A historic stone fortress with a central dome and surrounding walls.

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Check availability on Colon Luxury Hotels

Tonight
Oct 1 - Oct 2
Tomorrow
Oct 2 - Oct 3
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Colon luxury hotels

A hotel entrance with a central water feature, seating areas, and potted plants.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.
The entrance of The Santa Maria with a covered walkway and a view of the interior.

1. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
  • Elevate your Panama City escape with a Jack Nicklaus golf course, rejuvenating spa treatments, and poolside luxury at this 5-star retreat.
￥44,749
￥49,225 total
includes taxes & fees
Oct 4 - Oct 5
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.

2. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
  • Indulge in colonial elegance at this Panama City gem featuring a full-service spa, outdoor pool, and gourmet dining.
￥62,342
￥68,576 total
includes taxes & fees
Oct 6 - Oct 7
Sofitel Legend Casco Viejo, Panama City
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.
A modern hotel room with a dining area, a TV, and a city view.

3. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
  • Exclusive Panama City escape offers lavish poolside retreats and gourmet dining experiences.
￥21,669
￥23,836 total
includes taxes & fees
Oct 25 - Oct 26
Hotel Riu Plaza Panama
A poolside area with lounge chairs and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.

4. JW Marriott Panama

JW Marriott Panama
San Francisco
  • Unwind in opulent waterfront luxury with 4 pristine pools and ocean-view dining in Panama City.
￥40,176
￥44,194 total
includes taxes & fees
Oct 17 - Oct 18
JW Marriott Panama
A buffet with various food items including fruits, juices, and cheeses.
An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.
A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.
A gym with treadmills, weight machines, and dumbbells.

5. Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
San Antonio
￥15,932
￥17,525 total
includes taxes & fees
Oct 23 - Oct 24
Courtyard by Marriott Panama Metromall
A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
A rooftop lounge with modern seating and a panoramic city view.
A rooftop pool area with purple lounge chairs and a city skyline in the background.
A modern spa area with a hot tub, seating, and a city view.

6. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
  • Experience luxury and elegance in a Panamanian retreat with 2 restaurants, a spa, and casino.
￥25,286
￥27,815 total
includes taxes & fees
Oct 26 - Oct 27
Megapolis Hotel Panamá
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.

7. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
  • Panama City elegance at this Waldorf Astoria hotel with a full-service spa, outdoor pool, and refined dining in two upscale restaurants.
￥39,890
￥43,879 total
includes taxes & fees
Nov 1 - Nov 2
Waldorf Astoria Panama
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A high-rise building with a rooftop pool area, surrounded by other buildings.

8. W Panama

W Panama
Bella Vista
  • Lavish urban retreat offers 3 hot tubs, poolside luxury, and concierge services in Panama city.
￥36,398
￥40,038 total
includes taxes & fees
Nov 1 - Nov 2
W Panama
A restaurant with multiple dining tables, chairs, and a central water feature.
A historic building with ornate stonework and a balcony with plants.
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.
A rooftop terrace with tables and chairs, a view of two white towers, and a building with a large window.

9. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
Casco Viejo
  • Experience historic luxury in Panama's Casco Viejo district with 5 restaurants and a rooftop pool with spectacular views.
￥41,349
￥45,484 total
includes taxes & fees
Oct 9 - Oct 10
Hotel La Compañía Casco Antiguo
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.
A modern bar area with seating and a view of the city.

10. Hilton Panama

Hilton Panama
Bella Vista
  • Panama City sophistication meets relaxation with an attached winery, poolside dining, and a full-service spa offering couples' treatments.
￥39,136
￥43,050 total
includes taxes & fees
Oct 10 - Oct 11
Hilton Panama
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Top Colon Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Clean rooms, amazing staff and good breakfast"
Avanel 6-night trip
Posted less than an hour ago
Hotel Riu Plaza Panama
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

8/10 Good
"Overall it’s a great place to stay to experience the area. Good for hiking and fishing."
Nicholas 2-night trip
Posted 2 days ago
Gamboa Rainforest Reserve
Hotel Ojos del Rio

Hotel Ojos del Rio

8/10 Good
"No hot water in the shower."
charles 2-night trip
Posted 2 days ago
Hotel Ojos del Rio
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

8/10 Good
"Muy bien ubicado.................."
ariel 1-night trip
Posted 4 days ago
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Frequently asked questions

Are you looking for a luxury hotel for your Colon vacation?
Use Expedia to arrange your flight to Panama City (PAC-Marcos A. Gelabert Intl.) airport or Balboa (BLB-Panama Pacifico Intl.) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Colon offers. Colon has some interesting things to see and do including Colon 2000 and Colon Free Zone, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Colon?
Sand Diamond Hotel is a luxury hotel with ski-in/ski-out access and a casino, and it's a popular choice for Expedia travelers looking for an elegant place to stay.
When can I expect good weather in Colon?
Planning for the weather is an important factor for making your trip to Colon a success, especially when you're splurging. The hottest months are usually May and September with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in Colon are November, July, August, and October, with each month seeing an average of 14 inches of rainfall.
What's there to see and do in Colon?
Take in the sights and attractions that Colon offers with a visit to Colon 2000, Colon Free Zone, and Gamboa Rainforest Resort. If you have extra time while you're in the area, you might want to see Fantastic Casino | Colón 2000 and Fort San Lorenzo.
How can I get around Colon?
It's easier to get around town in style when you know your options. To see more of the larger area, ride aboard one of the trains from Colon Atlantic Passenger Station.