Santa Cruz Vacations from ¥158,826

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • payments icon

    Better together

    Save up to ¥45,448 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel El Ejecutivo by Reforma Avenue
Casa Decu
Capitalia Parque Lincoln
InterContinental Presidente Mexico City by IHG
Historico Central Hotel

Find the Best Santa Cruz Vacation Packages

Santa Cruz Hotel Deals

Hyatt Regency Mexico City

Hyatt Regency Mexico City

5 out of 5
Campos Eliseos No. 204 Polanco, Chapultepec, Mexico City
Fully refundableReserve now, pay when you stay
The price is ¥32,119 per night from Sep 14 to Sep 15
¥32,119
¥38,382 total
Sep 14 - Sep 15
includes taxes & fees
9.2/10 Wonderful! (1,183 reviews)
"Recommend it!"

Reviewed on Aug 25, 2025

Hyatt Regency Mexico City
InterContinental Presidente Mexico City by IHG

InterContinental Presidente Mexico City by IHG

4 out of 5
Campos Eliseos 218, Mexico City
Fully refundableReserve now, pay when you stay
The price is ¥38,992 per night from Sep 7 to Sep 8
¥38,992
¥46,596 total
Sep 7 - Sep 8
includes taxes & fees
9.2/10 Wonderful! (1,887 reviews)
"Excellent. Amazing views"

Reviewed on Aug 21, 2025

InterContinental Presidente Mexico City by IHG
Casa Olea

Casa Olea

2 out of 5
C. de Francisco Díaz Covarrubias, 76, Mexico City, CDMX
Fully refundableReserve now, pay when you stay
The price is ¥9,087 per night from Sep 3 to Sep 4
¥9,087
¥10,859 total
Sep 3 - Sep 4
includes taxes & fees
Casa Olea
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

What to do in Santa Cruz

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.