Photo by Southernmost Illinois Tourism Bureau

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Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane Whittington IL

1 hour drive from Southern Illinois University

Book a stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.8/10 Excellent! (900 reviews)

Everything was great.

Reviewed on Nov 29, 2025

Hampton Inn Carbondale

2175 Reed Station Pkwy Carbondale IL

10 min drive from Southern Illinois University

Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.2/10 Very Good! (611 reviews)

Nice hotel

Reviewed on Nov 28, 2025

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive Caseyville IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cahokia Mounds State Historic ...

3.8/10 (331 reviews)

Yes

Reviewed on Nov 2, 2025

See all 729 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.