Penrose Vacations

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Where to stay in Penrose

Find the best Penrose areas and neighborhoods for the activities you enjoy most. Learn more about Penrose
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Penrose Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
¥14,274
¥16,663 total
Oct 4 - Oct 5
includes taxes & fees
8.8/10 Excellent! (3,400 reviews)
"Breakfast was great"

Reviewed on Sep 14, 2026

Clayton Plaza Hotel & Extended Stay
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO
¥23,364
¥27,554 total
Oct 4 - Oct 5
includes taxes & fees
8.6/10 Excellent! (4,273 reviews)
"Loved the location at the Arch and walking dostance to the Baseball Patk."

Reviewed on Sep 14, 2026

Hyatt Regency St. Louis at The Arch
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
¥13,685
¥16,113 total
Sep 20 - Sep 21
includes taxes & fees
9.2/10 Wonderful! (3,243 reviews)
"The young lady at the front desk was very friendly and welcoming, which I appreciate. The breakfast was quite tasty. My only inconvenience was the air conditioner, because it was loud and it was difficult to stay asleep when it did turn on. I have stayed at the Drury Inn before many years ago so ..."

Reviewed on Sep 13, 2026

Pear Tree Inn St. Louis Airport
See all 2,014 properties in Penrose
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Penrose attractions

Julia Davis Branch Library

You can enjoy some culture when you stop by Julia Davis Branch Library in St. Louis.
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Things to do

Pappy's Smokehouse

Private Tour of St. Louis's Iconic BBQ Joints & Breweries

¥22,253
per adult
Private Tour of St. Louis's Iconic BBQ Joints & Breweries
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

¥28,016
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

¥3,798
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.