
Eastern South Dakota Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
Photo by Jenna Stokes
- Plan, book, travel with confidence
Better together
Save up to ¥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top Luxury Eastern South Dakota Hotels

Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport
3101 W Russell St, Sioux Falls, SD
Be treated to luxurious accommodations at Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport, where you can enjoy amenities like hydromassage showers, ...
6.6/10 (1,010 reviews)
"An easy, off the interstate hotel, great for stopping to get a few hours sleep while traveling. Has lots of dated and broken odds and ends. But the staff (both the night and early morning) are friendly and helpful and professional."
Reviewed on Sep 19, 2025

Econo Lodge Sioux Falls Empire Mall
3500 Gateway Boulevard, Sioux Falls, SD
Stay in the lap of luxury at Econo Lodge Sioux Falls Empire Mall, where you can enjoy amenities like premium channels, flat-screen TVs, and more.
Economy hotel, no thrills, but it's nice
"Staff was really nice. Rooms are spacious. Good value and convenient to many stores/restaurants, etc. Rooms for clean."
Reviewed on Oct 18, 2022

My Place Hotel - Sioux Falls, SD
3005 S. Carolyn Ave, Sioux Falls, SD
Go for a luxurious stay at My Place Hotel - Sioux Falls, SD, where you can enjoy amenities like pillowtop beds, premium channels, and more.
8.4/10 Very Good! (1,011 reviews)
"We didn’t arrive until about 2am due to traveling and the lady at the desk was very nice and helpful. It was overall very clean and accommodating as we had our dog with us. I didn’t care for the beds much, but my husband did, may just not be what I’m used to. Overall a very nice stay, would stay ..."
Reviewed on Sep 25, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.