The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

A bar with shelves of liquor bottles and a bartender preparing drinks.

1. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Adam

￥38,976

￥45,858 total

includes taxes & fees

Oct 11 - Oct 12

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

2. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥28,650

￥33,254 total

includes taxes & fees

Sep 28 - Sep 29

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

3. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Meghan

￥22,176

￥26,094 total

includes taxes & fees

Oct 27 - Oct 28

A modern bar area with a circular bar, multiple seating options, and a large screen.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

4. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Erin

￥15,418

￥18,140 total

includes taxes & fees

Oct 25 - Oct 26

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A modern restaurant interior with a staircase, round tables, and a brick wall.

5. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Bruce

￥27,484

￥32,338 total

includes taxes & fees

Oct 11 - Oct 12

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

6. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥25,505

￥30,804 total

includes taxes & fees

Oct 26 - Oct 27

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A modern interior with a fireplace, bookshelves, and seating areas.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

7. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Travis

￥43,913

￥51,669 total

includes taxes & fees

Oct 24 - Oct 25

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

8. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Benton

￥15,464

￥26,166 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern hotel room with a large bed, a city view, and a unique headboard design.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Cameron

￥33,715

￥39,668 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

10. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

￥19,396

￥22,822 total

includes taxes & fees

Oct 4 - Oct 5

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

11. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Bryan

￥20,132

￥23,687 total

includes taxes & fees

Oct 18 - Oct 19

A brick building with outdoor seating and a fire pit.

A modern restaurant with wooden furniture, a central island, and a high ceiling.

A modern hotel room with a sofa, a small desk, a microwave, and a TV.

An indoor swimming pool with clear water, surrounded by blue chairs and tables, and a tiled floor.

12. TownePlace Suites by Marriott Louisville North

2.2 km from 21c Museum Hotel

Lisa

￥19,209

￥21,705 total

includes taxes & fees

Oct 15 - Oct 16

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

13. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Angela

￥21,052

￥24,770 total

includes taxes & fees

Oct 4 - Oct 5

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A brightly lit grocery store with yellow shelving and a central checkout counter.

14. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

￥22,860

￥26,898 total

includes taxes & fees

Oct 26 - Oct 27

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

15. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,717

￥26,729 total

includes taxes & fees

Oct 4 - Oct 5

A covered patio with a stone wall, a glass table, and a bench.

A grand room with a fireplace, a staircase, and a chandelier.

A garden pathway with a lantern, potted plants, and a white fence.

16. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Brittany

￥24,711

￥28,681 total

includes taxes & fees

Oct 5 - Oct 6

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

17. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Saud

￥23,655

￥27,832 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

A hotel dining area with long tables, booths, and a bar.

A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

18. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Maurica

￥23,933

￥28,160 total

includes taxes & fees

Oct 27 - Oct 28

A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.

A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.

A reception area with marble counters, modern pendant lighting, and potted orchids.

A modern bar area with glass partitions, bar stools, and a variety of bottles.

19. Louisville Marriott Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

Jacobi

￥33,995

￥39,999 total

includes taxes & fees

Oct 12 - Oct 13

A historic hotel with ornate architecture, a grand entrance, and a red carpet leading to the doors.

A grand lobby with marble floors, a staircase, and a reception desk.

A bakery display with pastries and bread, a coffee station, and a Christmas tree in the background.

A spacious living room with a fireplace, wooden paneling, a television, and a blue sofa.

20. Seelbach Hilton Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

DAVID

￥29,421

￥34,617 total

includes taxes & fees

Oct 5 - Oct 6

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Hotel Distil, Autograph Collection	9.6 Exceptional 506 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 147 reviews	View
The Brown Hotel	9.4 Exceptional 1,327 reviews	View
Cambria Hotel Louisville Downtown-Whiskey Row	9.4 Exceptional 1,016 reviews	View
The Grady	9.4 Exceptional 1,010 reviews	View

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

10/10 Excellent

"Really enjoyed our stay. The staff was very helpful."

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Best bang for your buck in downtown Louisville."

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"Huge room was clean and quiet. Good location. Comfortable bed and nice linens Only complaint was when we checked in no one gave us any area information or said that we had to request housekeeping. We assumed it was every other day. On day 3 I asked and she said “oh you have to request it at check in” information we could have used! When I checked out a lovely lady was very sweet and helpful. I think her name was Ms"

Holiday Inn Louisville Downtown by IHG

10/10 Excellent

"Everything was great except for the laundry takes quarters and the front desk cant provide them and none of the nearby stores could give out quarters either"

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"Pleasantly surprised how nice this hotel was. Rooms were very clean and comfortable. Front desk was always pleasant and helpful! Would definitely stay there again and walking distance to so many great things to do, eat and drink!"

Omni Louisville Hotel

10/10 Excellent

"Everything we needed was on-site. The Falls Market restaurant and store were very helpful for food and other things we needed. Valet staff was friendly and helpful. Only complaints- hot tub was broken and neither front desk or guest services answered the phone the couple of times I tried to call."

Embassy Suites Louisville Downtown

10/10 Excellent

"Great stay for LTL and visiting restaurants."

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent

"Walking to Louisville Slugger and Muhammad Ali museum .Safe area to walk. Nice restaurants. Nice breakfast"

Hyatt Regency Louisville

10/10 Excellent

"Clean rooms, good room service, amazing on site restaraunt and bar. In door pool is kinda small but clean"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center, or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

1. Hotel Distil, Autograph Collection

2. DuPont Mansion Bed & Breakfast

3. The Brown Hotel

4. Cambria Hotel Louisville Downtown-Whiskey Row

5. The Grady

6. 21c Museum Hotel Louisville

7. Omni Louisville Hotel

8. Stellar Suites

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

10. Tempo By Hilton Louisville Downtown Nulu

11. Moxy Louisville Downtown

12. TownePlace Suites by Marriott Louisville North

13. Aloft by Marriott Louisville Downtown

14. Hotel Genevieve part of JdV by Hyatt

15. AC Hotel Louisville Downtown

16. Central Park Bed & Breakfast

17. Galt House Hotel Trademark Collection by Wyndham

18. Embassy Suites Louisville Downtown

19. Louisville Marriott Downtown

20. Seelbach Hilton Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

Galt House Hotel Trademark Collection by Wyndham

Cambria Hotel Louisville Downtown-Whiskey Row

Holiday Inn Louisville Downtown by IHG

Homewood Suites by Hilton Louisville Downtown, KY

Omni Louisville Hotel

Embassy Suites Louisville Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

Hyatt Regency Louisville

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

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