Find hotels in O Brien, FL from ￥6,798

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Feb 9 - Feb 10
Tomorrow
Feb 10 - Feb 11
This weekend
Feb 13 - Feb 15
Next weekend
Feb 20 - Feb 22

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Free WiFi, bed sheets

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.2 out of 10, Very Good, (107 reviews)
"Dog friendly and price."
United States
John
The price is ￥9,477
￥10,661 total
includes taxes & fees
Mar 1 - Mar 2
Motel 6 – Lake City, Fl – Medical Center
Lobby

Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (282 reviews)
"Clean room with plenty of towels and soaps. "
United States
Melissa
The price is ￥10,290
￥11,320 total
includes taxes & fees
Mar 10 - Mar 11
Econo Lodge Live Oak
Lobby

Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.0 out of 10, Good, (526 reviews)
"Clean spacious rooms, friendly staff, convenient location "
United States
Jerry
The price is ￥14,507
￥15,958 total
includes taxes & fees
Mar 12 - Mar 13
Quality Inn & Suites Live Oak I-10 Exit 283
Lobby

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (634 reviews)
"Friendly staff, clean though older decor, great value for the price "
United States
Vince
The price is ￥10,691
￥11,761 total
includes taxes & fees
Feb 23 - Feb 24
Quality Inn White Springs Suwanee
Double Room, Non Smoking | Laptop workspace, free WiFi

High Springs Country Inn

High Springs Country Inn
2.0 star property
High Springs
8.4 out of 10, Very Good, (20 reviews)
"Great remodel of a retro motel."
United States
Kathleen
The price is ￥9,409
￥10,585 total
includes taxes & fees
Feb 12 - Feb 13
High Springs Country Inn
Free daily buffet breakfast

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very Good, (795 reviews)
"The room was clean. Bed was comfortable. Staff very nice. Breakfast was delicious. Great experience "
United States
Frank
The price is ￥18,961
￥20,859 total
includes taxes & fees
Feb 22 - Feb 23
Holiday Inn Express & Suites Live Oak by IHG
Fountain

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (405 reviews)
"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "
United States
Julians
The price is ￥13,191
￥14,840 total
includes taxes & fees
Feb 20 - Feb 21
BlueGem Motel
Exterior

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (174 reviews)
"We had such a great time, the cabin was nice and clean and had everything you might need. We loved the little detail of the handwritten postcard and map! The fireplace area was so nice too, perfect for a little getaway! "
United States
Ellie
The price is ￥18,709
￥34,417 total
includes taxes & fees
Feb 10 - Feb 11
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Standard Room, 2 Double Beds | Blackout drapes, free WiFi, bed sheets

Royal Inn

Royal Inn
2.0 star property
Alachua
7.2 out of 10, Good, (192 reviews)
"Good value and close to highway. "
United States
Ross
The price is ￥10,188
￥11,461 total
includes taxes & fees
Feb 10 - Feb 11
Royal Inn
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (484 reviews)
"We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5. Will definitely stay again!"
United States
Libbi
The price is ￥16,373
￥18,420 total
includes taxes & fees
Feb 22 - Feb 23
Hampton Inn & Suites Alachua I-75
Desk, blackout drapes, iron/ironing board, rollaway beds

Americas Best Value Inn Alachua

Americas Best Value Inn Alachua
2.0 star property
Alachua
4.8 out of 10, (605 reviews)
"Nicer than a Marriott. "
United States
Dan
The price is ￥8,455
￥9,513 total
includes taxes & fees
Feb 10 - Feb 11
Americas Best Value Inn Alachua
Individually decorated, desk, laptop workspace, blackout drapes

Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (129 reviews)
"Easy parking next to your door and easy check in.beds are comfy and as a single parent traveler i felt safe"
United States
Diane
Cindys Motel
3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers

Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.8 out of 10, Excellent, (23 reviews)
"Awesome place to stay, beautiful location and great accommodations. Friendly staff and lots to do!"
United States
Lauren
The price is ￥4,245
￥6,798 total
includes taxes & fees
Feb 10 - Feb 11
Suwannee River Rendezvous
Studio, 1 King Bed | Premium bedding, desk, blackout drapes, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (584 reviews)
"Clean and nice staff "
United States
apollo
The price is ￥10,062
￥11,320 total
includes taxes & fees
Feb 21 - Feb 22
Palms Garden Inn
Exterior

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
"Great place"
United States
John
The price is ￥14,621
￥16,449 total
includes taxes & fees
Feb 15 - Feb 16
Holiday Inn & Suites Lake City by IHG
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,003 reviews)
"Staff and hotel were wonderful!"
United States
Sandra
The price is ￥16,980
￥19,102 total
includes taxes & fees
Feb 22 - Feb 23
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1,002 reviews)
"The staff is great"
United States
Tana
The price is ￥18,535
￥20,852 total
includes taxes & fees
Feb 22 - Feb 23
Comfort Suites Lake City
Terrace/patio

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (760 reviews)
"This is an excellent hotel while you roadtrip:)"
United States
Desiree Moreno
The price is ￥19,237
￥21,642 total
includes taxes & fees
Feb 15 - Feb 16
Home2 Suites by Hilton Lake City
Premium bedding, pillowtop beds, desk, iron/ironing board

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (194 reviews)
"Friendly staff, convenient location, clean rooms, excellent breakfast"
United States
Keith
The price is ￥16,823
￥18,925 total
includes taxes & fees
Feb 22 - Feb 23
Fairfield Inn & Suites Lake City
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (199 reviews)
"Nice and clean. Friendly staff."
United States
Jennifer
The price is ￥16,823
￥18,925 total
includes taxes & fees
Feb 22 - Feb 23
Courtyard By Marriott Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Perfect tiny house experience. Cute, clean and nice for dog walking."
Dagmara 7-night trip
Posted 2 days ago
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

More cheap stays in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL
The price is ￥9,477 per night from Mar 1 to Mar 2
￥9,477
￥10,661 total
Mar 1 - Mar 2
includes taxes & fees
8/10 Very Good! (106 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are La Quinta Inn & Suite by Wyndham Lake City and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Offers buffet, an outdoor pool, and complimentary wired internet access. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Explore a world of travel with Expedia