A calm lake with mountains in the background.

Find Resorts & Hotels with Spas in Seneca, SC

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Check availability on Seneca Resorts & Hotels with Spas

Next weekend
Nov 6 - Nov 8
In two weeks
Nov 13 - Nov 15

Our top choices for Seneca hotels with a spa

A poolside area with outdoor seating and a view of a lake and forested hills.

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.2 out of 10, Wonderful, (289 reviews)
"Excellent in every way!"
United States
Bonnie
The price is ￥18,902
￥20,793 total
includes taxes & fees
Nov 8 - Nov 9
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel dining area with a long table, multiple chairs, and a bar in the background.

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (764 reviews)
"Room was clean and staff was friendly and helpful."
United States
Sasha
The price is ￥19,714
￥21,687 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn & Suites Seneca-Clemson Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

3. Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (698 reviews)
"The room was clean and had no odors. But the place is seriously dated even though it was clean."
United States
Greg
The price is ￥14,733
￥16,206 total
includes taxes & fees
Dec 1 - Dec 2
Best Western Seneca-Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.

4. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (792 reviews)
"Very clean room, recently renovated. Comfy bed!"
United States
Rhiannon
The price is ￥11,250
￥12,376 total
includes taxes & fees
Dec 1 - Dec 2
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

5. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (117 reviews)
"My wife and I enjoyed our stay here. 10/10 experience."
United States
Winston
The price is ￥13,235
￥21,490 total
includes taxes & fees
Nov 30 - Dec 1
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
An outdoor patio area with a fire pit, seating, and string lights.

6. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (902 reviews)
"Great stay!"
United States
Melissa
The price is ￥15,762
￥17,338 total
includes taxes & fees
Dec 2 - Dec 3
Tru by Hilton Seneca Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

7. Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
"Friendly front desk and bar staff. We had a really nice overnight stay."
United States
Sherry
The price is ￥17,174
￥21,320 total
includes taxes & fees
Nov 2 - Nov 3
Lakeside Lodge Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.

8. Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very good, (766 reviews)
"Clean rooms clean parking area nice staff all good"
United States
Barry
The price is ￥12,621
￥14,852 total
includes taxes & fees
Dec 1 - Dec 2
Quality Inn Seneca US-123
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Seneca

Pool
Breakfast included

Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

8/10 Good
"Bit of a damp smell in our room which was on the first floor. Room was clean though. Staff were nice and very helpful. Further from Clemson than we imagined unfortunately."
David 2-night trip
Posted 6 days ago
Hampton Inn & Suites Seneca-Clemson Area

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Check out the lakeside setting in Seneca - worth a picture or two! Be sure to enjoy the coffeehouses during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Lake Keowee, Keowee Key Golf Course, and Lake Hartwell. If you have extra time while you're in the area, you might want to see Oconee County Library Seneca Branch and Keowee Reservoir.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services including couples massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.