Santa Cruz Vacations from ¥340,622

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The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Tocumen Airport
¥340,622
per person
Oct 21 - Oct 26
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
8.6/10 Excellent! (1,811 reviews)
Short stay and it was good...staff at check in was very helpful.

Reviewed on Sep 13, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
¥367,850
per person
Oct 21 - Oct 26
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
8.4/10 Very Good! (1,693 reviews)
It was a beautiful stay ..enjoyed every moment

Reviewed on Sep 14, 2026

Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
¥341,830
per person
Oct 21 - Oct 26
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
8.6/10 Excellent! (1,708 reviews)
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

San Francisco
¥352,192
per person
Oct 21 - Oct 26
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
9/10 Wonderful! (1,098 reviews)
Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
¥358,134
per person
Oct 21 - Oct 26
found 1 day ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
9.6/10 Exceptional! (438 reviews)
Beautiful hotel in the middle of the city store near by but definitely need a car to see site Staff really helpful and valet was great easy in and out if you have a rental

Reviewed on Sep 14, 2026

Find the Best Santa Cruz Vacation Packages

Santa Cruz Hotel Deals

Hotel Finca Lerida

Hotel Finca Lerida

Alto Quiel Los Naranjos Chiriqui
¥25,245
¥27,821 total
Sep 15 - Sep 16
includes taxes & fees
8.8/10 Excellent! (210 reviews)
"Un buen ambiente para estar tranquilo con la naturaleza."

Reviewed on Aug 20, 2026

Hotel Finca Lerida
Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

Volcan, Via Cerro Punta Volcan Chiriqui
Fully refundableReserve now, pay when you stay
¥16,452
¥18,097 total
Sep 15 - Sep 16
includes taxes & fees
8.2/10 Very Good! (267 reviews)
"Me gusto todo. La habitación con una vista increíble, el restaurante muy bien atendido y buena cómida. La piscina climatizada es genial"

Reviewed on Aug 30, 2026

Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals
Hotel Dos Rios

Hotel Dos Rios

43, Nueva California Nueva California
¥13,134
¥14,447 total
Sep 15 - Sep 16
includes taxes & fees
Hotel Dos Rios
See all 65 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the cheapest months to go to Santa Cruz?
If you're hoping to book a cheap Santa Cruz vacation package, consider traveling in August, September and October. You're likely to find better prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for Santa Cruz?
Typically, a handful of days is enough to check out the main sights during your Santa Cruz vacation. But if you'd like to have more time to relax or go on day tours, consider extending your trip.
How to find the best Santa Cruz package deals?
Use Expedia's filters to find some terrific Santa Cruz package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your break for midweek, or browse for Santa Cruz package deals in the off-season. Switch up your travel dates and you may score even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
When to book a vacation package to Santa Cruz?
If you have your Santa Cruz vacation dates confirmed, book as early as you can to bag some terrific deals. With Expedia, you can often reserve some flights up to one year in advance. Prefer spontaneous adventures? Our last-minute deals are perfect for impromptu escapes.
How to plan a trip to Santa Cruz?
  1. Pick the perfect time to travel: Your schedule, preferred season and the type of weather you like can all influence your decision on when to visit Santa Cruz.
  2. Work out your budget: Ensure you have enough money to pay for everything from transportation and food to flights and experiences. Your accommodations will probably be the largest expense during your trip to Santa Cruz.
  3. Decide how many days away: Start by compiling a list of the activities and attractions you want to experience in Santa Cruz. Then, estimate how long you'll need at each, as well as any travel time.
  4. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left is to pick a Santa Cruz vacation package that brings all your bookings together.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.