Photo by Visit Greenville, South Carolina

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Top Beach Upstate South Carolina Hotels

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks

Seneca SC

21 min drive from Clemson University

Lounge by the shoreline in Seneca, as you'll be a short walk from the beach when booking a getaway at this vacation home. Beach towels and sun loungers are just ...

10/10 Exceptional! (198 reviews)

Travelers like: on the beach, sun loungers, beach towels, pool

Travelers say...

Amazing home.....generous host

Reviewed on Nov 9, 2025

Quality Inn Clinton - Laurens I-26

105 Trade St Clinton SC

3 hours drive from Clemson University

Book a stay at this business-friendly hotel in Clinton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

7.2/10 Good! (499 reviews)

Was a very nice hotel. Very clean and the room was spacious.

Reviewed on Nov 14, 2025

Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

801 Spartan Blvd Spartanburg SC

2 hours drive from Clemson University

Stay at this hotel in Spartanburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.6/10 Excellent! (968 reviews)

Room was spotless, staff was very friendly.

Reviewed on Nov 6, 2025

See all 2,891 properties in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.