Find Business Hotels in Southern Indiana

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Check availability on Southern Indiana Business Hotels

Tonight
Dec 3 - Dec 4
Tomorrow
Dec 4 - Dec 5
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Top Southern Indiana Business Hotels

Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1698)
"Wonderful property and staff. Would love to stay again. "
United States
Hanna
The price is ￥26,011
￥30,605 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Omni Louisville Hotel
Breakfast, lunch and dinner served
Hyatt Regency Louisville

Hyatt Regency Louisville

4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1001)
"Enjoyed our stay "
United States
Jedediah
The price is ￥18,045
￥21,231 total
includes taxes & fees
Dec 18 - Dec 19
Hyatt Regency Louisville
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1000)
" Loved our stay, would definitely plan to come back if we are ever in the area again."
United States
Erica
The price is ￥21,623
￥26,222 total
includes taxes & fees
Jan 1 - Jan 2, 2026
21c Museum Hotel Louisville
Exterior
Garner Hotel Evansville East by IHG

Garner Hotel Evansville East by IHG

3.0 star property
Evansville
8.8 out of 10, Excellent, (75)
"Peaceful place to stay."
United States
Deborah
The price is ￥11,698
￥13,452 total
includes taxes & fees
Dec 7 - Dec 8
Garner Hotel Evansville East by IHG
Water park
Fairfield Inn By Marriott Evansville East

Fairfield Inn By Marriott Evansville East

2.5 star property
Evansville
8.8 out of 10, Excellent, (457)
"Clean rooms friendly staff "
United States
Aleshia
The price is ￥13,090
￥15,054 total
includes taxes & fees
Dec 14 - Dec 15
Fairfield Inn By Marriott Evansville East
Lobby
Hampton Inn Evansville/Airport

Hampton Inn Evansville/Airport

2.5 star property
Evansville
9.2 out of 10, Wonderful, (547)
"Great beds, nice breakfast"
United States
Sue
The price is ￥13,565
￥15,600 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hampton Inn Evansville/Airport
Exterior
Holiday Inn Express & Suites Evansville North by IHG

Holiday Inn Express & Suites Evansville North by IHG

2.5 star property
Evansville
8.6 out of 10, Excellent, (578)
"Very clean and friendly place"
Canada
Sarah
The price is ￥12,960
￥14,904 total
includes taxes & fees
Dec 12 - Dec 13
Holiday Inn Express & Suites Evansville North by IHG
Lobby
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1001)
"Room looked very nice when we checked in"
United States
Todd
The price is ￥19,701
￥23,180 total
includes taxes & fees
Dec 26 - Dec 27
Seelbach Hilton Louisville Downtown
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (427)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is ￥26,313
￥30,960 total
includes taxes & fees
Dec 27 - Dec 28
Hotel Distil, Autograph Collection
Free continental breakfast
Knights Inn and Suites Salem

Knights Inn and Suites Salem

3.0 star property
Salem
8.4 out of 10, Very Good, (346)
"Welcoming staff, clean room, quiet stay. Would recommend. Great value for price. "
United States
Jennifer
The price is ￥11,200
￥12,700 total
includes taxes & fees
Dec 29 - Dec 30
Knights Inn and Suites Salem
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Indiana Hotel Reviews

La Quinta Inn & Suites by Wyndham Evansville

La Quinta Inn & Suites by Wyndham Evansville

10/10 Excellent
"The room was beautiful, very clean, smelled amazing, and was very quiet! I will absolutely be staying here again!"
Lisa 1-night trip
Posted 1 day ago
La Quinta Inn & Suites by Wyndham Evansville

