Mesopotamia Vacations from ￥453,493
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
The Latest Mesopotamia Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Emperador Hotel Buenos Aires
El Centro
￥558,701
per person
Dec 27 - Jan 1
found 1 hour ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
8.8/10 Excellent! (510 reviews)
The room was very spacious, comfortable, and beautiful. The staff provided excellent service and were always friendly and attentive. Overall, a great experience!
Reviewed on Oct 23, 2026
Find the Best Mesopotamia Vacation Packages
Mesopotamia Hotel Deals
Marriott Corrientes Hotel
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
￥23,868
￥23,868 total
Nov 1 - Nov 2
9.8/10 Exceptional! (51 reviews)
"2 cosas, faltaban toallas en el baño y otra que no me atendieron para poder pedir otra reserva"
Reviewed on Oct 18, 2026
Costarenas Hotel & Spa
12 de Abril y Quiros Colon Entre Rios
Fully refundableReserve now, pay when you stay
￥19,060
￥19,060 total
Oct 26 - Oct 27
8.8/10 Excellent! (65 reviews)
"Estaba todo muy lindo"
Reviewed on Jun 8, 2026
O2 Hotel Gualeguaychú
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
￥6,933
￥6,933 total
Oct 26 - Oct 27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Mesopotamia attractions
El Palmar National Park
8.0/10 (2 reviews)
Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.
Costanera de Corrientes
9.0/10 (4 reviews)
Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area.
Basilica Nuestra Senora De Itati
Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
Termas de Federacion
10.0/10 (2 reviews)
Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls.
Concepción del Uruguay City Racetrack
You can take time to visit Concepción del Uruguay City Racetrack during your travels to Concepción del Uruguay. Experience the area's art scene and museums.
Termas Concepcion Entrerios
Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this amusement park in Concepción del Uruguay. Experience the area's art scene and museums.
Isla Cambacua Beach
8.8/10 (5 reviews)
Why not spend a lazy afternoon at Isla Cambacua Beach during your trip to Concepción del Uruguay? Experience the area's art scene and museums.
Victoria Beach
If a restful vacation is part of your travel plans, Victoria Beach might be the perfect place to seek out during your trip to Victoria. Make some time to visit the monuments while you're in the area.
Frequently asked questions
How much does a Mesopotamia vacation package cost?
Maybe less than you might think — from only ￥453,493, actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don't worry if you're rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
