South America Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
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Top Luxury vacation packages in South America
Price found within the past 48 hours. Click for updated prices.
Palacio Duhau - Park Hyatt Buenos Aires
Recoleta
￥166,036
per person
Oct 9 - Oct 11
found 24 hours ago
Roundtrip flight included
Sao Paulo (SAO) to Buenos Aires (EZE)
9.4/10 Exceptional! (518 reviews)
Excelente hotel. Suite Park vale a estadia
Café da manhã muito bom. Localização perfeita.
Lindo jardim.
Reviewed on Jul 4, 2026
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View all trips5* Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
Palacio Duhau - Park Hyatt Buenos Aires
Recoleta
￥166,036
per person
Oct 9 - Oct 11
found 24 hours ago
Roundtrip flight included
Sao Paulo (SAO) to Buenos Aires (EZE)
9.4/10 Exceptional! (518 reviews)
Excelente hotel. Suite Park vale a estadia
Café da manhã muito bom. Localização perfeita.
Lindo jardim.
Reviewed on Jul 4, 2026
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See all available trips from Sao Paulo to South America
View all trips4 Night Luxury vacations in South America
Price found within the past 48 hours. Click for updated prices.
Monasterio, A Belmond Hotel, Cusco
Cusco Historic Center
￥289,796
per person
Oct 30 - Nov 2
found 1 day ago
Roundtrip non-stop flight included
Mexico City (MEX) to Cusco (CUZ)
9.8/10 Exceptional! (512 reviews)
Desayuno y Cena maravillosos. Su cedro blanco andino de 350 años es la estrella del hotel. Súper recomendado. Lo califico como el mejor hotel que he estado en el mundo. .
Reviewed on Jul 26, 2026
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View all tripsTop Luxury South America Hotels
Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Rodovia Br 469 Km 32 Foz do Iguaçu PR
￥112,724
￥130,483 total
Sep 9 - Sep 10
includes taxes & fees
Treat yourself to a luxury stay at Hotel das Cataratas, A Belmond Hotel, Iguassu Falls, where you can enjoy amenities like 24-hour room service, free stocked ...
10/10 Exceptional! (1,005 reviews)
"Amazing stay"
Reviewed on Sep 3, 2026
Hotel Club Frances
Rodríguez Peña 1832 Buenos Aires Capital Federal
￥34,427
￥34,896 total
Sep 12 - Sep 13
Hotel Club Frances is one of the Buenos Aires sumptuous 5-star boutique properties where you can pamper yourself with deep soaking bathtubs and massage services. ...
Palacio del Inka, A Luxury Collection Hotel by Marriott
Plazoleta Santo Domingo No 259 Cusco Cusco
￥49,011
￥60,378 total
Oct 4 - Oct 5
Go for a luxurious stay at Palacio del Inka, A Luxury Collection Hotel by Marriott, where you can enjoy amenities like Champagne service, pillowtop beds, and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
