Santa Cruz Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Santa Cruz vacation rentals

Lofts by Verticca San Francisco

Lofts by Verticca San Francisco
3.5 star property
Ojo de Agua
8.6 out of 10, Excellent, (36 reviews)
"Perfect spot, clean and safe!"
United States
Manuel
The price is ¥9,583
¥11,499 total
includes taxes & fees
May 17 - May 18
Lofts by Verticca San Francisco

Lofts by Verticca Héroes

Lofts by Verticca Héroes
2.0 star property
Ojo de Agua
The price is ¥11,673
¥14,008 total
includes taxes & fees
May 17 - May 18
Lofts by Verticca Héroes

Lofts by Verticca Villa del Real

Lofts by Verticca Villa del Real
2.0 star property
Ojo de Agua
10.0 out of 10, Exceptional, (1 review)
The price is ¥11,535
¥13,842 total
includes taxes & fees
May 17 - May 18
Lofts by Verticca Villa del Real

A09 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A09 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
The price is ¥7,690
¥12,524 total
includes taxes & fees
May 18 - May 19
A09 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Moderna, Comoda Suite Palma en Tepotzotlán centro

Moderna, Comoda Suite Palma en Tepotzotlán centro
3.0 star property
Tepotzotlán
10.0 out of 10, Exceptional, (2 reviews)
"Excelente lugar "
Mexico
Teodoro
The price is ¥10,712
¥12,854 total
includes taxes & fees
May 17 - May 18
Moderna, Comoda Suite Palma en Tepotzotlán centro

Downtown Treasure Place

Downtown Treasure Place
2.5 star property
Cuauhtémoc
8.8 out of 10, Excellent, (823 reviews)
"Service was great, place was nice and clean. "
United States
Federico
The price is ¥5,197
¥6,211 total
includes taxes & fees
May 17 - May 18
Downtown Treasure Place

A08 SUPER CITY SUITES AT PLAZA ACEQUIA

A08 SUPER CITY SUITES AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (3 reviews)
"Limpio y cómodo "
Mexico
Caleb
The price is ¥7,690
¥12,524 total
includes taxes & fees
May 17 - May 18
A08 SUPER CITY SUITES AT PLAZA ACEQUIA

A01 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A01 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
The price is ¥7,690
¥12,432 total
includes taxes & fees
Jun 15 - Jun 16
A01 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Casa Chopo

Casa Chopo
3.5 star property
Cuauhtémoc
9.4 out of 10, Exceptional, (126 reviews)
"Everything is fine, except the bathroom, it is very narrow, which makes it uncomfortable."
United States
Mario
The price is ¥7,240
¥8,652 total
includes taxes & fees
May 18 - May 19
Casa Chopo

S04 SUPER SUITE Full Service WiFiTerraza

S04 SUPER SUITE Full Service WiFiTerraza
4.0 star property
Ciudad López Mateos
The price is ¥7,896
¥12,771 total
includes taxes & fees
May 19 - May 20
S04 SUPER SUITE Full Service WiFiTerraza

cabañas en arcos del sitio

cabañas en arcos del sitio
3.0 star property
Nicolás Romero
The price is ¥22,888
¥32,409 total
includes taxes & fees
May 17 - May 18
cabañas en arcos del sitio

Pancha Flats

Pancha Flats
4.5 star property
Polanco
The price is ¥53,475
¥63,903 total
includes taxes & fees
May 19 - May 20
Pancha Flats

A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
9.4 out of 10, Exceptional, (3 reviews)
"Buenas instalaciones y ubicación para mis desplazamientos"
Mexico
ANGEL
The price is ¥7,324
¥12,085 total
includes taxes & fees
Jun 15 - Jun 16
A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Mar Mediterraneo

Mar Mediterraneo
3.5 star property
Miguel Hidalgo
6.0 out of 10, (1 review)
"El lugar es lindo… solo la cama es un cero!!! Y estaba rota la regadera, casi no salía agua caliente 😔 de ahí en fuera todo bien! "
Mexico
Ilian Asusena
The price is ¥7,778
¥11,677 total
includes taxes & fees
May 21 - May 22
Mar Mediterraneo

A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (2 reviews)
"Lo único que me disgusta es que no hay agua caliente )): Pero sin duda iré todos los 12 de cada mes "
Mexico
Jeik
The price is ¥7,210
¥11,948 total
includes taxes & fees
Jun 14 - Jun 15
A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Capitalia Antara Polanco

Capitalia Antara Polanco
4.5 star property
Polanco
9.2 out of 10, Wonderful, (270 reviews)
"Clean, elegant, and great customer service."
United States
Abraham
The price is ¥23,330
¥28,229 total
includes taxes & fees
May 19 - May 20
Capitalia Antara Polanco

A07 SUPER CITY SUITES AT PLAZA ACEQUIA

A07 SUPER CITY SUITES AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (2 reviews)
"Buen lugar tranquilo "
Mexico
Valeria
The price is ¥7,210
¥8,652 total
includes taxes & fees
Jun 1 - Jun 2
A07 SUPER CITY SUITES AT PLAZA ACEQUIA

A21 Full Suite MiniDept at Plaza Acequia

A21 Full Suite MiniDept at Plaza Acequia
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (1 review)
The price is ¥7,690
¥12,524 total
includes taxes & fees
Jun 15 - Jun 16
A21 Full Suite MiniDept at Plaza Acequia

Lago Zirahuén By HomiRent

Lago Zirahuén By HomiRent
4.0 star property
Miguel Hidalgo
9.2 out of 10, Wonderful, (26 reviews)
"Good place for sleep "
United States
Martin
The price is ¥6,263
¥7,699 total
includes taxes & fees
May 24 - May 25
Lago Zirahuén By HomiRent

Ana Polanco Apartments

Ana Polanco Apartments
3.5 star property
Polanco
9.8 out of 10, Exceptional, (245 reviews)
"Great location, super nice"
United States
Sara
The price is ¥28,033
¥33,500 total
includes taxes & fees
May 18 - May 19
Ana Polanco Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Are there vacation rentals in Santa Cruz?

Yes, you can find vacation rentals near popular points of interest in Santa Cruz, or you can go with a secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

Prime Polanco Stay With Patio, Near Shops & Cafés: This vacation home rental near Santa Cruz is located in the city center and has a balcony, a selection of games, and laundry facilities to put you at ease in your new surroundings. It has 8 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What’s there to see and do in Santa Cruz?

Explore the area and family-friendly sights such as Planetario Luis Enrique Erro, or get out into nature at a spot like Hacienda La Concepcion. Temple of San Francisco Javier and San Marcos Power Center are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties you can book for a long or short time in Santa Cruz. Vacation rentals feature extras such as patios, hot tubs, and fire pits so you'll feel just like you're at home. If you're concerned about a clean environment, vacation rentals can provide a sense of seclusion away from public hotel elevators and busy front desks while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for family trips.