Find 5 Star Hotels in Cairo, IL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Cairo 5 Star Hotels

Save an average of 15% on thousands of hotels when you're signed in

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Cairo?
The amount you pay for a 5-star hotel in Cairo can vary according to the time of year you travel and how long you plan to be away, among a number of factors. Take advantage of our price per night filter and other search tools to land the best rate on a plush stay.

  • Search for the lowest price per night

What makes a hotel 5 stars in Cairo?
Impeccable guest service characterizes every 5-star hotel in Cairo. From the instant you arrive, staff are at your beck and call, whether offering luggage assistance and storage or providing a nightly turn-down service. In addition, hotels must offer superior conveniences to obtain a 5-star rating. These can include luxury bath products, on-site spa facilities, pools, gourmet kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Cairo?
Find a luxury escape that includes your room, meals, drinks and entertainment in Cairo with Expedia's filters. Search for resorts with a 5-star rating and select the "All inclusive" filter. Be sure to check what's included in the purchase price. That way, you're ready to take advantage of all the premium perks from the moment you step into the lobby.