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Aug 7 - Aug 8
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Our top choices for Cairo hotels

Hotel
Breakfast included
Reserve now, pay later
Pet friendly
Wifi Included

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Sharon
¥10,220
¥11,342 total
includes taxes & fees
Aug 14 - Aug 15
Quality Inn Cairo I-57

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
France
¥9,381
¥10,411 total
includes taxes & fees
Aug 9 - Aug 10
Super 8 by Wyndham Charleston/Sikeston East MO

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Bobby
¥10,536
¥11,693 total
includes taxes & fees
Sep 7 - Sep 8
The Riverstone Hotel Charleston-Sikeston

4. La Center Motel

La Center Motel
La Center
United States
Carrie
¥7,354
¥8,722 total
includes taxes & fees
Sep 7 - Sep 8
La Center Motel

5. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
¥10,925
¥12,125 total
includes taxes & fees
Aug 15 - Aug 16
Eagle Inn Charleston

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
¥23,493
¥45,800 total
includes taxes & fees
Aug 31 - Sep 1
Quiet Country Stay: Modern Home Near Paducah
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

La Center Motel

La Center Motel

8/10 Good
"Decent value. Ice machine was not working."
Jon 2-night trip
Posted 2 days ago
La Center Motel
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent
"Definitely be back and will recommend to my family and friends"
Bobby 1-night trip
Posted 8 days ago
The Riverstone Hotel Charleston-Sikeston
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"Amazing place to stay! 10/10!"
Nicole B. 4-night trip
Posted 10 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

10/10 Excellent
"Great place to stay with our dogs while in town visiting family. We were kept busy by the activities available in the cabin and enjoyed the peace outside. We were tempted to ride the trails, which looked nice, but only didn’t because we opted for mud. High likelihood we will be back. Our dogs were happy and so were we."
Alexia G. 2-night trip
Posted 2 weeks ago
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

10/10 Excellent
"We had a great stay at this cabin. This was a dreamy cabin, cozy, and quiet within beautiful nature. The town was small and cute to enjoy local stuff. The hosts were very nice and friendly and give us really good suggestions to enjoy our stay. Very clean, nicely designed, and accessible. Staying in this cabin is a must if you are in the neighborhood."
Banafsheh B. 1-night trip
Posted 3 weeks ago
Peaceful secluded cabin located near Horseshoe Lake
Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent
"Wonderful hosts with perfect communication all through the vist. Property is large enough for 4 couples, the gazebo with the firepit in the middle is perfect for fires in the other 3 seasons, was too hot to use it this time. Plenty of things to do, with a pool table, dartboard, board games. Yard is large and it's quiet other than road traffic. Decorated well in the hunting/fishing theme. Pets were welcome which is what we were after in trying to get away from an over abundance of fireworks in our area this year. Definitely worth checking out and bringing friends along with you."
AR G. 2-night trip
Posted 1 month ago
Wandering the wineries or hitting the hills? We got you! Come stay!
Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall

10/10 Excellent
"This place is a cozy, charming, clean, close to everything we wanted to see in Paducah place to stay. The neighborhood is quiet and peaceful. The host is very responsive and helpful. I wish we could have stayed longer. We would stay here again."
Vinette M. 2-night trip
Posted 2 months ago
Charming Home just minutes from Interstate and Mall
Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

10/10 Excellent
"This was our second time staying here and we stayed for a full week. Fully enjoyed the time away from home. I did a lot of fishing and my wife did some crafting. Enjoyed a fire down by the lake with roasted hotdogs and s'mores. Grilled for dinner a couple of times also. Other nights we brought pre-prepared meals. It's a great getaway out away from the cities. Be prepared to relaxed and enjoy!"
Paul B. 6-night trip
Posted 2 months ago
Charming cottage overlooking Lake Acre
Welcoming 4-bedroom house with AC in charming La Center

