A paved courtyard with a brick pathway, trees, and a distant view of a road and buildings.

Search Vacation Homes in Southeast Iowa

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Sep 4 - Sep 6
In two months
Oct 16 - Oct 18
In three months
Nov 13 - Nov 15
In four months
Dec 11 - Dec 13

Our top choices for Southeast Iowa vacation homes

A single-story house with a stone facade, a gabled roof, and a front porch.

1. Charming One Bedroom home in Keosauqua near shops

Charming One Bedroom home in Keosauqua near shops
Keosauqua
9.2 out of 10, Wonderful, (13 reviews)
"Quiet, clean and comfortable. Nicely appointed. We saw a deer and a turkey when we stepped out of the house Sunday morning. Good communications. "
United States
Melinda L.
The price is ￥13,161
￥25,422 total
includes taxes & fees
Aug 24 - Aug 25
Charming One Bedroom home in Keosauqua near shops
A deck with a grill and chairs, a covered area with an umbrella, and a compass on the building.

2. Private Woodsy Cabin close to River and Keosauqua

Private Woodsy Cabin close to River and Keosauqua
Keosauqua
9.8 out of 10, Exceptional, (20 reviews)
"Perfect location !! Lovely place and I can't say enough about how much we loved their turkey!"
United States
Julie
The price is ￥18,598
￥31,868 total
includes taxes & fees
Aug 24 - Aug 25
Private Woodsy Cabin close to River and Keosauqua
A view through a window with a tree displaying autumn foliage.

3. Nauvoo Windmill Farmhouse 10-12 people

Nauvoo Windmill Farmhouse 10-12 people
Niota
10.0 out of 10, Exceptional, (18 reviews)
"Great stay very peaceful "
United States
larry r.
The price is ￥19,869
￥35,712 total
includes taxes & fees
Aug 31 - Sep 1
Nauvoo Windmill Farmhouse 10-12 people
A room with a wooden floor, a fireplace with a mantel, a door with glass panels, and a framed painting on the wall.

4. Grand Victorian on the Mississippi

Grand Victorian on the Mississippi
Fort Madison
9.8 out of 10, Exceptional, (32 reviews)
"The home was beautifully decorated! We enjoyed our stay."
United States
Theresa G.
The price is ￥30,836
￥69,607 total
includes taxes & fees
Sep 22 - Sep 23
Grand Victorian on the Mississippi
A wooden dock extending into calm water with trees reflecting on the surface, surrounded by a grassy area.

5. Riverside Waterfront on the Mississippi River

Riverside Waterfront on the Mississippi River
Pontoosuc
9.6 out of 10, Exceptional, (24 reviews)
"Great place good location "
United States
willmer m.
The price is ￥22,890
￥46,496 total
includes taxes & fees
Sep 20 - Sep 21
Riverside Waterfront on the Mississippi River
A spacious room with large windows offering a view of a lake and trees. There are two gray armchairs and a dining table with chairs.

6. PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets
Nauvoo
9.0 out of 10, Wonderful, (7 reviews)
"Beautiful home with an amazing view of the Mississippi River. So peaceful to sit and watch the water, boats, birds, etc. Lots to do in the area, places to eat, etc. Will definitely keep in mind again for a peaceful weekend getaway."
United States
Sonia M.
The price is ￥22,889
￥51,885 total
includes taxes & fees
Sep 5 - Sep 6
PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets
A rustic brick interior with a fireplace, a wooden stool, and a checkered rug.

7. Experience Beautiful Pioneer Home In Nauvoo!

Experience Beautiful Pioneer Home In Nauvoo!
Nauvoo
9.8 out of 10, Exceptional, (87 reviews)
"We had a great stay!"
United States
Darin B.
The price is ￥30,201
￥60,645 total
includes taxes & fees
Sep 2 - Sep 3
Experience Beautiful Pioneer Home In Nauvoo!
A spacious room with a ceiling fan, a swing chair, a sofa, and large windows offering a view of trees and water.

8. Woodland Retreat High Above the Mississippi River

Woodland Retreat High Above the Mississippi River
Hamilton
9.0 out of 10, Wonderful, (2 reviews)
"I loved this little space. It was an old Lil cottage that gave me peace and comfort. We were up there for a funeral. But the cottage made us not want to leave for the real world. my two sons one and adult and one a teen also loved it! The host was very helpful! I will be back...well maybe for vacation next time!"
United States
Roberta
The price is ￥23,604
￥41,187 total
includes taxes & fees
Aug 23 - Aug 24
Woodland Retreat High Above the Mississippi River
A single-story house with a front porch, a sliding glass door, and a small deck area.

9. Historic 1840s Lamoreaux House / Modern Addition

Historic 1840s Lamoreaux House / Modern Addition
Nauvoo
9.6 out of 10, Exceptional, (25 reviews)
"Plenty of space for our family. Good location."
United States
Chelsea S.
The price is ￥39,340
￥57,359 total
includes taxes & fees
Aug 28 - Aug 29
Historic 1840s Lamoreaux House / Modern Addition

10. Full Carriage House + Hayloft

Full Carriage House + Hayloft
Fairfield
The price is ￥31,663
￥65,726 total
includes taxes & fees
Sep 16 - Sep 17
Full Carriage House + Hayloft
A covered outdoor seating area with a table and four chairs, surrounded by a white railing and a view of green trees.

