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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.

5.8/10 (885 reviews)

"Room was not clean. Used soap bars in shower. Room was just nasty although heard from other people there rooms were nice. So evidently we had one that had not been renovated. The refrigerator did not work warmer inside than room and tried adjusting nothing. The sink had been painted and was peeling. ..."

Reviewed on Oct 25, 2026

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.

See all 704 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.