Welcoming 4-bedroom house with AC in charming La Center

10/10 Excellent
"We needed a 1 night stay, got in late. Great house and it was clean. The only comment I would say and they are very minor is, there was no light outside and it was very dark. Also, the rug at the front door both inside and out, had no grip so we slid around a bit."
vickie b. 1-night trip
Posted 2 months ago
Welcoming 4-bedroom house with AC in charming La Center

More cheap stays in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
¥7,354
¥8,722 total
Sep 7 - Sep 8
includes taxes & fees
7.6/10 Good! (21 reviews)
La Center Motel
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
¥9,381
¥10,411 total
Aug 9 - Aug 10
includes taxes & fees
6.6/10 (653 reviews)
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Cairo I-57

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL
¥10,220
¥11,342 total
Aug 14 - Aug 15
includes taxes & fees
6.4/10 (293 reviews)
Quality Inn Cairo I-57
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO
¥10,536
¥11,693 total
Sep 7 - Sep 8
includes taxes & fees
The Riverstone Hotel Charleston-Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
¥10,925
¥12,125 total
Aug 15 - Aug 16
includes taxes & fees
6.6/10 (106 reviews)
Eagle Inn Charleston

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Cairo offers a variety of scenic activities, including national parks and nature preserves perfect for outdoor enthusiasts.
  • Riverboat Tours: Experience the area's natural beauty and history with a unique riverboat tour.
  • Charming Streets: Explore the family-friendly atmosphere and charming streets of Cairo, ideal for leisurely strolls.
  • Rich Historical Experiences: Discover historic forts and sites that showcase Cairo's cultural heritage.
  • Diverse Accommodations: Enjoy a range of lodging options, from cozy inns to modern hotels, accommodating various needs.

Find great hotels in and around Cairo

Explore a variety of hotel accommodations in Cairo, Illinois, where you'll find welcoming options perfect for families, pet owners, and LGBTQIA travelers. From charming motels to comfortable hotels, Cairo offers a range of lodging types to suit your needs. Whether you're looking for a cozy inn or a modern hotel, you can discover the ideal place to unwind during your visit to this unique destination.

  • Super 8 by Wyndham Charleston/Sikeston East MO: Super 8 by Wyndham Charleston/Sikeston East MO offers a comfortable and budget-friendly motel experience just 16km from Cairo. This property is particularly appealing to families and pet owners, featuring amenities designed for children, including complimentary cribs upon request. The pet-friendly policy allows for certain pets onsite, making it a great choice for those who want to travel with their furry companions. Families can enjoy a relaxed stay with the added convenience of amenities that cater to younger guests.
  • The Riverstone Hotel Charleston-Sikeston: Located 19km from Cairo, The Riverstone Hotel Charleston-Sikeston is ideal for business travelers and pet owners alike. This budget-friendly hotel features a welcoming atmosphere that caters to the needs of those traveling for work while also accommodating pets. With a policy that permits dogs and provides necessary deposits, guests can rest easy knowing their pets are welcome. The hotel's blend of comfort and functionality makes it a solid option for those looking to balance business and leisure during their stay.
  • Quality Inn Cairo I-57: Situated in Cairo, the Quality Inn Cairo I-57 provides a family-friendly and budget-conscious lodging option. This hotel caters to travelers with children, offering amenities such as complimentary cribs and a first aid kit for peace of mind. Additionally, the pet-friendly policy ensures that guests can bring their dogs along, with specific fees and deposits in place. This makes it an excellent choice for families and pet owners looking for convenience and comfort during their vacation.

Where to stay near Cairo

Cairo, Illinois, offers a unique blend of outdoor adventures and rich historical experiences. Explore the charming streets of Cairo, where family-friendly vibes abound, or enjoy the scenic beauty at local campgrounds. Nearby cities add to the adventure with vibrant atmospheres perfect for both relaxation and exploration. Whether you're seeking a relaxing holiday or an exciting getaway, Cairo and its surrounding areas promise unforgettable experiences for every traveler.

