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Sep 24 - Sep 25
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Sep 25 - Sep 26
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Sep 25 - Sep 27
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Our top choices for 21c Museum Hotel hotels

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.
A room with a red velvet sofa, a blue armchair, and a small round table with books.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

1. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Casey
￥28,681
￥33,290 total
includes taxes & fees
Oct 5 - Oct 6
DuPont Mansion Bed & Breakfast
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.
A bar with shelves of liquor bottles and a bartender preparing drinks.

2. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Adam
￥38,858
￥45,721 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Distil, Autograph Collection
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

3. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Melanie
￥22,318
￥26,260 total
includes taxes & fees
Sep 28 - Sep 29
The Brown Hotel
A modern bar area with a circular bar, multiple seating options, and a large screen.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.
A modern lobby with a fireplace, seating area, and a reception desk.
A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

4. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Cinda
￥15,371
￥18,086 total
includes taxes & fees
Oct 25 - Oct 26
Cambria Hotel Louisville Downtown-Whiskey Row
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.
A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

5. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 2 km from 21c Museum Hotel
United States
Maria
￥19,337
￥22,753 total
includes taxes & fees
Oct 4 - Oct 5
Tempo By Hilton Louisville Downtown Nulu
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A spacious lobby with a large seating area, a chandelier, and a patterned rug.
A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.
A swimming pool with lounge chairs and a view of the city.

6. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Diane
￥19,238
￥22,635 total
includes taxes & fees
Oct 25 - Oct 26
Homewood Suites by Hilton Louisville Downtown, KY
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A steam fountain in a brick alleyway.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

7. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 km from 21c Museum Hotel
United States
Matt
￥28,117
￥33,873 total
includes taxes & fees
Oct 25 - Oct 26
21c Museum Hotel Louisville
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.
A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

8. Stellar Suites

Stellar Suites
East Market District, 2.2 km from 21c Museum Hotel
United States
Benton
￥15,482
￥26,194 total
includes taxes & fees
Oct 18 - Oct 19
Stellar Suites
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A modern restaurant interior with a staircase, round tables, and a brick wall.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.
A building with a sign reading "THE GRADY" at the entrance.

9. The Grady

The Grady
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Bruce
￥27,657
￥32,542 total
includes taxes & fees
Oct 11 - Oct 12
The Grady
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.
A modern interior with a fireplace, bookshelves, and seating areas.
A lobby with a marble floor, a reception desk, and a large chandelier.

10. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Gilbert
￥43,960
￥51,725 total
includes taxes & fees
Oct 13 - Oct 14
Omni Louisville Hotel
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.
A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Cameron
￥33,439
￥39,344 total
includes taxes & fees
Oct 12 - Oct 13
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
An outdoor seating area with wicker furniture and a fire pit.
An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.
A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.
A modern living room with a sofa, armchairs, a coffee table, and a TV.

12. Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
Downtown Louisville, 0.3 km from 21c Museum Hotel
United States
Scott
￥17,410
￥20,484 total
includes taxes & fees
Oct 25 - Oct 26
Towneplace Suites By Marriott Louisville Downtown
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A modern living room with a sofa, ottomans, a coffee table, and a rug.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.
A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

13. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Bryan
￥20,259
￥23,835 total
includes taxes & fees
Oct 11 - Oct 12
Moxy Louisville Downtown
An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.
A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.
A modern bar area with sofas, tables, and a bar stocked with bottles.
A modern coffee shop interior with a central island, wooden counter, and large windows.

14. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.9 km from 21c Museum Hotel
United States
Angela
￥20,754
￥24,419 total
includes taxes & fees
Oct 4 - Oct 5
Aloft by Marriott Louisville Downtown
A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.
A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.
A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.
A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

15. AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
East Market District, 2 km from 21c Museum Hotel
United States
Jen
￥22,648
￥26,647 total
includes taxes & fees
Oct 4 - Oct 5
AC Hotel Louisville Downtown
A covered patio with a stone wall, a glass table, and a bench.
A stone house with a balcony, a front door, and a staircase leading to the entrance.
A grand room with a fireplace, a staircase, and a chandelier.

16. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 2.9 km from 21c Museum Hotel
United States
Angie
￥25,137
￥29,177 total
includes taxes & fees
Oct 19 - Oct 20
Central Park Bed & Breakfast
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A brightly lit grocery store with yellow shelving and a central checkout counter.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.
A bedroom with a bed, a chair, a TV, and a window with curtains.

17. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 2 km from 21c Museum Hotel
United States
Rebekah
￥24,057
￥28,306 total
includes taxes & fees
Oct 4 - Oct 5
Hotel Genevieve part of JdV by Hyatt
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A balcony with a view of a river, a bridge, and a cityscape.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

18. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from 21c Museum Hotel
United States
Saud
￥23,804
￥28,008 total
includes taxes & fees
Oct 25 - Oct 26
Galt House Hotel Trademark Collection by Wyndham
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A modern bar area with glass partitions, bar stools, and a variety of bottles.
A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.
A reception area with marble counters, modern pendant lighting, and potted orchids.

19. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville, 0.7 km from 21c Museum Hotel
United States
Jacobi
￥33,716
￥39,670 total
includes taxes & fees
Oct 12 - Oct 13
Louisville Marriott Downtown
A modern lobby with a curved seating area, a red ottoman, and a television screen.
A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.
A modern interior with a curved wall featuring vertical lines and geometric patterns.

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG
Downtown Louisville, 0.3 km from 21c Museum Hotel
United States
Carlos
￥15,669
￥18,437 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Louisville Downtown by IHG
View all properties

Compare popular hotels close to 21c Museum Hotel

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
147 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
505 reviews
View
A grand lobby with ornate columns, plush seating, and a chandelier.
The Brown Hotel
9.4
Exceptional
1,321 reviews
View
A modern bar area with a circular bar, multiple seating options, and a large screen.
Cambria Hotel Louisville Downtown-Whiskey Row
9.4
Exceptional
1,010 reviews
View
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
Tempo By Hilton Louisville Downtown Nulu
9.4
Exceptional
1,123 reviews
View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"Great rooms, a number of great restaurants and bars, great staff. I will come back next time I am in Louisville."
Charles 3-night trip
Posted 9 hours ago
Galt House Hotel Trademark Collection by Wyndham
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent
"This is a very well maitained, safe, and comfortable property. If available, I would definately stay here again."
Chauntine 3-night trip
Posted 9 hours ago
Holiday Inn Express & Suites Louisville Downtown by IHG
Omni Louisville Hotel

Omni Louisville Hotel

10/10 Excellent
"Extremely nice property downtown close to the KFC arena."
Empire Transportation LLC 2-night trip
Posted 11 hours ago
Omni Louisville Hotel
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent
"Nice rooms and the staff was great! If I had to nitpick, the elevator is pretty slow."
Justin 1-night trip
Posted 13 hours ago
Cambria Hotel Louisville Downtown-Whiskey Row
Hyatt Regency Louisville

Hyatt Regency Louisville

10/10 Excellent
"Clean rooms, good room service, amazing on site restaraunt and bar. In door pool is kinda small but clean"
Pavel 1-night trip
Posted 13 hours ago
Hyatt Regency Louisville
The Grady

The Grady

10/10 Excellent
"Nice place. Fantastic location. Next to major distilleries and bars."
Joerg 1-night trip
Posted 20 hours ago
The Grady
Moxy Louisville Downtown

Moxy Louisville Downtown

8/10 Good
"No way to get hot water for tea for guests."
David 1-night trip
Posted 2 days ago
Moxy Louisville Downtown
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent
"Great location. Nice property. Will use again."
David 2-night trip
Posted 2 days ago
Towneplace Suites By Marriott Louisville Downtown
Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown

10/10 Excellent
"Super easy to walk to a bunch of distilleries and also get to great restaurants and speakeasies."
Myong 1-night trip
Posted 2 days ago
Aloft by Marriott Louisville Downtown

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A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)
Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
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The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.
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Evan Williams Bourbon Experience

8.6/10 (20 reviews)
You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.
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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
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Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.
What's the best place to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.
How many hotels will I find close to 21c Museum Hotel?
Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.
Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?
For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center, or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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