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Top Luxury Southeast Missouri Hotels

Super 8 by Wyndham Pevely

1711 Highway Z Pevely MO

3 hours drive from Mark Twain National Forest

Super 8 by Wyndham Pevely awaits for a deluxe vacation. Popular amenities include an indoor pool, a fitness center, and pool loungers.

5.6/10 (863 reviews)

"The room was clean and the bed was comfortable. The staff was very helpful"

Reviewed on Aug 5, 2026

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Motel 6 Poplar Bluff, MO awaits for a deluxe vacation.

8/10 Very Good! (1,009 reviews)

"Staff unhelpful, not polite at check in, uncomfortable bed, sticky floor, room smelled of urine, no tv remote and when desk was asked for a remote she said that room didn’t have one. No hot water, apparently they had a gas leak so no hot water but this wasn’t told by staff. No charging stations."

Reviewed on Aug 5, 2026

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

4 hours drive from Mark Twain National Forest

Days Inn and Suites by Wyndham Sikeston awaits for a deluxe vacation.

See all 681 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.