The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥43,770

￥50,805 total

includes taxes & fees

Oct 5 - Oct 6

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

2. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Melanie

￥22,237

￥26,164 total

includes taxes & fees

Sep 28 - Sep 29

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥28,577

￥33,169 total

includes taxes & fees

Oct 5 - Oct 6

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

4. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Cinda

￥18,700

￥22,003 total

includes taxes & fees

Oct 18 - Oct 19

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A swimming pool with lounge chairs and a view of the city.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

5. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Diane

￥22,512

￥26,487 total

includes taxes & fees

Oct 5 - Oct 6

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

6. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Maria

￥23,670

￥27,850 total

includes taxes & fees

Oct 5 - Oct 6

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

7. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Adam

￥38,623

￥45,445 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A building with a sign reading "THE GRADY" at the entrance.

8. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Bruce

￥27,415

￥32,257 total

includes taxes & fees

Oct 18 - Oct 19

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

9. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Benton

￥15,425

￥26,098 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern hotel room with a large bed, a city view, and a unique headboard design.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Breeana

￥33,318

￥39,202 total

includes taxes & fees

Sep 28 - Sep 29

An outdoor seating area with wicker furniture and a fire pit.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

A modern lounge area with seating, tables, and a view of the city through large windows.

11. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Scott

￥19,139

￥22,519 total

includes taxes & fees

Oct 11 - Oct 12

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

12. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Rebekah

￥23,911

￥28,133 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

13. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Saud

￥25,480

￥29,980 total

includes taxes & fees

Oct 5 - Oct 6

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

14. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,511

￥26,487 total

includes taxes & fees

Oct 4 - Oct 5

A covered patio with a stone wall, a glass table, and a bench.

A garden pathway with a lantern, potted plants, and a white fence.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

15. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Angie

￥24,648

￥28,609 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A hotel dining area with long tables, booths, and a bar.

A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

16. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Maurica

￥25,670

￥30,204 total

includes taxes & fees

Oct 11 - Oct 12

A modern interior with a curved wall featuring vertical lines and geometric patterns.

A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.

A modern lobby with a curved seating area, a red ottoman, and a television screen.

17. Holiday Inn Express & Suites Louisville Downtown by IHG

Downtown Louisville, 0.3 km from 21c Museum Hotel

Carlos

￥18,563

￥21,842 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a central escalator, comfortable seating areas, and modern lighting fixtures.

A modern lobby with a central seating area, an escalator, and a staircase.

A modern living room with a sofa, armchairs, a coffee table, and a dining area with a table and chairs.

An outdoor seating area with wicker furniture, wooden tables, and large lamps.

18. Hyatt Regency Louisville

Downtown Louisville, 0.6 km from 21c Museum Hotel

Sandra

￥28,001

￥32,946 total

includes taxes & fees

Oct 15 - Oct 16

A modern kitchen with wooden cabinets, a long countertop, and a variety of food items displayed.

A modern lobby with a curved ceiling, a black sofa with red cushions, a red chair, and a small yellow table.

A multi-story hotel with a prominent signage for SpringHill Suites Marriott.

A hotel room with two beds, a TV, and a desk.

19. SpringHill Suites by Marriott Louisville Downtown

Downtown Louisville, 1 km from 21c Museum Hotel

Beau

￥18,586

￥21,867 total

includes taxes & fees

Oct 12 - Oct 13

A Courtyard by Marriott hotel with a modern brick facade, multiple floors, and a prominent sign.

A modern bistro with a wooden counter, menu boards, and seating area with tables and chairs.

An outdoor patio area with wicker furniture, including sofas and a coffee table, surrounded by a black metal fence.

A modern living room with a fireplace, comfortable seating, and a large TV.

20. Courtyard by Marriott Louisville Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

sabrina

￥21,612

￥25,429 total

includes taxes & fees

Oct 1 - Oct 2

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
The Brown Hotel	9.4 Exceptional 1,313 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 147 reviews	View
Cambria Hotel Louisville Downtown-Whiskey Row	9.4 Exceptional 1,009 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	9.4 Exceptional 1,009 reviews	View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Thanks"

Moxy Louisville Downtown

8/10 Good

"No way to get hot water for tea for guests."

The Brown Hotel

10/10 Excellent

"Wonderful historic hotel. Great location, incredible staff. Rooms were lovely and the whole place was spotless. Will definitely stay here again."

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"Great location. Nice property. Will use again."

Omni Louisville Hotel

10/10 Excellent

"Wonderful hotel with excellent amenities. Comfortable and clean rooms. We’ll be back next time we’re in Louisville."

Radisson Hotel Louisville North

10/10 Excellent

"."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"Super easy to walk to a bunch of distilleries and also get to great restaurants and speakeasies."

Hyatt Regency Louisville

8/10 Good

"Was close to all activities walking distance"

Embassy Suites Louisville Downtown

10/10 Excellent

"The breakfast service was exceptional. The property is ideally situated, with a wide array of dining options and entertainment venues within convenient walking distance."

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Find hotels near 21c Museum Hotel, Louisville from ￥21,842

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. The Brown Hotel

3. DuPont Mansion Bed & Breakfast

4. Cambria Hotel Louisville Downtown-Whiskey Row

5. Homewood Suites by Hilton Louisville Downtown, KY

6. Tempo By Hilton Louisville Downtown Nulu

7. Hotel Distil, Autograph Collection

8. The Grady

9. Stellar Suites

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

11. Towneplace Suites By Marriott Louisville Downtown

12. Hotel Genevieve part of JdV by Hyatt

13. Galt House Hotel Trademark Collection by Wyndham

14. AC Hotel Louisville Downtown

15. Central Park Bed & Breakfast

16. Embassy Suites Louisville Downtown

17. Holiday Inn Express & Suites Louisville Downtown by IHG

18. Hyatt Regency Louisville

19. SpringHill Suites by Marriott Louisville Downtown

20. Courtyard by Marriott Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Moxy Louisville Downtown

The Brown Hotel

Towneplace Suites By Marriott Louisville Downtown

Omni Louisville Hotel

Radisson Hotel Louisville North

Aloft by Marriott Louisville Downtown

Hyatt Regency Louisville

Embassy Suites Louisville Downtown

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

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