The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥44,224

￥51,332 total

includes taxes & fees

Oct 25 - Oct 26

A wooden staircase with a balustrade leading to a landing.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A two-story brick building with a white porch and a sign reading "Hotel".

2. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

￥35,051

￥39,608 total

includes taxes & fees

Oct 25 - Oct 26

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥25,698

￥29,829 total

includes taxes & fees

Nov 19 - Nov 20

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand lobby with ornate ceiling, large windows, and classic furniture.

4. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

John

￥22,244

￥26,172 total

includes taxes & fees

Nov 19 - Nov 20

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

A bar with shelves of liquor bottles and a bartender preparing drinks.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

5. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

￥36,128

￥42,507 total

includes taxes & fees

Nov 8 - Nov 9

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A swimming pool with lounge chairs and a view of the city.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

peter

￥18,305

￥21,537 total

includes taxes & fees

Nov 11 - Nov 12

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

7. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥18,717

￥22,021 total

includes taxes & fees

Oct 29 - Oct 30

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

8. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

￥18,331

￥29,556 total

includes taxes & fees

Oct 26 - Oct 27

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

9. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥25,465

￥30,755 total

includes taxes & fees

Nov 15 - Nov 16

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

10. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Sarah

￥16,358

￥19,247 total

includes taxes & fees

Nov 10 - Nov 11

A brick building with outdoor seating and a fire pit.

A modern hotel room with a sofa, a small desk, a microwave, and a TV.

A modern bar area with a wooden counter, bar stools, and a variety of bottles and glasses.

An indoor swimming pool with clear water, surrounded by blue chairs and tables, and a tiled floor.

11. TownePlace Suites by Marriott Louisville North

2.2 km from 21c Museum Hotel

Lori M

￥24,411

￥27,584 total

includes taxes & fees

Oct 27 - Oct 28

A covered patio with a stone wall, a glass table, and a bench.

A grand room with a fireplace, a staircase, and a chandelier.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

12. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

￥24,091

￥27,962 total

includes taxes & fees

Oct 25 - Oct 26

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A brightly lit grocery store with yellow shelving and a central checkout counter.

13. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

￥23,301

￥27,415 total

includes taxes & fees

Nov 8 - Nov 9

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

14. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Anthony

￥20,785

￥24,455 total

includes taxes & fees

Nov 15 - Nov 16

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A balcony with a view of a river, a bridge, and a cityscape.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

15. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Judy

￥22,225

￥26,150 total

includes taxes & fees

Nov 8 - Nov 9

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

16. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,683

￥26,688 total

includes taxes & fees

Oct 30 - Oct 31

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

A modern hotel room with a living area, a dining area, and a bedroom.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

17. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Frances

￥23,187

￥27,280 total

includes taxes & fees

Nov 15 - Nov 16

A modern lobby with a central seating area, a reception desk, and a large screen.

A modern interior with a curved wall featuring vertical lines and geometric patterns.

A modern lobby with a curved sofa, a round orange ottoman, and a seating area with chairs and a table.

A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.

18. Holiday Inn Express & Suites Louisville Downtown by IHG

Downtown Louisville, 0.3 km from 21c Museum Hotel

Sarah

￥18,070

￥21,262 total

includes taxes & fees

Nov 17 - Nov 18

A spacious lobby with leather sofas, round tables, and ottomans, featuring large windows and modern lighting fixtures.

A swimming pool with a tiled deck, green chairs, and a table.

A grocery store with refrigerated freezers, shelves stocked with beverages, snacks, and household items.

A conference room with a large table, multiple chairs, a projector screen, and a small bar area.

19. Residence Inn by Marriott Louisville Downtown

Downtown Louisville, 1.3 km from 21c Museum Hotel

Kooper

￥16,327

￥19,211 total

includes taxes & fees

Nov 8 - Nov 9

A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.

A grand staircase with ornate railings and a marble floor, leading to a high-ceilinged lobby with decorative moldings and a chandelier.

A spacious living room with a fireplace, wooden paneling, a television, and a blue sofa.

A grand lobby with marble floors, a staircase, and a reception desk.

20. Seelbach Hilton Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Colleen

￥24,645

￥28,997 total

includes taxes & fees

Nov 20 - Nov 21

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 125 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 150 reviews	View
The Brown Hotel	9.4 Exceptional 1,400 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 511 reviews	View

Top 21c Museum Hotel Hotel Reviews

Holiday Inn Louisville Downtown by IHG

10/10 Excellent

"Very clean, modern facility for a quick overnight. I did not use many of the amenities due to the shortness of my stay. Staff was very friendly and helpful."

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good

"Loved the area and the staff"

21c Museum Hotel Louisville

10/10 Excellent

"All good."

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"Good location. Walkable to many restaurants and bars. Coffee shop on the bottom level and bar on the second floor with TV’s to watch football."

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"A five star hotel with a three star budget. This place was wonderful in all ways. So thankful to have found them"

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"déjeuner hors pair en plus de l'endroit propre et agréable"

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Great place to stay at"

The Grady

10/10 Excellent

"Lovely boutique hotel. Great location, very nice staff. Only issue was trying to get into on-site restaurant which was always booked up."

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent

"Great location- super responsive host - clean and great view of the river."

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

See properties

A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

See properties

A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

See properties

Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

See properties

Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum, or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

Explore a world of travel with Expedia

Louisville Vacations

Kentucky Vacation Rentals

Find hotels near 21c Museum Hotel, Louisville from ￥18,296

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. DuPont Mansion Bed & Breakfast

4. The Brown Hotel

5. Hotel Distil, Autograph Collection

6. Homewood Suites by Hilton Louisville Downtown, KY

7. Tempo By Hilton Louisville Downtown Nulu

8. Stellar Suites

9. 21c Museum Hotel Louisville

10. Cambria Hotel Louisville Downtown-Whiskey Row

11. TownePlace Suites by Marriott Louisville North

12. Central Park Bed & Breakfast

13. Hotel Genevieve part of JdV by Hyatt

14. Aloft by Marriott Louisville Downtown

15. Galt House Hotel Trademark Collection by Wyndham

16. AC Hotel Louisville Downtown

17. Embassy Suites Louisville Downtown

18. Holiday Inn Express & Suites Louisville Downtown by IHG

19. Residence Inn by Marriott Louisville Downtown

20. Seelbach Hilton Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Holiday Inn Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

21c Museum Hotel Louisville

Cambria Hotel Louisville Downtown-Whiskey Row

Homewood Suites by Hilton Louisville Downtown, KY

Towneplace Suites By Marriott Louisville Downtown

Galt House Hotel Trademark Collection by Wyndham

The Grady

Suite 7 City Loft Escape with River Views! By Hollyhock

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

Explore a world of travel with Expedia