The Best Hotels Closest to 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

￥43,889

￥50,943 total

includes taxes & fees

Oct 5 - Oct 6

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

2. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

￥28,656

￥33,261 total

includes taxes & fees

Oct 5 - Oct 6

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

A grand lobby with ornate ceiling, large windows, and classic furniture.

3. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Melanie

￥22,299

￥26,238 total

includes taxes & fees

Sep 28 - Sep 29

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern lobby with a fireplace, seating area, and a reception desk.

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

4. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Cinda

￥18,751

￥22,063 total

includes taxes & fees

Oct 18 - Oct 19

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

5. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Adam

￥38,657

￥45,484 total

includes taxes & fees

Oct 4 - Oct 5

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A swimming pool with lounge chairs and a view of the city.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Diane

￥22,344

￥26,290 total

includes taxes & fees

Oct 12 - Oct 13

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

7. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Maria

￥19,237

￥22,634 total

includes taxes & fees

Oct 4 - Oct 5

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A building with a sign reading "THE GRADY" at the entrance.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

8. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Bruce

￥27,514

￥32,373 total

includes taxes & fees

Oct 11 - Oct 12

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

9. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Benton

￥15,467

￥26,170 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A modern interior with a fireplace, bookshelves, and seating areas.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

10. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Gilbert

￥43,921

￥51,677 total

includes taxes & fees

Oct 2 - Oct 3

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

11. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

￥30,648

￥36,847 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern hotel room with a large bed, a city view, and a unique headboard design.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

12. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Breeana

￥33,439

￥39,343 total

includes taxes & fees

Sep 29 - Sep 30

An outdoor seating area with wicker furniture and a fire pit.

A modern lounge area with seating, tables, and a view of the city through large windows.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

13. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Scott

￥18,563

￥21,839 total

includes taxes & fees

Oct 18 - Oct 19

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

14. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Bryan

￥20,154

￥23,712 total

includes taxes & fees

Oct 11 - Oct 12

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

15. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

￥22,531

￥26,510 total

includes taxes & fees

Oct 4 - Oct 5

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern bar area with sofas, tables, and a bar stocked with bottles.

16. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

￥20,646

￥24,293 total

includes taxes & fees

Oct 4 - Oct 5

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A brightly lit grocery store with yellow shelving and a central checkout counter.

A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

17. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Rebekah

￥23,932

￥28,159 total

includes taxes & fees

Oct 4 - Oct 5

A covered patio with a stone wall, a glass table, and a bench.

A grand room with a fireplace, a staircase, and a chandelier.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

A garden pathway with a lantern, potted plants, and a white fence.

18. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Angie

￥24,716

￥28,687 total

includes taxes & fees

Oct 5 - Oct 6

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A balcony with a view of a river, a bridge, and a cityscape.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

19. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Saud

￥25,550

￥30,062 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A hotel dining area with long tables, booths, and a bar.

A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

20. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Maurica

￥25,693

￥30,230 total

includes taxes & fees

Oct 11 - Oct 12

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Compare popular hotels close to 21c Museum Hotel

Property	Star rating	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 147 reviews	View
The Brown Hotel	9.4 Exceptional 1,314 reviews	View
Cambria Hotel Louisville Downtown-Whiskey Row	9.4 Exceptional 1,009 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 505 reviews	View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"The directions for the parking could be a little more clear but we made it. Great location."

Holiday Inn Louisville Downtown by IHG

10/10 Excellent

"Great place highly recommend"

Radisson Hotel Louisville North

10/10 Excellent

"Great stay! Location was very convenient."

Omni Louisville Hotel

10/10 Excellent

"The check in/out was seamless, the valet was attentive and quick, the coffee shop in house was amazing, all staff we dealt with were extremely pleasant, and the pool/hot tub were phenomenal! 10/10 stay, would come again!"

The Brown Hotel

10/10 Excellent

"Classic clean and very historical"

Moxy Louisville Downtown

8/10 Good

"No way to get hot water for tea for guests."

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"Great location. Nice property. Will use again."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"Super easy to walk to a bunch of distilleries and also get to great restaurants and speakeasies."

Hyatt Regency Louisville

8/10 Good

"Was close to all activities walking distance"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its beautiful river views and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.

What's the best place to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels will I find close to 21c Museum Hotel?

Expedia has 292 hotels and other accommodations within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals near 21c Museum Hotel.

Where can I learn more about changing or cancelling my trip in the area near 21c Museum Hotel?

For additional details about updating your stay near 21c Museum Hotel or cancelling it, click here.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center, or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall if you're interested in local theater.

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. DuPont Mansion Bed & Breakfast

3. The Brown Hotel

4. Cambria Hotel Louisville Downtown-Whiskey Row

5. Hotel Distil, Autograph Collection

6. Homewood Suites by Hilton Louisville Downtown, KY

7. Tempo By Hilton Louisville Downtown Nulu

8. The Grady

9. Stellar Suites

10. Omni Louisville Hotel

11. 21c Museum Hotel Louisville

12. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

13. Towneplace Suites By Marriott Louisville Downtown

14. Moxy Louisville Downtown

15. AC Hotel Louisville Downtown

16. Aloft by Marriott Louisville Downtown

17. Hotel Genevieve part of JdV by Hyatt

18. Central Park Bed & Breakfast

19. Galt House Hotel Trademark Collection by Wyndham

20. Embassy Suites Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Holiday Inn Louisville Downtown by IHG

Radisson Hotel Louisville North

Omni Louisville Hotel

The Brown Hotel

Moxy Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown

Hyatt Regency Louisville

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions

Explore a world of travel with Expedia