Mesopotamia Vacations from ￥476,252

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥109,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Mesopotamia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Mayoral

Hotel Mayoral

3 out of 5
Price was ￥495,420, price is now ￥476,252 per person
￥476,252
per person
Sep 17 - Sep 23
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Rosario (ROS)
7.8/10 Good! (93 reviews)

Carat Apart Boutique

Carat Apart Boutique

2.5 out of 5
Rosario Centro
Price was ￥527,835, price is now ￥509,820 per person
￥509,820
per person
Sep 17 - Sep 23
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Rosario (ROS)
9.4/10 Exceptional! (56 reviews)
An amazing hotel with exceptionally warm and welcoming staff. Although we were foreigners who did not speak Spanish, they made us feel completely comfortable. The room was very spacious, and the breakfast was excellent. As an added perk, the hotel also provides a complimentary pass to a nice nearby gym.

Reviewed on Jul 18, 2026

Roberta Rosa de Fontana Suites

Roberta Rosa de Fontana Suites

3 out of 5
Rosario Centro
Price was ￥494,220, price is now ￥477,838 per person
￥477,838
per person
Sep 17 - Sep 23
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Rosario (ROS)
9.2/10 Wonderful! (286 reviews)
Parking one block away 16000.00 AR

Reviewed on Jul 23, 2026

Pullman Rosario City Center Hotel

Pullman Rosario City Center Hotel

4 out of 5
Price was ￥547,054, price is now ￥529,230 per person
￥529,230
per person
Sep 17 - Sep 23
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Rosario (ROS)
8.6/10 Excellent! (280 reviews)
I arrived around 11 AM and was told the room wasn’t available. Because I was extremely tired after + 12 hours of flying, I insisted and was offered the room for an additional ~$75. It was the same room, not an upgrade, which made it feel like the room was already ready and that it was more about not allowing early access. I understand early check-in policies and that it’s up to the hotel. However, considering it wasn’t that early, it wasn’t high season, and I’m a repeat guest, I feel the situation could have been handled differently.

Reviewed on Jan 29, 2026

Holiday Inn Rosario by IHG

Holiday Inn Rosario by IHG

3.5 out of 5
Rosario Centro
Price was ￥546,306, price is now ￥529,134 per person
￥529,134
per person
Sep 17 - Sep 23
found 1 day ago
Roundtrip flight included
Tokyo (HND) to Rosario (ROS)
9.4/10 Exceptional! (378 reviews)
Excelente lugar para descansar en la ciudad de Rosario, es muy céntrico y se puede caminar en sus alrededores

Reviewed on Jun 12, 2026

Find the Best Mesopotamia Vacation Packages

Stay near popular Mesopotamia attractions

A large church with a prominent dome and two bell towers.

Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
See properties

Frequently asked questions

How much does a Mesopotamia vacation package cost?
Maybe less than you might think — from only ￥476,252, actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don't worry if you're rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.