
Panama Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
Photo by PhotoJoy
- Plan, book, travel with confidence
Better together
Save up to ¥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top Luxury Panama Hotels

JW Marriott Panama
Calle Punta Colon, Punta Pacifica, Panama City, Panama
The price is ¥29,782 per night from Aug 1 to Aug 2
¥29,782
¥32,760 total
Aug 1 - Aug 2
includes taxes & fees
Be treated to luxurious accommodations at JW Marriott Panama, where you can enjoy amenities like massage services, 24-hour room service, and more. The 4 outdoor ...
8.8/10 Excellent! (1,004 reviews)
JW Marriott Experience
"The hotel was spotless, and the staff were friendly. It's a bit expensive, as I was expecting more of a luxury hotel. The only bad thing was the breakfast one morning, when everything was cold and the cup of coffee wasn't hot. The toast was hard as a rock, so it was a total disappointment for the ..."
Reviewed on Jul 18, 2025

Bristol Panama, a Registry Collection Hotel
Avenida Aquilino de La Guardia, Bella Vista, Panama City, Panama
The price is ¥27,814 per night from Aug 3 to Aug 4
¥27,814
¥30,595 total
Aug 3 - Aug 4
includes taxes & fees
Treat yourself to some sumptuous lodging at Bristol Panama, a Registry Collection Hotel, where you'll find deep soaking bathtubs and pillowtop beds. Notable ...
9.2/10 Wonderful! (1,002 reviews)
"I love the staff! Leonardo is the perfect host."
Reviewed on Jul 17, 2025

Waldorf Astoria Panama
47th St. & Uruguay Street, Panama City, Panama
The price is ¥31,534 per night from Aug 8 to Aug 9
¥31,534
¥34,687 total
Aug 8 - Aug 9
includes taxes & fees
Pamper yourself with a luxury stay at Waldorf Astoria Panama, where you can enjoy amenities like Champagne service, 24-hour room service, and more. The 2 bars, ...
8.8/10 Excellent! (1,002 reviews)
"Absolutely amazing from check in to check out."
Reviewed on Jul 17, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.