Top 10 Hotels in O Brien, FL from ￥10,260 - Competitive Prices

A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

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Pool

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1. Tru by Hilton Lake City

Lake City

Michael

￥17,196

￥19,346 total

includes taxes & fees

Aug 16 - Aug 17

Down comforters, pillowtop beds, blackout drapes, WiFi (free)

Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

2. Super 8 by Wyndham Lake City

Lake City

Mari

￥10,325

￥11,617 total

includes taxes & fees

Aug 10 - Aug 11

Premium bedding, pillowtop beds, desk, laptop workspace

3. Best Western Plus Lake City

Lake City

James

￥12,922

￥14,537 total

includes taxes & fees

Aug 16 - Aug 17

Pillowtop beds, in-room safe, desk, blackout drapes

4. Days Inn by Wyndham Lake City I-75

Lake City

Brizheet

￥9,970

￥11,216 total

includes taxes & fees

Aug 10 - Aug 11

Premium bedding, in-room safe, desk, iron/ironing board

5. Holiday Inn Express & Suites Live Oak by IHG

Live Oak

Trisha

￥16,565

￥18,221 total

includes taxes & fees

Aug 23 - Aug 24

6. Hampton Inn & Suites Lake City

Lake City

Justo

￥16,407

￥18,457 total

includes taxes & fees

Aug 30 - Aug 31

Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board

7. Comfort Suites Lake City

Lake City

KHAJA

￥15,475

￥17,409 total

includes taxes & fees

Aug 18 - Aug 19

8. Americas Best Value Inn Lake City

Lake City

Larissa

￥10,223

￥11,501 total

includes taxes & fees

Aug 10 - Aug 11

9. Motel 6 – Lake City, Fl – Medical Center

Lake City

Pennee

￥10,254

￥11,536 total

includes taxes & fees

Aug 10 - Aug 11

Desk, laptop workspace, blackout drapes, iron/ironing board

10. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Priscilla J

￥14,766

￥16,612 total

includes taxes & fees

Sep 6 - Sep 7

11. Quality Inn & Suites Live Oak I-10 Exit 283

Live Oak

Patricia

￥13,189

￥14,508 total

includes taxes & fees

Aug 19 - Aug 20

Basic Single Room | Bathroom | Hair dryer, towels

12. Regal Inn

Lake City

Samuel

￥9,201

￥10,351 total

includes taxes & fees

Aug 16 - Aug 17

Room, 2 Double Beds, Accessible, Smoking | WiFi (free), bed sheets

Room, 2 Double Beds, Accessible, Non Smoking | WiFi (free), bed sheets

13. Econo Lodge Live Oak

Live Oak

James

￥11,540

￥12,693 total

includes taxes & fees

Aug 11 - Aug 12

Desk, laptop workspace, iron/ironing board, cribs (free)

14. Days Inn by Wyndham Lake City I-10

Lake City

Serhii

￥9,339

￥10,507 total

includes taxes & fees

Aug 10 - Aug 11

Room, Multiple Beds, Non Smoking (Oversize) | Desk, iron/ironing board, WiFi (free), alarm clocks

15. Baymont by Wyndham Lake City I-75

Lake City

Cameron

￥9,119

￥10,260 total

includes taxes & fees

Aug 10 - Aug 11

Suite, 1 Bedroom, Non Smoking | Private kitchen | Coffee/tea maker, fridge, microwave, dishwasher

16. Home2 Suites by Hilton Lake City

Lake City

William

￥19,304

￥21,718 total

includes taxes & fees

Aug 16 - Aug 17

17. Quality Inn White Springs Suwanee

White Springs

william

￥9,587

￥10,546 total

includes taxes & fees

Aug 30 - Aug 31

18. Holiday Inn & Suites Lake City by IHG

Lake City

Renee

￥15,303

￥17,215 total

includes taxes & fees

Aug 16 - Aug 17

19. Fairfield Inn & Suites Lake City

Lake City

Adoniram

￥16,896

￥19,008 total

includes taxes & fees

Aug 16 - Aug 17

Premium bedding, desk, blackout drapes, soundproofing

Room, 1 King Bed, Non Smoking | Living room | Flat-screen TV

20. Palms Garden Inn

Lake City

Teresa

￥10,247

￥11,528 total

includes taxes & fees

Aug 10 - Aug 11

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City

8/10 Good

"na"

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"It was a great place to stay. Best hotel experience in a long time."

Hampton Inn & Suites Alachua I-75

10/10 Excellent

"Conveniently located near I-75, with plenty of dining options nearby, this is a great place to stay when you’re just minutes away from your next outdoor adventure. The rooms are clean and comfortable, and the breakfast is a great way to fuel up and get ready for the road."

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Everything worked great"

Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent

"The rate per night was reasonable, the breakfast was amazing, and unlimited free coffee was prefect, and the staff was very helpful and accommodating when we had an issue after the rain."

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

8/10 Good

"Christine was absolutely wonderful from beginning to end. She even came by to say hello on our first day. Very responsive. I do wish the river was closer and not quite a small walk because my in laws are elderly and couldn’t enjoy it. The walk to the river is quite tough, hard to get kayaks out to the water, It’s a very steep walk. The ac wouldn’t go any colder than 70. Only one television which is in the livingroom so that was rough. Kitchen and home Fully stocked with all the things we needed and the kids enjoyed the play room. Overall the home and the host was great for the price"

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

10/10 Excellent

"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

3430 N Us Highway 441 Lake City FL

￥9,339

￥10,507 total

Aug 10 - Aug 11

includes taxes & fees

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

￥11,532

￥12,974 total

Sep 8 - Sep 9

includes taxes & fees

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

￥12,922

￥14,537 total

Aug 16 - Aug 17

includes taxes & fees

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

￥15,475

￥17,409 total

Aug 18 - Aug 19

includes taxes & fees

Hampton Inn & Suites Alachua I-75

15930 Northwest 163rd Lane Alachua FL

￥16,688

￥18,774 total

Aug 17 - Aug 18

includes taxes & fees

9.4/10 Exceptional! (545 reviews)

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

￥17,196

￥19,346 total

Aug 16 - Aug 17

includes taxes & fees

Frequently asked questions

Where is the best place to stay in O Brien?

Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.

What's the top vacation rental in O Brien?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

Best Western Plus Lake City: Features a snack bar/deli, an indoor pool, and buffet. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

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Find hotels in O Brien, FL from ￥10,260

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for O Brien hotels

1. Tru by Hilton Lake City

2. Super 8 by Wyndham Lake City

3. Best Western Plus Lake City

4. Days Inn by Wyndham Lake City I-75

5. Holiday Inn Express & Suites Live Oak by IHG

6. Hampton Inn & Suites Lake City

7. Comfort Suites Lake City

8. Americas Best Value Inn Lake City

9. Motel 6 – Lake City, Fl – Medical Center

10. La Quinta Inn & Suite by Wyndham Lake City

11. Quality Inn & Suites Live Oak I-10 Exit 283

12. Regal Inn

13. Econo Lodge Live Oak

14. Days Inn by Wyndham Lake City I-10

15. Baymont by Wyndham Lake City I-75

16. Home2 Suites by Hilton Lake City

17. Quality Inn White Springs Suwanee

18. Holiday Inn & Suites Lake City by IHG

19. Fairfield Inn & Suites Lake City

20. Palms Garden Inn

Learn more about O Brien

Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Hampton Inn & Suites Alachua I-75

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Holiday Inn Express & Suites Live Oak by IHG

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Hampton Inn & Suites Alachua I-75

Tru by Hilton Lake City

Frequently asked questions

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