11. Riverview Orchard 2: Master Suite Studio Style

Riverview Orchard 2: Master Suite Studio Style
Hamilton
9.4 out of 10, Exceptional, (6 reviews)
"Very clean, great view, great place! Highly recommend!"
United States
Addison M.
The price is ￥15,100
￥27,121 total
includes taxes & fees
Sep 14 - Sep 15
Riverview Orchard 2: Master Suite Studio Style
A modern living room with a sofa, a wooden dining table with stools, a kitchen area with cabinets and a TV, and a hallway leading to a door.

12. Family friendly 3 bedroom home in Kahoka MO

Family friendly 3 bedroom home in Kahoka MO
Kahoka
9.2 out of 10, Wonderful, (12 reviews)
"Absolutely friendly and welcoming hosts. "
United States
Jay M.
The price is ￥25,432
￥37,520 total
includes taxes & fees
Sep 15 - Sep 16
Family friendly 3 bedroom home in Kahoka MO
A dining area with a wooden table and white chairs, a vase with flowers, and two signs on the walls.

13. Charming Family Retreat - 15 min to Nauvoo & Carthage

Charming Family Retreat - 15 min to Nauvoo & Carthage
Hamilton
10.0 out of 10, Exceptional, (31 reviews)
"Love this place we have stayed several times"
United States
Tara J.
The price is ￥15,022
￥29,735 total
includes taxes & fees
Sep 4 - Sep 5
Charming Family Retreat - 15 min to Nauvoo & Carthage
A red wooden house with a patio, outdoor seating, and a grill.

14. The Little Red House

The Little Red House
Fairfield
9.6 out of 10, Exceptional, (10 reviews)
"Beautiful house and very clean!!!"
United States
Kelli J.
The price is ￥15,578
￥33,642 total
includes taxes & fees
Aug 27 - Aug 28
The Little Red House
A house with a fire pit in the backyard, a porch, and a blue chair.

15. Cozy House

Cozy House
Biggsville
10.0 out of 10, Exceptional, (8 reviews)
"Great place for our needs!"
United States
jdl j.
The price is ￥13,590
￥27,880 total
includes taxes & fees
Aug 31 - Sep 1
Cozy House
A kitchen with a granite countertop, three bar stools, a yellow placemat, and a potted plant.

16. Home Away From Home

Home Away From Home
Biggsville
10.0 out of 10, Exceptional, (2 reviews)
"Our experience all around was good. Communication with host was easy and they worked with us great. House was clean, in a quite neighborhood and definitely better than a hotel."
United States
Thomas A.
The price is ￥16,213
￥32,176 total
includes taxes & fees
Aug 27 - Aug 28
Home Away From Home
A living room with two dark blue sofas, a white coffee table, and a small white side table. There is a framed map on the wall and a lamp on the side table.

17. Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.
Blandinsville
9.4 out of 10, Exceptional, (17 reviews)
"We loved how clean the house was. It was good for staying at for commencement at WIU. Mattresses were comfortable. Shower was nice. Very nice place to stay."
United States
Annie
The price is ￥17,310
￥25,927 total
includes taxes & fees
Aug 24 - Aug 25
Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.
A living room with a sofa, coffee table, and a staircase.

18. Family Home in Carthage

Family Home in Carthage
Carthage
10.0 out of 10, Exceptional, (17 reviews)
"Super cute little home. Beds were comfy"
United States
Jesse
The price is ￥16,523
￥31,156 total
includes taxes & fees
Sep 15 - Sep 16
Family Home in Carthage
A modern living room with a leather sofa, a wooden coffee table, and a blue armchair.

19. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"We enjoyed our peaceful stay in this clean, beautiful vacation rental. Perfect for a weekend getaway. "
United States
Lisa S.
The price is ￥17,485
￥36,554 total
includes taxes & fees
Sep 4 - Sep 5
Idyllic Biggsville Vacation Rental: 10 Mi to River
A wooden deck with a bench, a small shed, and a yellow building in a grassy area with trees and a body of water in the background.

20. Oquawka Cottage With River View

Oquawka Cottage With River View
Oquawka
9.6 out of 10, Exceptional, (8 reviews)
"Cute little cottage, very clean. Wonderful beds. Very peaceful visit. Will come again"
United States
sally
The price is ￥14,878
￥30,423 total
includes taxes & fees
Aug 23 - Aug 24
Oquawka Cottage With River View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southeast Iowa Hotel Reviews

Quality Inn & Suites Keokuk North

Quality Inn & Suites Keokuk North

8/10 Good
"The lady that was present for the breakfast was EXCELLENT. She was upbeat and happy and was very helpful. More importantly to me, she kept the area very very very clean!!!! The hot tub could use a very good cleaning. I wore DRY socks in my room for a few hours and when I went to bed, they were black. Room 213 needs a good carpet cleaning!"
Deborah 2-night trip
Posted 16 hours ago
Quality Inn & Suites Keokuk North

Find out more about Southeast Iowa

Southeast Iowa Vacation Homes information

Number of reviews
214
Accommodation
55 Vacation Homes
Lowest Price
￥25,422
Highest Price
￥69,607