Photo by Southernmost Illinois Tourism Bureau

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Pet-friendly Southern Illinois Hotels

La Quinta Inn & Suites by Wyndham Effingham

1103 Avenue Of Mid America Effingham IL

4 hours drive from Shawnee National Forest

This pet-friendly hotel welcomes dogs and cats (fees apply).

9.2/10 Wonderful! (1,004 reviews)

"Everything was clean and new. We arrived late and left early, so we did not spend much time there, but it was a pleasant stay"

Reviewed on Jun 30, 2026

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

4 hours drive from Shawnee National Forest

This pet-friendly hotel welcomes dogs and cats (fees apply).

5.8/10 (1,001 reviews)

"It was dated it felt dirty, our drawer with the television on top had a collapsed, broken splinter side I wouldn’t ever stay there again"

Reviewed on Jun 25, 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

4 hours drive from Shawnee National Forest

Make it a pet-friendly trip and bring along your four-legged friend. Dogs and cats are welcome (fees apply) at this city-center hotel.

7.8/10 Good! (1,002 reviews)

"We stay here every time we are in town. The place is always clean, and the staff is very helpful and kind."

Reviewed on Jun 29, 2026

See all 1,143 properties in Southern Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.