Santo Spirito Vacations from ￥217,480

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to ￥45,448 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

The Latest Santo Spirito Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Ruby Bea Hotel Florence

Ruby Bea Hotel Florence

4 out of 5
San Lorenzo
per person
Sep 10 - Sep 15
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to Florence (FLR)
9.6/10 Exceptional! (280 reviews)
Our stay here was excellent! The staff were friendly, and provided excellent recommendations for the city. The room we stayed in and the hotel were very clean and newly renovated. We will be recommending this hotel to anyone traveling to Florence!

Reviewed on Jul 21, 2025

Palazzo Firenze by Baglioni Hotels & Resorts

Palazzo Firenze by Baglioni Hotels & Resorts

5 out of 5
Historic Centre of Florence
per person
Sep 2 - Sep 5
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Florence (FLR)
9.4/10 Exceptional! (228 reviews)
I VERY MUCH ENJOYED THE STAY

Reviewed on Jul 18, 2025

Villa Neroli

Villa Neroli

4 out of 5
Coverciano
per person
Sep 22 - Sep 29
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to Florence (FLR)
9.6/10 Exceptional! (434 reviews)
Stunning grounds and location fab. Loved having a pool onsite

Reviewed on Jul 21, 2025

Grand Hotel Minerva

Grand Hotel Minerva

4 out of 5
Historic Centre of Florence
per person
Sep 17 - Sep 21
found 1 day ago
Roundtrip non-stop flight included
Tokyo (TYO) to Florence (FLR)
9.6/10 Exceptional! (1,004 reviews)
The property is conveniently located in the heart of Florence city center. The hotel is clean, staff is friendly. Breakfast and dining room foods were excellent.

Reviewed on Jul 22, 2025

Hotel Balestri

Hotel Balestri

4 out of 5
Historic Centre of Florence
per person
Sep 2 - Sep 5
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Florence (FLR)
9.2/10 Wonderful! (956 reviews)
Loved the location and cleanliness, only complaint was the pillows and beds weren't comfortable. (Mattress were hard and pillows too thin)

Reviewed on Jul 16, 2025

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santo Spirito Hotel Deals

UNA HOTELS Vittoria Firenze

UNA HOTELS Vittoria Firenze

4 out of 5
Via Pisana 59, Florence, FI
Fully refundableReserve now, pay when you stay
The price is ￥17,036 per night from Jul 27 to Jul 28
￥17,036
￥21,151 total
Jul 27 - Jul 28
includes taxes & fees
8.4/10 Very Good! (986 reviews)
"It was average really. Needs to be updated in the rooms blobby area and outside was very nice"

Reviewed on May 31, 2025

UNA HOTELS Vittoria Firenze
Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13, Florence, FI
Fully refundableReserve now, pay when you stay
The price is ￥24,400 per night from Jul 27 to Jul 28
￥24,400
￥29,251 total
Jul 27 - Jul 28
includes taxes & fees
9.6/10 Exceptional! (541 reviews)
"Staff were very helpful and professional. Speaking English was not a problem. The breakfast buffet had a lot fresh food, fruit and pastries to choose from"

Reviewed on Jul 7, 2025

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r, Florence, FI
9.2/10 Wonderful! (1,002 reviews)
"Great experience overall!"

Reviewed on Jul 11, 2025

Get rates
Palazzo Mannaioni Suites
See all 468 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santo Spirito vacation package cost?
From just ￥217,480. Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favorite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito vacation package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1,000,000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Center Of Florence.
How far in advance should I book my Santo Spirito vacation?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including vacation rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our vacation packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito vacation package?
If your vacation plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Things to do

Having fun while tasting Chianti

Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence

￥14,700
per adult
100% of travellers recommend
Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence
Florence: Pasta Making Class with Wine, Limoncello, and Cake

Florence: Pasta Class with Wine, Limoncello and Dessert

￥12,035
per adult
100% of travellers recommend
Florence: Pasta Class with Wine, Limoncello and Dessert
Florence: Santa Monaca Church Italian Opera Concert Ticket

Florence: Santa Monaca Church Italian Opera Concert Ticket

￥5,083
per adult
100% of travellers recommend
Florence: Santa Monaca Church Italian Opera Concert Ticket
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.