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Top Luxury Southern Minnesota Hotels

Kahler Grand Hotel

20 2nd Ave Sw Rochester MN

2 min walk from Mayo Clinic

Kahler Grand Hotel offers luxe lodging where you'll enjoy premium bedding and more. Deluxe amenities at this hotel include an indoor pool, a 24-hour fitness ...

8.4/10 Very Good! (2,153 reviews)

"Noise exterior and interior"

Reviewed on Jun 19, 2026

AmericInn by Wyndham Blue Earth

1495 Domes Dr Blue Earth MN

5 hours drive from Mayo Clinic

Go for a luxurious stay at AmericInn by Wyndham Blue Earth, where you can enjoy amenities like 24-hour room service, premium channels, and more. Deluxe amenities ...

7.8/10 Good! (492 reviews)

"You could never find some someone to help you the didn’t have. Hot tub like they said they do pool was not very clean. No towels."

Reviewed on Jun 9, 2026

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Indulge yourself with upscale accommodations at Med City Inn & Suites - Mayo Clinic Area, where you'll enjoy amenities like premium channels and more. Notable ...

8/10 Very Good! (1,001 reviews)

"Breakfast was subpar. No waffle mix, milk for cereal and pancake grill didn’t even work. Hallway was musty. Location was great for access to Mayo and a walking trail close by."

Reviewed on Jun 17, 2026

See all 1,186 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.