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Frequently asked questions

How much do business-friendly hotels in Southern Indiana cost?
Business-friendly hotels in Southern Indiana range between ￥13,452 and ￥30,960 per night. This means you can book a property with welcome amenities like workspaces and conference rooms at a price that fits your work budget. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southern Indiana?
Southern Indiana offers multiple business-friendly hotels with a total average guest review rating of 8.8. Have a work event in Louisville? Residence Inn by Marriott Louisville East/Oxmoor is a 3-stars stay that's highly recommended by corporate travelers and features a barbecue grill and a swimming pool. Another popular pick for a business trip is Hilton Garden Inn Louisville Mall of St. Matthews. Also in Louisville, it has a 3-stars rating and conveniences such as an electric car charging station and a terrace.
How many business-friendly hotels are there in Southern Indiana?
When your next meeting or conference takes you someplace in Southern Indiana, you'll have 132 business-friendly hotels to pick from.
What are the best cheap business-friendly hotels in Southern Indiana?
When work is taking you out of town in Southern Indiana, Expedia will help you find the perfect business-friendly hotel. Holiday Inn Express & Suites Louisville Downtown, an IHG Hotel is a sought-after budget option in Louisville. Hypo-allergenic bedding and an electric car charging station are among its many amenities. Seeking affordable stays in Evansville? Hampton Inn Evansville/Airport is the first choice for many corporate guests. It has conveniences that make it easy to both work and feel at home, such as pillow top mattresses and a swimming pool. Business-friendly hotels in Southern Indiana start at only ￥13,452 a night. There are tons of fabulous and free things to do wherever you're visiting in Southern Indiana. If your business trip is taking you to Louisville, try to find time in your schedule for Louisville Waterfront Park. You can also see the sights without spending a penny in Evansville. Bally's Evansville Casino is a popular free thing to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in Southern Indiana?
Welcoming and affordable, motels are an ideal choice for your next business trip in Southern Indiana. If your job is taking you to Louisville, check out Days Inn by Wyndham Louisville Airport Fair and Expo Center. It's around 11 kilometers south of the downtown area and includes amenities like individually decorated rooms and WiFi. Super 8 by Wyndham Louisville Airport also caters to the needs of corporate travelers. It has a nearby casino and WiFi and is located about 10 kilometers south of the center of Louisville.Looking for epic things to do during your spare time in Louisville? Louisville Slugger Museum and Kentucky Kingdom are just two of the enticing attractions that'll capture your imagination.
Are there any family-friendly hotels in Southern Indiana that are also business friendly?
Absolutely. You'll find some great family-friendly hotels that are also business friendly in Southern Indiana. If you're traveling to Louisville, look up Residence Inn by Marriott Louisville East/Oxmoor. It includes amenities like complimentary breakfast and a barbecue grill and has a 3-stars rating. Another option worth considering is Hilton Garden Inn Louisville Mall of St. Matthews. This 3-stars stay in Louisville is ideal for both leisure and business travelers and features WiFi, laundry facilities and plenty more. You'll discover plenty of awesome things to do with your team in Louisville. Louisville Slugger Museum and Kentucky Kingdom deliver a great day out.
Are there any 5-star business-friendly hotels in Southern Indiana?
While there aren't any 5-star business-friendly hotels in Southern Indiana, there's still a selection of stylish properties to choose from. Visiting Louisville for work? Hotel Distil, Autograph Collection is a popular option that has everything you need and more when you're on a business trip. Amenities at this 4-star property include pillow top mattresses and dining romance packages. Omni Louisville Hotel is another great pick that caters to corporate guests in Louisville. Also with a 4-star rating and featuring spa facilities and massage services, you'll find plenty to love about this hotel.
Why book your business-friendly hotel in Southern Indiana with Expedia?
Expedia is here to help you find an ideal business-friendly hotel for your upcoming work trip. From conference spaces and room service to on-site cafés and more, our stays have all the amenities you'll need to get the job done.
How can I find cheap business-friendly hotels in Southern Indiana?
Select the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Southern Indiana. Then narrow your search by your per-night budget. Choosing a stay away from the center is another way to save.
What is there to do in Southern Indiana near my business-friendly hotel?
One of the most important travel accessories for your Southern Indiana business visit is a well-thought-out itinerary for when you have some free time! Louisville Slugger Museum, Louisville Waterfront Park and Louisville Palace are some of the most popular sights if you're making your way to Louisville. Evansville also offers lots of impressive attractions, such as Mesker Park Zoo, Evansville Museum of Arts, History & Science and Koch Family Children's Museum of Evansville.