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Top Romantic Southern Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

9.8/10 Exceptional! (503 reviews)

Excellent breakfast and the host accommodated dietary needs.

Reviewed on May 10, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,004 reviews)

Couples like: full-service spa, bar

Travelers say...

Our sink didn't drain The shower didn't drain but the stopper didn't work, the cold water kept coming out of shower, so it didn't work to shower or take a bath

Reviewed on May 2, 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (743 reviews)

I would have given a 5 star except that the towels were stained . So didnt feel clean sink wasnt cleaned either under the rim so looks moldy

Reviewed on May 10, 2026

See all 1,205 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.