Upstate South Carolina Luxury Vacations

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Top Luxury Upstate South Carolina Hotels

The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St, Greenville, SC
  • 1 hour drive from Clemson University
Go for a luxurious stay at The Westin Poinsett Greenville, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Notable amenities ...
9.2/10 Wonderful! (1,006 reviews)
"We visited Greenville for a wedding and our stay at the Westin was perfect!"

Reviewed on Sep 12, 2025

The Westin Poinsett Greenville
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St, Greenville, SC
  • 1 hour drive from Clemson University
Stay in the lap of luxury at Hyatt Regency Greenville, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. Deluxe amenities at ...
8.6/10 Excellent! (1,015 reviews)
"Nice easy walk to bon seCour center"

Reviewed on Sep 24, 2025

Hyatt Regency Greenville
Sleep Inn at Greenville Convention Cente

Sleep Inn at Greenville Convention Cente

2.5 out of 5
231 N Pleasantburg Dr, Greenville, SC
  • 1 hour drive from Clemson University
Indulge in a luxury vacation at Sleep Inn at Greenville Convention Cente. Notable amenities at this hotel include a fitness center and an area shuttle.
7.8/10 Good! (1,006 reviews)
"Great stay at the Sleep Inn Greenville Convention Center! Staff were professional and polite, the manager was friendly and checked in on our visit, and parking was easy. Helpful team all around—highly recommend!"

Reviewed on Sep 21, 2025

Sleep Inn at Greenville Convention Cente
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.