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Oct 21 - Oct 22
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Oct 22 - Oct 23
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Oct 23 - Oct 25
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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.
A living room with a sofa, armchair, coffee table, fireplace, and large windows.
A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Roy
￥44,160
￥51,256 total
includes taxes & fees
Oct 25 - Oct 26
Louisville Bourbon Inn
A wooden staircase with a balustrade leading to a landing.
A bedroom with a bed, a dresser, a television, and a desk with a lamp.
A two-story brick building with a white porch and a sign reading "Hotel".
A brick building with a covered porch, columns, and potted plants.

2. Market Street Inn

Market Street Inn
2.1 km from 21c Museum Hotel
United States
Holly
￥35,000
￥39,551 total
includes taxes & fees
Oct 25 - Oct 26
Market Street Inn
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.
A room with a red velvet sofa, a blue armchair, and a small round table with books.
An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

3. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Casey
￥25,949
￥30,119 total
includes taxes & fees
Nov 19 - Nov 20
DuPont Mansion Bed & Breakfast
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

4. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Heather
￥36,075
￥42,444 total
includes taxes & fees
Nov 8 - Nov 9
Hotel Distil, Autograph Collection
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.
A swimming pool with lounge chairs and a view of the city.
A spacious lobby with a large seating area, a chandelier, and a patterned rug.

5. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
peter
￥18,305
￥21,537 total
includes taxes & fees
Nov 11 - Nov 12
Homewood Suites by Hilton Louisville Downtown, KY
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

6. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
John
￥22,666
￥26,669 total
includes taxes & fees
Oct 25 - Oct 26
The Brown Hotel
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A modern interior with a fireplace, bookshelves, and seating areas.

7. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Kristan
￥32,162
￥37,843 total
includes taxes & fees
Nov 16 - Nov 17
Omni Louisville Hotel
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A modern restaurant interior with a staircase, round tables, and a brick wall.
A building with a sign reading "THE GRADY" at the entrance.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

8. The Grady

The Grady
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Donna
￥24,651
￥29,004 total
includes taxes & fees
Nov 15 - Nov 16
The Grady
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".
A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

9. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 2 km from 21c Museum Hotel
United States
Addison
￥18,690
￥21,990 total
includes taxes & fees
Oct 29 - Oct 30
Tempo By Hilton Louisville Downtown Nulu
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A steam fountain in a brick alleyway.

10. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 km from 21c Museum Hotel
United States
Matt
￥24,081
￥29,125 total
includes taxes & fees
Nov 15 - Nov 16
21c Museum Hotel Louisville
A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Cameron
￥23,232
￥27,335 total
includes taxes & fees
Nov 9 - Nov 10
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
An outdoor seating area with wicker furniture and a fire pit.
An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.
A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.
A modern lounge area with seating, tables, and a view of the city through large windows.

12. Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
Downtown Louisville, 0.3 km from 21c Museum Hotel
United States
Barbara
￥15,353
￥18,065 total
includes taxes & fees
Nov 8 - Nov 9
Towneplace Suites By Marriott Louisville Downtown
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.
A modern lobby with a fireplace, seating area, and a reception desk.
A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.
A modern bar area with a circular bar, multiple seating options, and a large screen.

13. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Sarah
￥16,334
￥19,220 total
includes taxes & fees
Nov 15 - Nov 16
Cambria Hotel Louisville Downtown-Whiskey Row
A covered patio with a stone wall, a glass table, and a bench.
Staircase
A grand room with a fireplace, a staircase, and a chandelier.
A stone house with a balcony, a front door, and a staircase leading to the entrance.

14. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 2.9 km from 21c Museum Hotel
United States
Nicole
￥24,598
￥28,551 total
includes taxes & fees
Oct 25 - Oct 26
Central Park Bed & Breakfast
A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.
A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.
A modern coffee shop interior with a central island, wooden counter, and large windows.
A modern bar area with sofas, tables, and a bar stocked with bottles.

15. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Anthony
￥20,755
￥24,420 total
includes taxes & fees
Nov 15 - Nov 16
Aloft by Marriott Louisville Downtown
A cozy living room with a fireplace, a black leather sofa, and a patterned rug.
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A modern living room with a sofa, ottomans, a coffee table, and a rug.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

16. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Alicia
￥18,701
￥22,004 total
includes taxes & fees
Nov 15 - Nov 16
Moxy Louisville Downtown
A bedroom with a bed, a chair, a TV, and a window with curtains.
A brightly lit grocery store with yellow shelving and a central checkout counter.
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

17. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 2 km from 21c Museum Hotel
United States
Tyler
￥21,368
￥25,141 total
includes taxes & fees
Oct 30 - Oct 31
Hotel Genevieve part of JdV by Hyatt
A balcony with a view of a river, a bridge, and a cityscape.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

18. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from 21c Museum Hotel
United States
Judy
￥22,192
￥26,111 total
includes taxes & fees
Nov 8 - Nov 9
Galt House Hotel Trademark Collection by Wyndham
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.
An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.
A hotel dining area with long tables, booths, and a bar.
A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

19. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Frances
￥20,637
￥24,281 total
includes taxes & fees
Nov 15 - Nov 16
Embassy Suites Louisville Downtown
A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A reception area with marble counters, modern pendant lighting, and potted orchids.
A modern bar area with glass partitions, bar stools, and a variety of bottles.

20. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville, 0.7 km from 21c Museum Hotel
United States
Ricardo
￥31,172
￥36,676 total
includes taxes & fees
Nov 8 - Nov 9
Louisville Marriott Downtown
View all properties

Compare popular hotels close to 21c Museum Hotel

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
Louisville Bourbon Inn
10.0
Exceptional
25 reviews
View
A wooden staircase with a balustrade leading to a landing.
Market Street Inn
9.8
Exceptional
125 reviews
View
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
150 reviews
View
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.
Hotel Distil, Autograph Collection
9.6
Exceptional
511 reviews
View
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
Homewood Suites by Hilton Louisville Downtown, KY
9.4
Exceptional
1,000 reviews
View

Top 21c Museum Hotel Hotel Reviews

Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent
"The room was so clean it made the stay very relaxing."
Gavin 1-night trip
Posted less than an hour ago
Holiday Inn Express & Suites Louisville Downtown by IHG
Hyatt Regency Louisville

Hyatt Regency Louisville

10/10 Excellent
"Everything was great. I was only confused as to why the room didn't have a microwave."
Ebony 1-night trip
Posted 8 hours ago
Hyatt Regency Louisville
21c Museum Hotel Louisville

21c Museum Hotel Louisville

10/10 Excellent
"If you love ORIGINALITY this is the place!!! We absolutely loved our stay …. funky, innovative and simply refreshing. The inspiring art is an absolute treat. Great taste and finally not another copycat hotel. AND the service was excellent, bed super comfortable, lovely bathroom and we couldn’t have been happier. If you haven’t tried it. It’s an absolute must!!!"
Petra 1-night trip
Posted 18 hours ago
21c Museum Hotel Louisville
Holiday Inn Louisville Downtown by IHG

Holiday Inn Louisville Downtown by IHG

10/10 Excellent
"Very clean, modern facility for a quick overnight. I did not use many of the amenities due to the shortness of my stay. Staff was very friendly and helpful."
Edward 1-night trip
Posted 22 hours ago
Holiday Inn Louisville Downtown by IHG
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent
"A five star hotel with a three star budget. This place was wonderful in all ways. So thankful to have found them"
Mark 3-night trip
Posted 1 day ago
Homewood Suites by Hilton Louisville Downtown, KY
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent
"déjeuner hors pair en plus de l'endroit propre et agréable"
Denise 2-night trip
Posted 1 day ago
Towneplace Suites By Marriott Louisville Downtown
The Grady

The Grady

10/10 Excellent
"Lovely boutique hotel. Great location, very nice staff. Only issue was trying to get into on-site restaurant which was always booked up."
Nancy 4-night trip
Posted 2 days ago
The Grady
Suite 7 City Loft Escape with River Views! By Hollyhock

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent
"Great location- super responsive host - clean and great view of the river."
Jim M. 3-night trip
Posted 3 weeks ago
Suite 7 City Loft Escape with River Views! By Hollyhock
Main Street Farmhouse. City Retreat by Hollyhock

Main Street Farmhouse. City Retreat by Hollyhock

10/10 Excellent
"Great location for walking Whiskey Row"
Steve M. 3-night trip
Posted 2 months ago
Main Street Farmhouse. City Retreat by Hollyhock

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)
Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
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The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.
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Evan Williams Bourbon Experience

8.6/10 (20 reviews)
You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
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Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.
What's the best place to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.
How many hotels will I find close to 21c Museum Hotel?
Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.
Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?
For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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