Southern Minnesota Luxury Vacations 2026

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Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,324 reviews)

"Old feel. Still going through renovations and more needs to be done to meet current market standards"

Reviewed on Sep 24, 2026

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Go for a luxurious stay at AmericInn by Wyndham Blue Earth, where you can enjoy amenities like 24-hour room service, premium channels, and more.

7.8/10 Good! (516 reviews)

"Our room smelled musty. There was no elevator. We both got some kind of bug bites. It was not clean"

Reviewed on Sep 21, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

7.8/10 Good! (1,018 reviews)

"Rooms were clean and the room temperature was comfortable. We did not spendmuch time there, as we were at Mayo Clinics most of the time."

Reviewed on Sep 24, 2026

See all 1,230 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.