Mesopotamia Vacations from ¥391,533

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The Latest Mesopotamia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
SuMa Recoleta Hotel

SuMa Recoleta Hotel

Buenos Aires Central Business District
¥391,533
per person
Sep 19 - Sep 22
found 15 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
8/10 Very Good! (181 reviews)
Estaba todo bien. Solo que casi me quedo encerrada en el baño de recepción. Pero de ahí todo bien.

Reviewed on Aug 4, 2026

Palacio Duhau - Park Hyatt Buenos Aires

Palacio Duhau - Park Hyatt Buenos Aires

Recoleta
¥506,918
per person
Sep 19 - Sep 22
found 15 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.4/10 Exceptional! (515 reviews)
Excelente hotel. Suite Park vale a estadia Café da manhã muito bom. Localização perfeita. Lindo jardim.

Reviewed on Jul 4, 2026

Bulnes Eco Suites

Bulnes Eco Suites

Palermo
¥396,085
per person
Sep 19 - Sep 22
found 15 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.4/10 Exceptional! (1,271 reviews)
The apartment ws clean, spacious and luminous. The international plug was very usful for us.

Reviewed on Jul 29, 2026

Principado Downtown

Principado Downtown

Microcentro
¥397,233
per person
Sep 19 - Sep 22
found 15 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9/10 Wonderful! (1,021 reviews)
The breakfast was great

Reviewed on Aug 7, 2026

1828 Smart Hotel

1828 Smart Hotel

Palermo
¥417,895
per person
Sep 19 - Sep 22
found 15 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.4/10 Exceptional! (719 reviews)
Great location! Lovely comfortable spacious room.

Reviewed on Aug 2, 2026

Find the Best Mesopotamia Vacation Packages

Mesopotamia Hotel Deals

Marriott Corrientes Hotel

Marriott Corrientes Hotel

Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
¥21,140
¥21,140 total
Aug 16 - Aug 17
9.8/10 Exceptional! (40 reviews)
"It’s ok"

Reviewed on Aug 4, 2026

Marriott Corrientes Hotel
Hathor Concordia

Hathor Concordia

Ruta Nacional 14-km 264.5 Concordia Entre Rios
8.6/10 Excellent! (384 reviews)
"AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road."

Reviewed on Dec 22, 2025

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Hathor Concordia
Costarenas Hotel & Spa

Costarenas Hotel & Spa

12 de Abril y Quiros Colon Entre Rios
Fully refundableReserve now, pay when you stay
¥19,168
¥19,168 total
Aug 13 - Aug 14
8.8/10 Excellent! (64 reviews)
"Estaba todo muy lindo"

Reviewed on Jun 8, 2026

Costarenas Hotel & Spa
See all 531 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mesopotamia attractions

A large church with a prominent dome and two bell towers.

Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
See properties
A dirt path through a dense palm tree forest.

El Palmar National Park

8.0/10 (2 reviews)
Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.
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A stone pergola with steps leading up to it, surrounded by greenery and a clear sky.

Costanera de Corrientes

9.0/10 (4 reviews)
Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area.
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A pathway lined with trees and a wrought iron archway leading to a building with a red facade.
Photo by Carolzinha

San José Palace

9.6/10 (4 reviews)
You can spend an afternoon exploring the galleries in San José Palace in Caseros.
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Termas de Federacion

10.0/10 (2 reviews)
Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls.
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Victoria Beach

If a restful vacation is part of your travel plans, Victoria Beach might be the perfect place to seek out during your trip to Victoria. Make some time to visit the monuments while you're in the area.
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Termas Concepcion Entrerios

Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this amusement park in Concepción del Uruguay. Experience the area's art scene and museums.
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Frequently asked questions

How much does a Mesopotamia vacation package cost?
Maybe less than you might think — from only ¥391,533, actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don't worry if you're rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.