Mesopotamia Vacations

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Find the Best Mesopotamia Vacation Packages

Mesopotamia Hotel Deals

Hotel y Spa Termas del Este

Hotel y Spa Termas del Este

3 out of 5
Presidente Raúl alfonsín 877, Federacion
Fully refundableReserve now, pay when you stay
8.4/10 Very Good! (12 reviews)
"good for a 1 night stay"

Reviewed on Aug 16, 2025

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Hotel y Spa Termas del Este
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5, Concordia, Entre Rios
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (350 reviews)
"Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful."

Reviewed on Dec 31, 2024

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Hathor Concordia
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros, Colon, Entre Rios
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (55 reviews)
Nice area, okay hotel
"The hotel is in a nice area, right by the water. Lots of restaurants within walking distance. The hotel itself was ok- not especially nice but not unclean. The hotel gave us 2 free drink coupons which we appreciated. At night there was a live band in the bar/lobby area. The hotel seemed overpriced ..."

Reviewed on Jul 26, 2019

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Costarenas Hotel & Spa
See all 500 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mesopotamia vacation package cost?
Maybe less than you might think — from only , actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don't worry if you're rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.