  • Wickliffe: Located a mere 10km from Cairo, Wickliffe is a charming city that offers a perfect blend of outdoor activities and scenic beauty. Visitors flock here primarily during the spring and late summer months, seeking a romantic getaway amidst nature. With its array of recreational areas and golf courses, Wickliffe is ideal for those who enjoy active pursuits. Don't miss the nearby lake and national state park, which provide excellent opportunities for hiking and picnicking in a picturesque setting.
  • Mound City: Also situated 10km from Cairo, Mound City is an adventure seeker’s paradise. Known for its outdoor and romantic experiences, the city sees a spike in visitors during March, July, and October. The recreational areas and parks are perfect for family outings or a peaceful day in nature. Explore the lush forests and serene lakes in the vicinity, where you can engage in activities like fishing, hiking, and simply enjoying the beautiful landscapes.
  • Wyatt: Just 11km from Cairo, Wyatt caters to families and city enthusiasts alike. The city experiences a busy travel season from June to August, making it a great summer destination. Wyatt features ample outdoor spaces, including golf courses and dog parks, ensuring fun for everyone. Visitors can unwind at local urban parks or attend events at the conference venue, creating a vibrant community atmosphere that invites exploration and relaxation.

Things to do in Cairo

Shopping

In Cairo, visit local shops for unique souvenirs and gifts. If you're up for a drive, head to the nearby Town Center at the Crossings, about 24km away, offering a range of retail options, dining, and entertainment for a more extensive shopping experience.

Recreation

In Cairo, Illinois, the River Wellness Center offers a serene atmosphere with a range of holistic treatments and fitness classes. Nearby, the Shawnee National Forest invites outdoor enthusiasts to explore scenic trails, with opportunities for hiking and meditation amidst nature's beauty.

Adventure

In Cairo, explore the scenic trails of the Mississippi River, ideal for hiking and birdwatching. Visit the confluence of the Ohio and Mississippi Rivers for breathtaking views, and enjoy fishing or kayaking in the nearby waters for a thrilling outdoor experience.

Nightlife

Cairo, Illinois, offers a laid-back nightlife with options like the Riverfront Bar & Grill, where you can enjoy live music and casual dining by the river. The nearby local pubs provide a relaxed atmosphere for drinks and socializing, creating a friendly vibe to unwind after a day of exploring.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in and around Cairo

Cairo, Illinois, is perfect for travelers seeking outdoor adventure and scenic beauty. Popular attractions include national and state parks, nature preserves, and historic forts, offering a rich cultural and natural experience. Whether you're looking to explore the great outdoors or immerse yourself in history, Cairo has something for everyone to enjoy during your vacation.

  • Ballard Wildlife Management Area: Located 8km from Cairo, this reserve offers a serene escape into nature, ideal for birdwatching and exploring diverse habitats. Its historical significance adds a layer of intrigue, making it a peaceful spot for those interested in ecology and history.
  • Columbus-Belmont State Park: Situated 27km away, this state park features stunning scenery and outdoor activities such as hiking and picnicking. The park's rich history from the Civil War era enhances its adventurous atmosphere, perfect for nature lovers and history buffs alike.
  • Fort Defiance State Park: Nestled within Cairo, this historic fort provides a glimpse into the area's cultural heritage. Visitors can enjoy walking trails and scenic views of the confluence of the Mississippi and Ohio Rivers, making it a great place for reflection and exploration.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois is convenient with several nearby airports. Cape Girardeau Municipal Airport (CGI) is situated 42km away, with hotels like Drury Plaza Hotel and Courtyard by Marriott only a short drive from the airport. Paducah Regional Airport (PAH) is located 37km from Cairo, offering nearby accommodations such as The Respite Bed and Breakfast and Harrah's Metropolis Hotel. For those flying into Veterans Airport of Southern Illinois (MWA), 84km away, options include Drury Inn & Suites Marion and Holiday Inn Express & Suites Carbondale. Each airport provides easy access to comfortable lodging for a pleasant stay in Cairo.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best vacation rentals in Cairo?
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This vacation home rental near Cairo is located in a rural location and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 28 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

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