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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

10/10 Exceptional! (364 reviews)

Yes

Reviewed on Dec 8, 2025

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,002 reviews)

Couples like: full-service spa, bar

Travelers say...

Lovely room, great restaurant on site, free parking, nice staff.

Reviewed on Dec 7, 2025

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.6/10 Excellent! (716 reviews)

Yes

Reviewed on Nov 30, 2025

See all 1,196 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.