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Top Luxury North Central Florida Hotels

Baymont By Wyndham Gainesville I-75

6901 NW 4th Boulevard Gainesville FL

21 min walk from University of Florida

Baymont By Wyndham Gainesville I-75 awaits for a deluxe vacation.

Palms Garden Inn

14113 S. US Hwy 441 Lake City FL

58 min drive from University of Florida

Discover luxurious lodging at Palms Garden Inn, where you can enjoy amenities like plush bedding, premium channels, and more.

7.6/10 Good! (626 reviews)

"Host was so kind and polite. I got the exact room I reserved, which hasn’t always happened for me. I’d stay there again and again."

Reviewed on Jun 19, 2026

Americas Best Value Inn Lake City

3835 West US Highway 90 Lake City FL

1 hour drive from University of Florida

Choose luxury at Americas Best Value Inn Lake City, where you can enjoy amenities like premium channels, flat-screen TVs, and more. The outdoor pool and pool ...

8.6/10 Excellent! (1,001 reviews)

"I stay here quite a bit and it’s always clean and friendly and I love it! Also the price is great!"

Reviewed on Jun 21, 2026

See all 2,713 properties in North Central Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.