Find hotels in Cairo, IL from ￥10,533

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Dec 23 - Dec 24
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Dec 24 - Dec 25
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Dec 26 - Dec 28
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Our top choices for Cairo hotels

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Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.
"Break fast was excellent "
United States
Uma
The price is ￥11,127
￥12,349 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Quality Inn Cairo I-57
Basic Double Room | Living area
La Center Motel

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17)
Just 15 minutes from Ohio River Valley, this La Center hotel offers convenient amenities including complimentary WiFi and parking. Easy access to Paducah and Barkley Regional Airport makes exploration effortless.
"Quiet and convenient."
United States
Alma
La Center Motel
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
"Staff was great! Room was nice. "
United States
Lana
The price is ￥9,743
￥10,811 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham Charleston/Sikeston East MO
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (104)
Discover relaxation at this Charleston motel offering complimentary WiFi and parking. The onsite health club provides fitness options after exploring local attractions. Cape Girardeau Municipal Airport is just a 43-minute drive away.
"Middle of nowhere hotel was ok"
United States
David
The price is ￥9,491
￥10,533 total
includes taxes & fees
Dec 24 - Dec 25
Eagle Inn Charleston
House (2 Bedrooms) | Interior
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ￥18,985
￥45,496 total
includes taxes & fees
Dec 27 - Dec 28
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"The cabin was great"
Kevin G. 2-night trip
Posted 3 weeks ago
Cozy cabins on beautiful Horseshoe Lake

More cheap stays in Cairo

Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
The price is ￥9,491 per night from Dec 24 to Dec 25
￥9,491
￥10,533 total
Dec 24 - Dec 25
includes taxes & fees
6.6/10 (104 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and Quality Inn Charleston - Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best vacation rentals in Cairo?
Quiet Country Stay: Modern Home Near Paducah: This vacation home rental near Cairo offers a garden, a selection of games, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 25 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.