A tropical island with a beach, clear turquoise waters, and lush greenery.

Find hotels in Santa Isabel from ¥32,642

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Tonight
Aug 10 - Aug 11
Tomorrow
Aug 11 - Aug 12
This weekend
Aug 14 - Aug 16
Next weekend
Aug 21 - Aug 23

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Our top choices for Santa Isabel hotels

Breakfast included
Hotel
Reserve now, pay later
Airport shuttle included
Bed & breakfast

1. Cabins on paradise San Blas island

Cabins on paradise San Blas island
Narganá
¥42,453
¥46,698 total
includes taxes & fees
Aug 12 - Aug 13
Cabins on paradise San Blas island

2. Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS
Narganá
¥308,170
¥340,439 total
includes taxes & fees
Sep 10 - Sep 11
Cocoloco - Catamaran Lagoon 52F SAN BLAS

3. Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island
Narganá
United States
Ryan
¥29,675
¥32,642 total
includes taxes & fees
Aug 18 - Aug 19
Private Ocean-Front Cabin with private bathroom on San Blas Island
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Learn more about Santa Isabel

Explore pristine beaches along Santa Isabel's coastline where local fishermen can take you to nearby coral reefs for snorkeling. Hike through lush rainforest trails to spot colorful birds, then visit the town's central plaza where vendors sell fresh tropical fruits and handcrafted souvenirs.

See all hotels in Santa Isabel
A tropical island with a beach, clear turquoise waters, and lush greenery.

Top Santa Isabel Hotel Reviews

Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand

10/10 Excellent
"the view is beautiful! We were taken care of well."
Mirelys 5-night trip
Posted 2 weeks ago
Caribbean getaway: beach cottage just on the sand
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

10/10 Excellent
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door. "
Ryan 4-night trip
Posted 5 months ago
Private Ocean-Front Cabin with private bathroom on San Blas Island
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent
"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "
Dennis Or Trish H. 6-night trip
Posted 8 months ago
BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

More cheap stays in Santa Isabel

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala
¥29,675
¥32,642 total
Aug 18 - Aug 19
includes taxes & fees
10/10 Exceptional! (1 review)
Private Ocean-Front Cabin with private bathroom on San Blas Island
Cabins on paradise San Blas island

Cabins on paradise San Blas island

9.587566, -78.879820 Narganá San Blas
¥42,453
¥46,698 total
Aug 12 - Aug 13
includes taxes & fees
Cabins on paradise San Blas island
Private wood Cabins on San Blas island - private bathroom

Private wood Cabins on San Blas island - private bathroom

Wailidup Island Narganá Guna Yala
Get ratesPrivate wood Cabins on San Blas island - private bathroom
 Paradise Over the Water Cabins in San Blas

Paradise Over the Water Cabins in San Blas

G4V2 48 Narganá Guna Yala
Get rates
6/10 (1 review)
Paradise Over the Water Cabins in San Blas
Trips Guna Yala

Trips Guna Yala

Urgandi, Mamardub Narganá Guna Yala
Get ratesTrips Guna Yala
Hotel El Porvenir

Hotel El Porvenir

Isla Porvenir Narganá Guna Yala
Get ratesHotel El Porvenir

Frequently asked questions

What's the best place to stay in Santa Isabel?
Located 17 mi (27.3 km) from the heart of Santa Isabel, Cocoloco - Catamaran Lagoon 52F SAN BLAS is a top choice for your stay based on our traveler data. Two other choices for your visit to the area are Private Ocean-Front Cabin with private bathroom on San Blas Island and Private wood Cabins on San Blas island - private bathroom. See all available top hotels, or vacation rentals in Santa Isabel.
What are some of the best vacation home rentals that Santa Isabel has to offer?
Caribbean Haven Of Nature 'Preci Beach': This vacation home rental outside of Santa Isabel is located on the beach and has an outdoor pool, a fireplace, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. It offers a balcony, a garden, and a selection of games so you can immerse yourself in your vacation. See all vacation rentals in Santa Isabel.
If I need to cancel my hotel reservation in Santa Isabel, will I receive a refund?
Yes! The majority of room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Isabel.
Where can I learn more about changing or cancelling my trip to Santa Isabel?
For additional details about rescheduling or cancelling your trip to Santa Isabel, go to https://www.expedia.com/service/.
What's the best place to stay near Tocumen International Airport (PTY)?
Crowne Plaza Panama Airport is a popular 4-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.4 km) from Tocumen Intl. Airport. Other good options within close proximity to the airport include Riande Aeropuerto Hotel & Casino and Express Inn Panama International Airport Hostel.
What is staying in Santa Isabel like?
Visitors can enjoy all that Santa Isabel has to offer including its parks. There are 39 hotels and other accommodations in the surrounding area. Find out more about Santa Isabel.
What are the top places to visit in Santa Isabel?
Places to visit in the wider area include Museum, Chagres National Park, and Porvenir Museum. Check out what more to see and do in Expedia's Santa Isabel guide.
What's the seasonal weather like in Santa Isabel?
The hottest months are usually June and September with an average temp of 80°F, while the coldest months are February and March with an average of 78°F. The rainiest months in Santa Isabel are October, August, July, and November, with each month seeing an average of 12 inches of rainfall.

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