The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥43,770

￥50,805 total

includes taxes & fees

Oct 5 - Oct 6

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, large windows, and classic furniture.

2. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Melanie

￥22,237

￥26,164 total

includes taxes & fees

Sep 28 - Sep 29

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥28,577

￥33,169 total

includes taxes & fees

Oct 5 - Oct 6

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

4. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Cinda

￥18,700

￥22,003 total

includes taxes & fees

Oct 18 - Oct 19

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

5. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Diane

￥22,512

￥26,487 total

includes taxes & fees

Oct 5 - Oct 6

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

6. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Maria

￥23,670

￥27,850 total

includes taxes & fees

Oct 5 - Oct 6

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

7. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Adam

￥38,623

￥45,445 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A modern restaurant interior with a staircase, round tables, and a brick wall.

A building with a sign reading "THE GRADY" at the entrance.

8. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Bruce

￥27,415

￥32,257 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

9. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Benton

￥15,425

￥26,098 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Breeana

￥33,318

￥39,202 total

includes taxes & fees

Sep 28 - Sep 29

An outdoor seating area with wicker furniture and a fire pit.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

A modern lounge area with seating, tables, and a view of the city through large windows.

A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.

11. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Scott

￥19,139

￥22,519 total

includes taxes & fees

Oct 11 - Oct 12

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A bedroom with a bed, a chair, a TV, and a window with curtains.

12. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Rebekah

￥23,911

￥28,133 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A balcony with a view of a river, a bridge, and a cityscape.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

13. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Saud

￥25,480

￥29,980 total

includes taxes & fees

Oct 5 - Oct 6

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

14. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,511

￥26,487 total

includes taxes & fees

Oct 4 - Oct 5

A covered patio with a stone wall, a glass table, and a bench.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A grand room with a fireplace, a staircase, and a chandelier.

15. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Angie

￥24,648

￥28,609 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

A hotel dining area with long tables, booths, and a bar.

A modern hotel room with a living area, a dining area, and a bedroom.

16. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Maurica

￥25,670

￥30,204 total

includes taxes & fees

Oct 11 - Oct 12

A modern lobby with a curved seating area, a red ottoman, and a television screen.

A modern interior with a curved wall featuring vertical lines and geometric patterns.

A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.

17. Holiday Inn Express & Suites Louisville Downtown by IHG

Downtown Louisville, 0.3 km from 21c Museum Hotel

Carlos

￥18,563

￥21,842 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a central escalator, comfortable seating areas, and modern lighting fixtures.

An outdoor seating area with wicker furniture, wooden tables, and large lamps.

A modern lobby with a central seating area, an escalator, and a staircase.

A modern hotel exterior with outdoor seating, a glass canopy, and a visible sign for the Hyatt Regency.

18. Hyatt Regency Louisville

Downtown Louisville, 0.6 km from 21c Museum Hotel

Sandra

￥28,001

￥32,946 total

includes taxes & fees

Oct 15 - Oct 16

A modern kitchen with wooden cabinets, a long countertop, and a variety of food items displayed.

A hotel room with two beds, a TV, and a desk.

An outdoor patio area with a wooden pergola, tables, chairs, and potted plants.

A multi-story hotel with a prominent signage for SpringHill Suites Marriott.

19. SpringHill Suites by Marriott Louisville Downtown

Downtown Louisville, 1 km from 21c Museum Hotel

Beau

￥18,586

￥21,867 total

includes taxes & fees

Oct 12 - Oct 13

A Courtyard by Marriott hotel with a modern brick facade, multiple floors, and a prominent sign.

A modern hotel lobby with a large seating area, a flat-screen TV, and a large window with sheer curtains.

A modern living room with a fireplace, comfortable seating, and a large TV.

An outdoor patio area with wicker furniture, including sofas and a coffee table, surrounded by a black metal fence.

20. Courtyard by Marriott Louisville Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

sabrina

￥21,612

￥25,429 total

includes taxes & fees

Oct 1 - Oct 2

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
The Brown Hotel	9.4 Exceptional 1,310 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 147 reviews	View
Cambria Hotel Louisville Downtown-Whiskey Row	9.4 Exceptional 1,008 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	9.4 Exceptional 1,009 reviews	View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

8/10 Good

"It was good. Staff seemed a little overwhelmed when we arrived for an almost 1 a.m. check-in. It was very busy the night before Louder Than Life. The breakfast restaurant wasn't busy and was still slow. The food was great, but we didn't go back since we had a schedule to keep."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"Super easy to walk to a bunch of distilleries and also get to great restaurants and speakeasies."

The Brown Hotel

10/10 Excellent

"Beautifully restored historic hotel. It reminded us of the Palmer House in Chicago."

Hyatt Regency Louisville

8/10 Good

"Was close to all activities walking distance"

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"We drink tea, it was not available in the room, nor at the dinner on second floor. Bummer! Everything else was well planned to accommodate most."

Embassy Suites Louisville Downtown

10/10 Excellent

"The breakfast service was exceptional. The property is ideally situated, with a wide array of dining options and entertainment venues within convenient walking distance."

The Grady

10/10 Excellent

"Great property in the heart of downtown Louisville. Our room was well-appointed and service was great."

Louisville Marriott Downtown

10/10 Excellent

"It was completely comfortable"

21c Museum Hotel Louisville

10/10 Excellent

"It was a great stay! The room and location were perfect, and the staff were very accommodating!"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. The Brown Hotel

3. DuPont Mansion Bed & Breakfast

4. Cambria Hotel Louisville Downtown-Whiskey Row

5. Homewood Suites by Hilton Louisville Downtown, KY

6. Tempo By Hilton Louisville Downtown Nulu

7. Hotel Distil, Autograph Collection

8. The Grady

9. Stellar Suites

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

11. Towneplace Suites By Marriott Louisville Downtown

12. Hotel Genevieve part of JdV by Hyatt

13. Galt House Hotel Trademark Collection by Wyndham

14. AC Hotel Louisville Downtown

15. Central Park Bed & Breakfast

16. Embassy Suites Louisville Downtown

17. Holiday Inn Express & Suites Louisville Downtown by IHG

18. Hyatt Regency Louisville

19. SpringHill Suites by Marriott Louisville Downtown

20. Courtyard by Marriott Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Aloft by Marriott Louisville Downtown

The Brown Hotel

Hyatt Regency Louisville

Cambria Hotel Louisville Downtown-Whiskey Row

Embassy Suites Louisville Downtown

The Grady

Louisville Marriott Downtown

21c Museum Hotel Louisville

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

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