San Francisco Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by Fabiola Tile
  • Plan, book, travel with confidence

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    Better together

    Save up to ¥45,448 when you book a flight and hotel together*
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    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco

San Francisco Hotel Deals

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ¥18,719 per night from Aug 31 to Sep 1
¥18,719
¥20,591 total
Aug 31 - Sep 1
includes taxes & fees
8.4/10 Very Good! (925 reviews)
"El hotel es super lindo y el desayuno es muy bueno. La atención también excelente."

Reviewed on Aug 6, 2025

Sheraton Grand Panama
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ¥32,538 per night from Aug 30 to Aug 31
¥32,538
¥35,792 total
Aug 30 - Aug 31
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
"service 100/100"

Reviewed on Aug 9, 2025

JW Marriott Panama
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
The price is ¥18,483 per night from Aug 30 to Aug 31
¥18,483
¥20,331 total
Aug 30 - Aug 31
includes taxes & fees
8.2/10 Very Good! (1,015 reviews)
"Everything was fantastic, however the bed sheets could be a little more clean, restock paper towel or hand towel in the bathroom and restock drinks as well as water :). The bathroom could be little more clean. Other than that everything was perfect."

Reviewed on Aug 10, 2025

Megapolis Hotel Panamá
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.