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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

9.8/10 Exceptional! (518 reviews)

"A beautiful, historic bed & breakfast right in the heart of Winona and close to downtown. This is an incredible house and restoration effort. Old radios in almost every room, in incredible details, and one of the kindest hosts I’ve met. Learned a lot about the history of the building when I arrived ..."

Reviewed on Jun 23, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,000 reviews)

Couples like: full-service spa, bar

Travelers say...

"Nice"

Reviewed on Jun 21, 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (758 reviews)

"Clean, updated, good clean breakfast area, attentive and friendly staff"

Reviewed on Jun 25, 2026

See all 1,188 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.