San Francisco Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ¥109,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place
Price found within the past 48 hours. Click for updated prices.
  • Aug 20 - Aug 25

    Hotel Riu Plaza Panama + Flight

    Bella Vista
    4 nights
    5.0 star property
    9.0/10 - Wonderful (5,555 reviews)
    "It was very nice"
    Reviewed June 5, 2026
    Roundtrip Tokyo (NRT) - Panama City (PTY)
    NRT - PTY1 stop PTY - NRT1 stop
    ¥419,200
    ¥376,604
    per traveler
    found 10 hours ago
    Hotel Riu Plaza Panama
  • Aug 20 - Aug 25

    Megapolis Hotel Panamá + Flight

    San Francisco
    4 nights
    4.5 star property
    8.4/10 - Very Good (1,546 reviews)
    "El bufet ay muy poco personal de trabajadores para prestar un buen servicio"
    Reviewed June 4, 2026
    Roundtrip Tokyo (NRT) - Panama City (PTY)
    NRT - PTY1 stop PTY - NRT1 stop
    ¥453,329
    ¥383,363
    per traveler
    found 10 hours ago
    Megapolis Hotel Panamá
  • Aug 20 - Aug 25

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    4 nights
    4.0 star property
    9.2/10 - Wonderful (1,004 reviews)
    "The staff were so helpful and friendly. Great location and atmosphere."
    Reviewed June 3, 2026
    Roundtrip Tokyo (NRT) - Panama City (PTY)
    NRT - PTY1 stop PTY - NRT1 stop
    ¥488,976
    ¥419,800
    per traveler
    found 10 hours ago
    Central Hotel Panama Casco Viejo
  • Aug 20 - Aug 25

    Sofitel Legend Casco Viejo, Panama City + Flight

    Casco Viejo
    4 nights
    5.0 star property
    9.8/10 - Exceptional (662 reviews)
    "Amazing hotel nicely located in the extraordinary casco antiguo in Panama. Staff were helpful and friendly"
    Reviewed June 5, 2026
    Roundtrip Tokyo (NRT) - Panama City (PTY)
    NRT - PTY1 stop PTY - NRT1 stop
    ¥480,529
    ¥439,054
    per traveler
    found 10 hours ago
    Sofitel Legend Casco Viejo, Panama City
  • Aug 20 - Aug 25

    Las Americas Golden Tower Panama + Flight

    San Francisco
    4 nights
    4.0 star property
    9.0/10 - Wonderful (1,027 reviews)
    "Todo bien excepto el Parking que estaba colapsado"
    Reviewed June 3, 2026
    Roundtrip Tokyo (NRT) - Panama City (PTY)
    NRT - PTY1 stop PTY - NRT1 stop
    ¥407,031
    ¥379,282
    per traveler
    found 10 hours ago
    Las Americas Golden Tower Panama

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco

San Francisco Hotel Deals

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ¥22,241 per night from Jun 28 to Jun 29
¥22,241
¥24,465 total
Jun 28 - Jun 29
includes taxes & fees
9/10 Wonderful! (1,027 reviews)
"Todo bien excepto el Parking que estaba colapsado"

Reviewed on Jun 3, 2026

Las Americas Golden Tower Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
The price is ¥22,389 per night from Jun 19 to Jun 20
¥22,389
¥24,628 total
Jun 19 - Jun 20
includes taxes & fees
9/10 Wonderful! (1,004 reviews)
"muy bien ubicado y completemente limpio y aseado."

Reviewed on Jun 5, 2026

Courtyard by Marriott Panama Multiplaza Mall
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
The price is ¥20,161 per night from Jun 19 to Jun 20
¥20,161
¥22,177 total
Jun 19 - Jun 20
includes taxes & fees
9.6/10 Exceptional! (1,228 reviews)
"Room was clean. Staff friendly & helpful. Breakfast was good"

Reviewed on Jun 5, 2026

Ramada Plaza by Wyndham Panama Punta Pacifica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.