A street lined with historic buildings, palm trees, and a church tower with a clock.

Find Business Hotels in Daniel Island, SC

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Daniel Island Business Hotels

Tonight
Oct 6 - Oct 7
Tomorrow
Oct 7 - Oct 8
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Our top choices for Daniel Island business-friendly hotels

1. Home2 Suites by Hilton Charleston Daniel Island

Home2 Suites by Hilton Charleston Daniel Island
Charleston
United States
Layla
¥21,656
¥24,688 total
includes taxes & fees
Nov 1 - Nov 2
Home2 Suites by Hilton Charleston Daniel Island

2. The Beach Club at Charleston Harbor Resort and Marina

The Beach Club at Charleston Harbor Resort and Marina
Mount Pleasant
United States
Mollie
¥23,853
¥34,445 total
includes taxes & fees
Oct 27 - Oct 28
The Beach Club at Charleston Harbor Resort and Marina

3. Hotel Indigo Mount Pleasant by IHG

Hotel Indigo Mount Pleasant by IHG
Mount Pleasant
United States
Thomas
¥15,296
¥20,440 total
includes taxes & fees
Nov 3 - Nov 4
Hotel Indigo Mount Pleasant by IHG

4. Holiday Inn Express & Suites Mt. Pleasant by IHG

Holiday Inn Express & Suites Mt. Pleasant by IHG
Mount Pleasant
United States
Tami
¥20,055
¥23,020 total
includes taxes & fees
Oct 11 - Oct 12
Holiday Inn Express & Suites Mt. Pleasant by IHG

5. Cambria Hotel Mount Pleasant – Charleston

Cambria Hotel Mount Pleasant – Charleston
Mount Pleasant
United States
Fred V.
¥18,614
¥21,192 total
includes taxes & fees
Nov 1 - Nov 2
Cambria Hotel Mount Pleasant – Charleston

6. Tru by Hilton Mt Pleasant Charleston

Tru by Hilton Mt Pleasant Charleston
Mount Pleasant
United States
FELECIA
¥17,308
¥19,874 total
includes taxes & fees
Oct 19 - Oct 20
Tru by Hilton Mt Pleasant Charleston

7. DoubleTree by Hilton Charleston Mount Pleasant

DoubleTree by Hilton Charleston Mount Pleasant
Mount Pleasant
United States
Paul
¥16,588
¥19,059 total
includes taxes & fees
Nov 2 - Nov 3
DoubleTree by Hilton Charleston Mount Pleasant

8. Quality Inn Mt. Pleasant - Charleston

Quality Inn Mt. Pleasant - Charleston
Mount Pleasant
United States
Lori
¥14,013
¥16,152 total
includes taxes & fees
Nov 2 - Nov 3
Quality Inn Mt. Pleasant - Charleston

9. Starlight Motor Inn

Starlight Motor Inn
North Charleston
United States
barbara
¥16,468
¥18,773 total
includes taxes & fees
Oct 20 - Oct 21
Starlight Motor Inn

10. Hilton Garden Inn Charleston / Mt. Pleasant

Hilton Garden Inn Charleston / Mt. Pleasant
Mount Pleasant
United States
Susan
¥19,999
¥22,599 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Garden Inn Charleston / Mt. Pleasant
View all properties

Top Daniel Island Hotel Reviews

The Ryder Hotel

The Ryder Hotel

10/10 Excellent
"We liked the location. Would have like a more detailed info packet upon checking in of the hotel."
Jackie 2-night trip
Posted less than an hour ago
The Ryder Hotel
The Beach Club at Charleston Harbor Resort and Marina

The Beach Club at Charleston Harbor Resort and Marina

10/10 Excellent
"Phenomenal place to stay. The staff, the pool, the restaurant are simply unrivaled. I had an issue with the sliding door not locking and they immediately fixed it. The maintenance guy even stopped by to ensure I knew how to use the new lock. Kudos to him and the rest of the staff for going above and beyond. I met a couple bartenders at the restaurant Timone, and Brian. Once again, top notch service and recommendations. I would recommend this location vs anywhere else in the area"
Jonathan 1-night trip
Posted 4 hours ago
The Beach Club at Charleston Harbor Resort and Marina
Hotel Indigo Mount Pleasant by IHG

Hotel Indigo Mount Pleasant by IHG

10/10 Excellent
"Our overnight stay at the Hotel Indigo was fantastic. A family member had an early morning procedure at MUSC and it was super close to the hospital. The hotel was clean & beautiful, comfortable, and the front desk ladies were exceptional!! I gave the review 3 stars for the amenities solely because of our disappointing experience at the restaurant. The service was nonexistent. We arrived to the hotel around 6PM after driving for almost 2 hours. It was pouring rain, there were flooding advisories & we were not familiar with the area. We had to leave at 5:30AM to be at the hospital. Going to grab dinner was not ideal. After trying to find the restaurant phone number, I went down to the bar to place an order and wait on it. The bar staff never once acknowledged me and I never saw another waiter. I stood by the register at the bar, where 3 bartenders were back and forth. After a few minutes of standing there, another patron came up and asked if I was in line...I said yes. Again, the bartenders were right on the other side of the bar, using the register and serving other people. The bartenders came to her & helped her with what she needed, I assumed she was a regular and they knew what she needed. I was not addressed. I grabbed a menu from the bar near the register to look at it, and still I was never addressed. I tried to make eye contact indicating that I wanted to order. I ended up leaving without ever being spoken to. I'm hoping this is not always the experience."
Mallory 1-night trip
Posted 5 hours ago
Hotel Indigo Mount Pleasant by IHG
Drury Plaza Hotel North Charleston

Drury Plaza Hotel North Charleston

10/10 Excellent
"This hotel was incredible in every way… we would stay here anytime."
John 3-night trip
Posted 5 hours ago
Drury Plaza Hotel North Charleston
Tides Folly Beach, Charleston's Oceanfront Hotel

Tides Folly Beach, Charleston's Oceanfront Hotel

10/10 Excellent
"Good service. Helpful staff including a man who has been there for 18 years. Front desk was always available for suggestions as to dining. Wish they served breakfast."
Walter 1-night trip
Posted 6 hours ago
Tides Folly Beach, Charleston's Oceanfront Hotel
The Vendue

The Vendue

10/10 Excellent
"overall great stay"
Cathy 3-night trip
Posted 18 hours ago
The Vendue
Holiday Inn Express Charleston by IHG

Holiday Inn Express Charleston by IHG

10/10 Excellent
"The staff was excellent"
Laura 1-night trip
Posted 1 day ago
Holiday Inn Express Charleston by IHG

Frequently asked questions

Why book your business-friendly hotel in Daniel Island with Expedia?
With amenities like conference rooms, housekeeping and on-site restaurants, our business-friendly properties come with all you'll need to settle that big contract — and then put your feet up! Enter your preferred travel dates and destination and Expedia will help you plan the rest.
How can I find cheap business-friendly hotels in Daniel Island?
When work takes you on the road in Daniel Island, our "business friendly" filter will help you find the right hotel. From free WiFi to conference spaces and in-room desks, they have the amenities you need to be productive. You can also narrow your search by your preferred star rating and budget to view the most affordable accommodations.

Explore a world of travel with Expedia