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Our top choices for Southern Minnesota hotels

An indoor swimming pool with a curved design, surrounded by palm trees and a white pool ladder.

1. Treasure Island Resort & Casino

Welch

Kristine

￥16,175 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel lobby with a dining area, seating arrangements, and a stone fireplace.

2. Fairfield Inn & Suites by Marriott Winona

Winona

Leanne

￥23,616 total

includes taxes & fees

Nov 1 - Nov 2

A modern dining area with high tables, chairs, and pendant lighting.

3. Hampton Inn & Suites Rochester-North

Rochester

Mark

￥18,618 total

includes taxes & fees

Nov 6 - Nov 7

A swimming pool with a tiled edge, a lifeguard stand, and a seating area with chairs and tables.

4. Holiday Inn Express Hotel and Suites Mankato East by IHG

Mankato

Dale

￥16,270 total

includes taxes & fees

Nov 22 - Nov 23

A hotel lobby with a reception desk, a coffee station, and a seating area with tables and chairs.

5. AmericInn by Wyndham Mankato Event Center

Mankato

Brian

￥13,827 total

includes taxes & fees

Nov 22 - Nov 23

A courtyard with rows of white chairs and tables, a pool, and a Marriott hotel building in the background.

6. Courtyard Mankato Marriott

Mankato

Ellen

￥18,733 total

includes taxes & fees

Nov 22 - Nov 23

A hotel with outdoor seating and a fire pit.

7. Country Inn & Suites by Radisson, Mankato Hotel and Conference Center, MN

Mankato

Bridget

￥17,100 total

includes taxes & fees

Nov 22 - Nov 23

A Comfort Inn & Suites building with a covered entrance, numbered 2000, and a parking lot with cars.

8. Comfort Inn & Suites North Mankato

Mankato

Cara

￥15,653 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

9. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Arlan

￥21,433 total

includes taxes & fees

Nov 27 - Nov 28

An indoor swimming pool with lounge chairs and a sunbed, surrounded by walls with patterned tiles.

10. AmericInn By Wyndham Mountain Lake Mn

Mountain Lake

Misty

￥21,956 total

includes taxes & fees

Nov 4 - Nov 5

A hotel with a stone facade, multiple windows, and a covered entrance.

11. Cobblestone Hotel & Suites - Austin

Austin

Pamela

￥18,735 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio area with a concrete floor, wooden fence, and string lights.

12. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

Brien

￥21,087 total

includes taxes & fees

Nov 6 - Nov 7

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

13. Hampton Inn Rochester-South

Rochester

Susan

￥17,754 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a reception desk, seating area, and artwork on the walls.

14. Holiday Inn Express & Suites Worthington by IHG

Worthington

Kirsten

￥17,668 total

includes taxes & fees

Nov 29 - Nov 30

A spacious living room with a stone fireplace, large windows with a view, and comfortable seating.

15. AmericInn by Wyndham Lake City

Lake City

Benny

￥18,500 total

includes taxes & fees

Nov 29 - Nov 30

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

16. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

howard

￥19,917 total

includes taxes & fees

Nov 29 - Nov 30

An outdoor patio area with a fire pit, seating, and a pergola.

17. Country Inn & Suites by Radisson, Albert Lea - Austin

Albert Lea

Gail

￥14,099 total

includes taxes & fees

Nov 22 - Nov 23

A spacious indoor pool area with multiple levels, a hot tub, and a seating area with tables and chairs.

18. Best Western Plus New Ulm

New Ulm

Betsy

￥20,815 total

includes taxes & fees

Nov 11 - Nov 12

A modern kitchen with a central island, wooden cabinets, and pendant lighting.

19. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

Cory

￥24,883 total

includes taxes & fees

Nov 6 - Nov 7

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park

Jackie

￥20,269 total

includes taxes & fees

Nov 22 - Nov 23

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Vacation Rentals in Southern Minnesota

Aparthotel

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

The Berkman

Folwell

"Excellent service and wonderful room!"

Apartment

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester

"Clean room and great location"

Apartment

A wooden interior with a kitchen, bar area, and a staircase.

Lake Pepin Escape: Loft Cottage & Fireplace

Pepin

"Great location and very well furnished with new appliances."

Apartment

A modern kitchen with a central island, bar stools, and a large window.

1 Block to Lake City Marina: Condo w/ Rooftop Deck

Lake City

"Wonderful property, spacious, well-appointed and comfortable. Would definitely rent again."

Apartment

A bedroom with a bed, a chair, a table, a fireplace, and a ceiling fan.

Pet-friendly Wabasha Studio: Boat, Ski & Explore!

Wabasha

"Great property! Very convenient location as well."

Cottage

A modern interior with a stone fireplace, wooden walls, a leather sofa, and a dining area.

Pet-friendly Cabin Retreat: Walk to Lake Pepin!

Pepin

"What a fun place! Plenty of room. We played foosball had a fire outside. We enjoyed the fireplace too. We hadn’t anticipated no TV though. You might want to add that to your description. The water is definitely smelly, so we truly appreciated the 40 bottles of water you provided. Definitely a great place for a girl’s weekend or family reunion!"

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Stay near popular Southern Minnesota attractions

Mayo Civic Center

9.2/10 (818 reviews)

Catch an event at Mayo Civic Center during your trip to Rochester. Attend a sporting event or simply visit the area's shops.

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Learn more about Southern Minnesota

Discover the family-friendly area of Southern Minnesota—an opera house, a college vibe, and sights from Mount Kato Ski Area to Blakeslee Stadium.

See all hotels in Southern Minnesota

A lake surrounded by dense forest and a distant hill with a fort.

Top Southern Minnesota Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Was a quick and comfortable stay."

AmericInn by Wyndham Mankato Event Center

10/10 Excellent

"Beautiful Clean Room with Friendly Staff--So Nice! The parking was simple, well lit and safe. Breakfast was wonderful with plenty of options to choose from and the coffee flowed freely! Had a perfect stay at AmericInn by Wyndham Mankato Event Center! Would absolutely recommend staying here!"

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"Staff was extremely helpful and friendly. Breakfast was definitely above average and our room was clean and in good condition. All connected to pedestrian subway to all Mayo buildings, parking ramps and shopping. I’ll be going back to Mayo for future appointments and will definitely book the Kahler Inn and Suites again."