The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

Q: What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

Q: What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel .

Q: How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

Q: If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Q: Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here .

Q: What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

A wooden staircase with a balustrade leading to a landing.

1. Market Street Inn

2.1 km from 21c Museum Hotel

"Such a lovely stay at the Market Street Inn. A very charming, comfortable and feels like home kind of place. Carol and Steve are just the kindest owners. They were responsive and accommodating and always available if needed. We also loved meeting Lisa, who made breakfast each morning and took care of any housekeeping needs. We felt like we were treated as family and not just guests. The area and location is perfect, SUCH a cute little town. Plenty of restaurants, shops and entertainment within...

Ryan

￥39,909 total

includes taxes & fees

Nov 15 - Nov 16

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

2. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Athina

￥37,868 total

includes taxes & fees

Nov 28 - Nov 29

A grand hotel lobby with ornate ceiling designs, a central staircase, and a dining area.

3. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Brianne

￥20,026 total

includes taxes & fees

Nov 24 - Nov 25

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

4. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Jeanette

￥21,420 total

includes taxes & fees

Nov 28 - Nov 29

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

5. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

James

￥33,410 total

includes taxes & fees

Nov 22 - Nov 23

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

6. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Greg

￥27,866 total

includes taxes & fees

Nov 23 - Nov 24

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

7. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Chris

￥33,767 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

8. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥19,128 total

includes taxes & fees

Nov 25 - Nov 26

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

9. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥27,053 total

includes taxes & fees

Nov 23 - Nov 24

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

10. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Erick

￥29,420 total

includes taxes & fees

Dec 6 - Dec 7

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Paul

￥27,614 total

includes taxes & fees

Nov 29 - Nov 30

A modern bar area with a circular bar, multiple seating options, and a large screen.

12. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Trista

￥17,889 total

includes taxes & fees

Dec 14 - Dec 15

An outdoor seating area with wicker furniture and a fire pit.

13. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Brandi

￥18,228 total

includes taxes & fees

Dec 15 - Dec 16

A covered patio with a stone wall, a glass table, and a bench.

14. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Stephen

￥31,026 total

includes taxes & fees

Nov 22 - Nov 23

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

15. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Priscilla

￥20,859 total

includes taxes & fees

Dec 14 - Dec 15

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

16. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Anthony

￥22,985 total

includes taxes & fees

Nov 28 - Nov 29

An outdoor dining area with a long table and wicker chairs, overhead lighting, and a view of the city.

17. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Brittney

￥26,892 total

includes taxes & fees

Nov 22 - Nov 23

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

18. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Kevin

￥26,892 total

includes taxes & fees

Nov 21 - Nov 22

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

19. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Shun

￥24,346 total

includes taxes & fees

Nov 28 - Nov 29

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

20. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Ernest P

￥22,986 total

includes taxes & fees

Nov 23 - Nov 24

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Market Street Inn	3.5 star property	9.8 Exceptional 127 reviews	View
Hotel Distil, Autograph Collection	4.0 star property	9.6 Exceptional 520 reviews	View
The Brown Hotel	4.5 star property	9.4 Exceptional 1,481 reviews	View
Homewood Suites by Hilton Louisville Downtown, KY	3.0 star property	9.4 Exceptional 1,004 reviews	View
Omni Louisville Hotel	4.0 star property	9.4 Exceptional 2,237 reviews	View

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

8/10 Good

"Very nice older hotel. Breakfast was amazing!!!"

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good

"The property was in a perfect location from whiskey row. Everything was great except for the toliet could have used some deep cleaning as under the rim was a bit nasty, crumbs on the desk chair and a medication pill next to the bed. They did supply toothpaste that was not packed and the breakfast was a typical buffet type. Nothing special . We did appreciate that was included though . Over all i would stay here again."

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"This was one of the best moderate price hotels in which we’ve ever stayed. The hotel was beautifully decorated; room was spacious and comfortable; staff were great and breakfast was exceptional with a huge variety with lots of toppings and touches. Location was perfect as well for our downtown walking exploration."

Embassy Suites Louisville Downtown

10/10 Excellent

"The cooked to order breakfast buffet on the third floor is outstanding. One of the best ever at an Embassy Suites that I have ever attended. The valet parking at $50 a night was very expensive, but it was adequate for us since we were doing a move and we had a loaded van of household items and were concerned about security and safety."

Holiday Inn Louisville Downtown by IHG

10/10 Excellent

"Property was clean and well kept. The valet parking did not make much sense to me though. I do not mind valeting my car and always opt to do so when traveling out of town if needed. However, most valet lots are private from public parking where the cars are not easily accessible. Here the valet lot is essentially an open lot I could have parked my car in on my own. Adding to this anybody could have gotten to or from our car at any point and time. Most nights we ended up parking our cars ourselves and then turning the keys over to the valet drivers, and the same thing when we needed to leave in the morning, we retrieved our keys from the valet driver and went and got out own vehicles, again entirely defeating the purpose of valet parking. Other than the parking there are no complaints about our stay."

Towneplace Suites By Marriott Louisville Downtown

8/10 Good

"Check in and check out we’re a breeze. The front desk staff was very helpful and knowledgeable. Breakfast selection was great and hot tea and coffee hot cocoa always was available in the lobby. Close walk to slugger museum and bourbon tours. Parking is $24 a night but close by and secured. Will def stay here again!"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

1. Market Street Inn

2. Hotel Distil, Autograph Collection

3. The Brown Hotel

4. Homewood Suites by Hilton Louisville Downtown, KY

5. Omni Louisville Hotel

6. The Grady

7. DuPont Mansion Bed & Breakfast

8. Tempo By Hilton Louisville Downtown Nulu

9. Stellar Suites

10. 21c Museum Hotel Louisville

11. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

12. Cambria Hotel Louisville Downtown-Whiskey Row

13. Towneplace Suites By Marriott Louisville Downtown

14. Central Park Bed & Breakfast

15. Moxy Louisville Downtown

16. Aloft by Marriott Louisville Downtown

17. Hotel Genevieve part of JdV by Hyatt

18. AC Hotel Louisville Downtown

19. Galt House Hotel Trademark Collection by Wyndham

20. Embassy Suites Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

Other attractions near 21c Museum Hotel

Louisville Science Center

Frequently asked questions

Explore a world of travel with Expedia