North Central Florida Luxury Vacations 2026

Photo by Jeff Scott

Plan, book, travel with confidence
Better together
Save up to ￥109,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Luxury North Central Florida Hotels

Baymont By Wyndham Gainesville I-75

6901 NW 4th Boulevard Gainesville FL

21 min walk from University of Florida

Baymont By Wyndham Gainesville I-75 awaits for a deluxe vacation.

5.2/10 (1,003 reviews)

"No hot water just lukewarm water and the place was nasty and run down."

Reviewed on Oct 1, 2026

Palms Garden Inn

14113 S. US Hwy 441 Lake City FL

58 min drive from University of Florida

Discover luxurious lodging at Palms Garden Inn, where you can enjoy amenities like plush bedding, premium channels, and more.

7.6/10 Good! (648 reviews)

"A bit dated, but sufficient for an overnight rest. I wouldn’t recommend it longer than that"

Reviewed on Sep 28, 2026

Americas Best Value Inn Lake City

3835 West US Highway 90 Lake City FL

1 hour drive from University of Florida

Choose luxury at Americas Best Value Inn Lake City, where you can enjoy amenities like premium channels, flat-screen TVs, and more. The outdoor pool and pool ...

See all 2,817 properties in North Central Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.