The Best Hotels Closest to Fort Defiance State Park in Cairo for 2026

Our top choices for Fort Defiance State Park hotels

1. La Center Motel

17.5 km from Fort Defiance State Park

Carrie

￥10,266 total

includes taxes & fees

Jul 24 - Jul 25

2. The Riverstone Hotel Charleston-Sikeston

20.2 km from Fort Defiance State Park

Emily

￥12,848 total

includes taxes & fees

Aug 2 - Aug 3

3. Quality Inn Cairo I-57

7.8 km from Fort Defiance State Park

Susan

￥11,763 total

includes taxes & fees

Aug 14 - Aug 15

Laptop workspace, blackout drapes, cribs (free), WiFi (free)

4. Super 8 by Wyndham Charleston/Sikeston East MO

17.5 km from Fort Defiance State Park

Karl

￥10,777 total

includes taxes & fees

Jul 26 - Jul 27

Room, 1 King Bed, Non Smoking | View from room

5. Eagle Inn Charleston

16.2 km from Fort Defiance State Park

Jackson

￥12,497 total

includes taxes & fees

Aug 3 - Aug 4

View all properties

Compare popular hotels close to Fort Defiance State Park

Property	Star rating	Guest rating
La Center Motel	2.0 star property	7.4 Good 20 reviews	View
The Riverstone Hotel Charleston-Sikeston	2.5 star property	6.8 421 reviews	View
Quality Inn Cairo I-57	2.5 star property	6.4 291 reviews	View
Super 8 by Wyndham Charleston/Sikeston East MO	2.0 star property	6.6 648 reviews	View
Eagle Inn Charleston	2.0 star property	6.6 106 reviews	View

Top Fort Defiance State Park Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"It was all good."

Peaceful secluded cabin located near Horseshoe Lake

10/10 Excellent

"We had a great stay at this cabin. This was a dreamy cabin, cozy, and quiet within beautiful nature. The town was small and cute to enjoy local stuff. The hosts were very nice and friendly and give us really good suggestions to enjoy our stay. Very clean, nicely designed, and accessible. Staying in this cabin is a must if you are in the neighborhood."

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent

"We had a freak storm hit and knocked out the power. The generator ran smoothly and the host cleaned up the property quickly. The property was immaculate and suited all our needs. 10 out of 10."

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent

"Wonderful hosts with perfect communication all through the vist. Property is large enough for 4 couples, the gazebo with the firepit in the middle is perfect for fires in the other 3 seasons, was too hot to use it this time. Plenty of things to do, with a pool table, dartboard, board games. Yard is large and it's quiet other than road traffic. Decorated well in the hunting/fishing theme. Pets were welcome which is what we were after in trying to get away from an over abundance of fireworks in our area this year. Definitely worth checking out and bringing friends along with you."

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was relaxing and welcoming. I would definitely stay here again and highly recommend this hotel to anyone looking for a comfortable and enjoyable experience."

Hotels near other Fort Defiance State Park attractions

Columbus-Belmont State Park

7.4/10 (23 reviews)

You can learn about the history of Columbus with a stop at Columbus-Belmont State Park.

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Frequently asked questions

What's the area like around Fort Defiance State Park?

Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.

What's the best place to stay close to Fort Defiance State Park?

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.8 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston.

If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Fort Defiance State Park.

Where can I learn more about changing or cancelling my trip in the area near Fort Defiance State Park?

For more information about updating your stay near Fort Defiance State Park or cancelling it, head over to our customer service page.

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Our top choices for Fort Defiance State Park hotels

1. La Center Motel

2. The Riverstone Hotel Charleston-Sikeston

3. Quality Inn Cairo I-57

4. Super 8 by Wyndham Charleston/Sikeston East MO

5. Eagle Inn Charleston

Compare popular hotels close to Fort Defiance State Park

Top Fort Defiance State Park Hotel Reviews

Drury Inn & Suites Sikeston, MO

Peaceful secluded cabin located near Horseshoe Lake

The Riverstone Hotel Charleston-Sikeston

Country Yard Inn and Suite

Cozy cabin with pond

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Wandering the wineries or hitting the hills? We got you! Come stay!

Days Inn and Suites by Wyndham Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Hotels near other Fort Defiance State Park attractions

Columbus-Belmont State Park

Ullin City Hall

Limekin Springs Trail Trailhead

Front Street Studio & Art Gallery

Lower Cache River Access Area

City of Miner Convention Center

Henry N Barkhausen Cache River Wetlands Center

Frequently asked questions

Find hotels near Fort Defiance State Park, Cairo from ￥10,266

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Fort Defiance State Park hotels

1. La Center Motel

2. The Riverstone Hotel Charleston-Sikeston

3. Quality Inn Cairo I-57

4. Super 8 by Wyndham Charleston/Sikeston East MO

5. Eagle Inn Charleston

Compare popular hotels close to Fort Defiance State Park

Top Fort Defiance State Park Hotel Reviews

Drury Inn & Suites Sikeston, MO

Hotels near other Fort Defiance State Park attractions

Columbus-Belmont State Park

Frequently asked questions