady

10/10 Excellent

"Great experience staying at the Grady. Clean. Charm. Convenience."

21c Museum Hotel Louisville

10/10 Excellent

"Upscale, interesting hotel in a great location in downtown Louisville. Quiet, with a comfortable bed and large bathroom. Large bottles of drinking water provided at no extra charge in the room. Staff was super helpful in recommending a nearby cafe for espresso and pastries in the morning. Valet parking was $35 - but that's typical for downtown hotels."

Homewood Suites by Hilton Louisville Downtown, KY

8/10 Good

"Night room , affordable price.staff really nice"

Embassy Suites Louisville Downtown

10/10 Excellent

"Great breakfast...made to order omelets."

Hyatt Regency Louisville

10/10 Excellent

"Great hotel"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

See properties

A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Find hotels near 21c Museum Hotel, Louisville from ￥17,572

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Treat yourself

Be picky

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. Hotel Distil, Autograph Collection

4. DuPont Mansion Bed & Breakfast

5. The Brown Hotel

6. Homewood Suites by Hilton Louisville Downtown, KY

7. Omni Louisville Hotel

8. 21c Museum Hotel Louisville

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

10. Tempo By Hilton Louisville Downtown Nulu

11. The Grady

12. Stellar Suites

13. Cambria Hotel Louisville Downtown-Whiskey Row

14. Moxy Louisville Downtown

15. TownePlace Suites by Marriott Louisville North

16. Hotel Genevieve part of JdV by Hyatt

17. Aloft by Marriott Louisville Downtown

18. Central Park Bed & Breakfast

19. AC Hotel Louisville Downtown

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

Towneplace Suites By Marriott Louisville Downtown

Galt House Hotel Trademark Collection by Wyndham

Holiday Inn Express & Suites Louisville Downtown by IHG

The Grady

21c Museum Hotel Louisville

Homewood Suites by Hilton Louisville Downtown, KY

Embassy Suites Louisville Downtown

Hyatt Regency Louisville

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

Explore a world of travel with Expedia