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Top Luxury Mesopotamia Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR

17 hours drive from Termas de Federacion

Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...

9.8/10 Exceptional! (1,006 reviews)

We loved this hotel and its access to the falls. We took a dawn hike at 5am and had the park to ourselves. This was the highlight of our trip to Brazil.

Reviewed on Dec 7, 2025

Iguazu Grand Resort Spa & Casino

Route 12 Km 1640 Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Pamper yourself with a luxury stay at Iguazu Grand Resort Spa & Casino, where you can enjoy amenities like Champagne service, massage services, and more. The ...

9/10 Wonderful! (585 reviews)

Clean room; Friendly staff; Need some improvement on decorations; Great amenities; A little far from main downtown for anyone wanting to be next to the action.

Reviewed on Nov 21, 2025

Gran Melia Iguazú

Parque Nacional Iguazu Puerto Iguazú Misiones

17 hours drive from Termas de Federacion

Go for a luxurious stay at Gran Melia Iguazú, where you can enjoy amenities like massage services, Egyptian cotton sheets, and more. Deluxe amenities at this ...

9.2/10 Wonderful! (1,002 reviews)

Amazing hotel

Reviewed on Dec 4, 2025

See all 490 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.