A serene lake with trees reflecting in the water, surrounded by a forest of tall, slender trees with autumn foliage.

Vacation Rentals in Orangeburg County

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Our top choices for Orangeburg County vacation rentals

A covered patio with outdoor furniture, a view of a lake, and a sunset.

1. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
9.0 out of 10, Wonderful, (7 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
The price is ￥29,613
￥76,907 total
includes taxes & fees
Oct 3 - Oct 4
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
A tent with a view of a lake and boats, a wooden chair, and a potted plant.

2. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (102 reviews)
"Love it"
United States
Mark
The price is ￥12,126
￥13,931 total
includes taxes & fees
Oct 27 - Oct 28
Bells Marina & Resort
A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

3. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (16 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is ￥36,195
￥79,829 total
includes taxes & fees
Oct 7 - Oct 8
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
A spacious living room with a large sofa, two coffee tables, and a potted plant.

4. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"This was our first long trip with our dog and she loved the place! Fenced in yard and home was cozy and dog friendly. Loved the farmhouse style and large bedrooms and baths. "
United States
Lori B.
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
A kitchen with wooden cabinets, a built-in dishwasher, a sink, and a ceiling fan.

5. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (36 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
The price is ￥12,039
￥25,593 total
includes taxes & fees
Oct 5 - Oct 6
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
A wooden deck with a white sofa, a wooden serving tray with snacks, and a pitcher of lemonade.

6. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (163 reviews)
"Had a great stay at this cute cottage, just what we needed to get away from the busy city!"
United States
Yevheniya R.
The price is ￥17,704
￥32,580 total
includes taxes & fees
Oct 7 - Oct 8
Pet friendly country cottage with large fenced-in yard & horses on property
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a gas stove.

7. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
The price is ￥23,369
￥44,109 total
includes taxes & fees
Oct 7 - Oct 8
Beautiful brick home w/ large porch and 3 bedrooms
A modern kitchen with white cabinets, stainless steel appliances, a black countertop, and a tiled floor.

8. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
The price is ￥27,540
￥51,706 total
includes taxes & fees
Oct 11 - Oct 12
Lake Marion Condo, Boat Slip Included, Pet Friendly
A kitchen with white cabinets, a central island with bar stools, a stove, and a sink.

9. Work Crews, Temporary Moves, Family Vacation

Work Crews, Temporary Moves, Family Vacation
North
9.8 out of 10, Exceptional, (8 reviews)
"Excellent helpful host for our 6 week stay. Very communicative and accommodating. Great place, perfect for what we needed. It was a perfect experience."
United States
Easy B.
The price is ￥28,413
￥60,635 total
includes taxes & fees
Oct 4 - Oct 5
Work Crews, Temporary Moves, Family Vacation
Beach

10. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (24 reviews)
"Everyone was pleased and said they would stay here again."
United States
Tom B.
The price is ￥18,727
￥28,124 total
includes taxes & fees
Oct 4 - Oct 5
Country Resting Spot just off I95. 12 miles west on hwy 6.
A kitchen with dark blue cabinets, a granite countertop, stainless steel sink, and a microwave.

11. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (15 reviews)
"Great stay!"
United States
Hayden S.
The price is ￥19,671
￥25,328 total
includes taxes & fees
Oct 4 - Oct 5
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
A living room with a sofa, two armchairs, a coffee table, and a lamp.

12. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is ￥19,671
￥30,744 total
includes taxes & fees
Oct 2 - Oct 3
Modern apartment overlooking historic downtown Elloree, SC.
A neatly made bed with white linens and patterned pillows, a bedside table with a lamp, and a remote control.

13. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
The price is ￥17,704
￥28,563 total
includes taxes & fees
Oct 2 - Oct 3
Quiet 1-bedroom apartment in charming Elloree, SC
A black recreational vehicle with a 'Timberwolf' logo, a sliding door entrance, and a small porch area with seating.

14. Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina

Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
Eutaw Springs
The price is ￥27,628
￥34,861 total
includes taxes & fees
Oct 4 - Oct 5
Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
A large, light-colored tent with string lights, set up on a gravel area near a body of water, with trees and a bridge in the background.

15. Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina

Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina
Eutaw Springs
The price is ￥23,322
￥33,068 total
includes taxes & fees
Oct 4 - Oct 5
Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina
A compact living space with a kitchen, dining area, and a small seating area.

16. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Very convenient to the lake."
United States
John P.
The price is ￥14,950
￥33,539 total
includes taxes & fees
Oct 7 - Oct 8
Country living lake style near Santee
A single-story building with a green metal roof, a wooden door, and a small attached shed.

17. Dome Tent Retreat with Private Wood-Fired Hot Tub in Branchville, South Carolina

Dome Tent Retreat with Private Wood-Fired Hot Tub in Branchville, South Carolina
Branchville
The price is ￥32,113
￥39,807 total
includes taxes & fees
Oct 4 - Oct 5
Dome Tent Retreat with Private Wood-Fired Hot Tub in Branchville, South Carolina
A cozy outdoor seating area with a sofa and chairs, a small table with drinks, and a view of the garden.

18. Gypsy camper

Gypsy camper
Hopkins
8.4 out of 10, Very good, (17 reviews)
"Great stay!"
United States
Jodi T.
The price is ￥13,849
￥30,492 total
includes taxes & fees
Oct 8 - Oct 9
Gypsy camper
Living area

19. Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
10.0 out of 10, Exceptional, (1 review)
"A Perfect Family Getaway!Our stay at this beautiful Summerton cabin was everything we hoped for and more. It provided the perfect opportunity to step back into a simpler time, unplug, and truly focus on making memories together as a family.The host family is wonderful. We purchased some of their farm-fresh goodies ahead of time, and having them waiting for us at the cabin when we arrived was a fantastic touch. A major highlight of our trip was getting to see all of the farm animals and the farm...
United States
Max N.
The price is ￥34,621
￥83,846 total
includes taxes & fees
Oct 13 - Oct 14
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Orangeburg County Hotel Reviews

Wyndham Garden Summerville

Wyndham Garden Summerville

10/10 Excellent
"Breakfast was great full array of items. Better than a lot of restaurant buffets."
demetro 1-night trip
Posted 3 hours ago
Wyndham Garden Summerville

Find out more about Orangeburg County

Vacation Apartments in Orangeburg County

Search for Vacation rentals in Orangeburg County on Expedia! You can easily find your home rentals, villas, Vacation apartments in Orangeburg County using one of the methods below:

  • View our selection of featured Vacation rentals in Orangeburg County
  • Use the map to find apartments and other Vacation homes in the Orangeburg County neighbourhood you prefer
  • Enter your travel dates to view the best deals on Vacation rentals in Orangeburg County while they last

Look no further and take a look at our great range of rental properties in Orangeburg County!