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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A living room with a sofa, armchair, coffee table, fireplace, and large windows.
A covered outdoor seating area with wicker furniture and a wooden railing.
A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Roy
￥44,041
￥51,119 total
includes taxes & fees
Oct 19 - Oct 20
Louisville Bourbon Inn
A wooden staircase with a balustrade leading to a landing.
A brick building with a covered porch, columns, and potted plants.
A bedroom with a bed, a dresser, a television, and a desk with a lamp.
A dining area with brick walls, wooden shelves, and tables set for a meal.

2. Market Street Inn

Market Street Inn
2.1 km from 21c Museum Hotel
United States
Holly
￥30,879
￥34,893 total
includes taxes & fees
Oct 13 - Oct 14
Market Street Inn
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling, large windows, and classic furniture.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

3. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
Meghan
￥21,191
￥24,932 total
includes taxes & fees
Oct 28 - Oct 29
The Brown Hotel
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
A living room with a sofa, a fireplace, a staircase, and a chandelier.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.
A room with a red velvet sofa, a blue armchair, and a small round table with books.

4. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from 21c Museum Hotel
United States
Casey
￥28,754
￥33,375 total
includes taxes & fees
Oct 14 - Oct 15
DuPont Mansion Bed & Breakfast
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A bar with shelves of liquor bottles and a bartender preparing drinks.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

5. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Anthony
￥37,380
￥43,981 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Distil, Autograph Collection
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.
A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

6. Stellar Suites

Stellar Suites
East Market District, 2.2 km from 21c Museum Hotel
United States
Kevin
￥15,521
￥26,260 total
includes taxes & fees
Oct 18 - Oct 19
Stellar Suites
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A building with a sign reading "THE GRADY" at the entrance.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

7. The Grady

The Grady
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Bruce
￥24,397
￥28,704 total
includes taxes & fees
Oct 18 - Oct 19
The Grady
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A steam fountain in a brick alleyway.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

8. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 km from 21c Museum Hotel
United States
Matt
￥28,044
￥33,786 total
includes taxes & fees
Oct 26 - Oct 27
21c Museum Hotel Louisville
A modern bar area with a circular bar, multiple seating options, and a large screen.
A modern lobby with a fireplace, seating area, and a reception desk.
A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

9. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from 21c Museum Hotel
United States
William
￥16,442
￥19,346 total
includes taxes & fees
Oct 29 - Oct 30
Cambria Hotel Louisville Downtown-Whiskey Row
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A modern hotel room with a large bed, a city view, and a unique headboard design.

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Cameron
￥28,357
￥33,365 total
includes taxes & fees
Oct 12 - Oct 13
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A spacious lobby with a large seating area, a chandelier, and a patterned rug.
A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.
A swimming pool with lounge chairs and a view of the city.

11. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, 0.1 km from 21c Museum Hotel
United States
Kelly
￥19,286
￥22,692 total
includes taxes & fees
Oct 25 - Oct 26
Homewood Suites by Hilton Louisville Downtown, KY
A covered patio with a stone wall, a glass table, and a bench.
Staircase
A garden pathway with a lantern, potted plants, and a white fence.
A stone house with a balcony, a front door, and a staircase leading to the entrance.

12. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 2.9 km from 21c Museum Hotel
United States
Brittany
￥24,800
￥28,785 total
includes taxes & fees
Oct 7 - Oct 8
Central Park Bed & Breakfast
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

13. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from 21c Museum Hotel
United States
Saud
￥22,910
￥26,956 total
includes taxes & fees
Oct 25 - Oct 26
Galt House Hotel Trademark Collection by Wyndham
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A yellow coffee shop counter with a menu board above, displaying various coffee and food items.
A brightly lit grocery store with yellow shelving and a central checkout counter.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

14. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 2 km from 21c Museum Hotel
United States
Tyler
￥23,993
￥28,230 total
includes taxes & fees
Oct 26 - Oct 27
Hotel Genevieve part of JdV by Hyatt
A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.
A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.
A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.
A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

15. AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
East Market District, 2 km from 21c Museum Hotel
United States
Jen
￥22,588
￥26,578 total
includes taxes & fees
Oct 25 - Oct 26
AC Hotel Louisville Downtown
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.
A modern bar area with glass partitions, bar stools, and a variety of bottles.
A reception area with marble counters, modern pendant lighting, and potted orchids.

16. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville, 0.7 km from 21c Museum Hotel
United States
Veronica
￥36,517
￥42,965 total
includes taxes & fees
Oct 17 - Oct 18
Louisville Marriott Downtown
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.
A modern hotel room with a living area, a dining area, and a bedroom.
A hotel dining area with long tables, booths, and a bar.
A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

17. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
Frances
￥23,169
￥27,261 total
includes taxes & fees
Oct 29 - Oct 30
Embassy Suites Louisville Downtown
A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.
A bakery display with pastries and bread, a coffee station, and a Christmas tree in the background.
A spacious living room with a fireplace, wooden paneling, a television, and a blue sofa.
A grand lobby with marble floors, a staircase, and a reception desk.

18. Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
Downtown Louisville, 0.8 km from 21c Museum Hotel
United States
DAVID
￥26,005
￥30,598 total
includes taxes & fees
Oct 29 - Oct 30
Seelbach Hilton Louisville Downtown
A spacious lobby with leather sofas, round tables, and ottomans, featuring large windows and modern lighting fixtures.
A conference room with a large table, multiple chairs, a projector screen, and a small bar area.
A hotel with a brick facade, multiple floors, and a prominent signage.
A grocery store with refrigerated freezers, shelves stocked with beverages, snacks, and household items.

19. Residence Inn by Marriott Louisville Downtown

Residence Inn by Marriott Louisville Downtown
Downtown Louisville, 1.3 km from 21c Museum Hotel
United States
Kooper
￥17,206
￥20,244 total
includes taxes & fees
Oct 25 - Oct 26
Residence Inn by Marriott Louisville Downtown
A spacious lobby with a central escalator, comfortable seating areas, and modern lighting fixtures.
A modern hotel exterior with outdoor seating, a glass canopy, and a visible sign for the Hyatt Regency.
An outdoor seating area with wicker furniture, wooden tables, and large lamps.
A modern lobby with a central seating area, an escalator, and a staircase.

20. Hyatt Regency Louisville

Hyatt Regency Louisville
Downtown Louisville, 0.6 km from 21c Museum Hotel
United States
Lester
￥25,414
￥29,902 total
includes taxes & fees
Oct 29 - Oct 30
Hyatt Regency Louisville
View all properties

Compare popular hotels close to 21c Museum Hotel

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
Louisville Bourbon Inn
10.0
Exceptional
25 reviews
View
A wooden staircase with a balustrade leading to a landing.
Market Street Inn
9.8
Exceptional
125 reviews
View
A grand lobby with ornate columns, plush seating, and a chandelier.
The Brown Hotel
9.4
Exceptional
1,343 reviews
View
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
148 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
508 reviews
View

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

The Brown Hotel

10/10 Excellent
"I will come back again"
Chris 1-night trip
Posted 1 hour ago
The Brown Hotel
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent
"The bed was very comfortable. The food was really good and the staff was very friendly."
AAIMEE 4-night trip
Posted 8 hours ago
Cambria Hotel Louisville Downtown-Whiskey Row
Omni Louisville Hotel

Omni Louisville Hotel

10/10 Excellent
"The beds… the beds were the most comfortable beds I’ve ever slept on"
Noel 5-night trip
Posted 12 hours ago
Omni Louisville Hotel
Louisville Marriott Downtown

Louisville Marriott Downtown

10/10 Excellent
"The room was clean and the hotel was in a great location."
Veronica 3-night trip
Posted 13 hours ago
Louisville Marriott Downtown
21c Museum Hotel Louisville

21c Museum Hotel Louisville

10/10 Excellent
"The room was wonderful. Usually sleep horribly in hotel but slept like a baby. Loved the pillows and mattress."
Tammy 1-night trip
Posted 18 hours ago
21c Museum Hotel Louisville
Hyatt Regency Louisville

Hyatt Regency Louisville

10/10 Excellent
"I love the look of this hotel. It's amazing to be able to look up 18 stories and then to go up to the 18th story and look down. All in all the hotel appears to be very well kept. However, I was surprised that at the top of the ceiling in the main atrium some of ceiling was hanging down possibly from water damage which took away from the beauty. Also the elevator door is looked worn in the main lobby on the outside. But other than that everything inside was great. Free fruit water in the lobby. I was not very impressed with the area. Same kind of rundown. I didn't feel entirely safe walking around but it wasn't terrible and it certainly not the hotel's fault. All in all a great experience. Good view as well."
Justin 1-night trip
Posted 21 hours ago
Hyatt Regency Louisville
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

8/10 Good
"The room was very clean. It had a small kitchen area. Unfortunately the icemaker did not work in the refrigerator. Other than that it was a great place to stay and I would definitely stay there again if I return to Louisville."
Jess 1-night trip
Posted 22 hours ago
Homewood Suites by Hilton Louisville Downtown, KY
Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown

10/10 Excellent
"Clean very accommodating the only thing I could say that needs updating is the lighting in the hallways. It was very dark."
Michael 2-night trip
Posted 1 day ago
Aloft by Marriott Louisville Downtown
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

10/10 Excellent
"Excellent stay"
Frances 5-night trip
Posted 2 days ago
Embassy Suites Louisville Downtown

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A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)
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The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
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Golden Statue of David

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Evan Williams Bourbon Experience

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SAR Genealogical Research Library: NSSAR Library

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Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.
What's the best place to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.
How many hotels will I find close to 21c Museum Hotel?
Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.
Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?
For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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