Mesopotamia Vacations from ￥259,147

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    Better together

    Save up to ￥45,448 when you book a flight and hotel together*
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    Find the right fit

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    Plan, book, and manage your trip all in one place

The Latest Mesopotamia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Mio Buenos Aires

Mio Buenos Aires

4.5 out of 5
Recoleta
per person
Sep 20 - Sep 24
found 21 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (BUE)
9.4/10 Exceptional! (535 reviews)
Great place to stay!!

Reviewed on Jul 2, 2025

Estancia Villa Maria

Estancia Villa Maria

3.5 out of 5
per person
Sep 20 - Sep 24
found 20 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (BUE)
9.4/10 Exceptional! (93 reviews)
Gorgeous, peaceful property and the staff was very friendly and attentive. We enjoyed our quiet time here at the end of a whirlwind trip.

Reviewed on Apr 29, 2025

Palacio Duhau - Park Hyatt Buenos Aires

Palacio Duhau - Park Hyatt Buenos Aires

5 out of 5
Recoleta
per person
Sep 20 - Sep 24
found 21 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (BUE)
9.4/10 Exceptional! (434 reviews)
The place is amazing, the staff is welcoming but in the restaurants / cafe / bar they can be a bit slow, really attentive but slow. The property makes up for it, great beds, great accommodation and good food.

Reviewed on Apr 28, 2025

Alvear Palace Hotel

Alvear Palace Hotel

5 out of 5
Recoleta
per person
Sep 20 - Sep 24
found 21 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (BUE)
9.6/10 Exceptional! (839 reviews)
The hotel is nice, and the brunch is fantastic.

Reviewed on Jul 9, 2025

Four Seasons Hotel Buenos Aires

Four Seasons Hotel Buenos Aires

5 out of 5
Buenos Aires Central Business District
per person
Sep 20 - Sep 24
found 21 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (BUE)
9.4/10 Exceptional! (254 reviews)
This is an amazing property. We enjoyed our stay. The staff are very attentive and cordial. We would stay at the Four Seasons Buenos Aires again.

Reviewed on Jun 24, 2025

Find the Best Mesopotamia Vacation Packages

Mesopotamia Hotel Deals

O2 Hotel Gualeguaychú
O2 Hotel Gualeguaychú
2.5 out of 5
115 3 de Febrero, Gualeguaychú, Entre Ríos
Fully refundableReserve now, pay when you stay
The price is ￥5,446 per night from Jul 16 to Jul 17
￥5,446
￥5,446 total
Jul 16 - Jul 17
7.4/10 Good! (58 reviews)
"Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice."

Reviewed on Jan 2, 2025

O2 Hotel Gualeguaychú
Hathor Concordia
Hathor Concordia
3 out of 5
Ruta Nacional 14-km 264.5, Concordia, Entre Rios
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (345 reviews)
"Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful."

Reviewed on Dec 31, 2024

Get rates
Hathor Concordia
Hotel La Bahia
Hotel La Bahia
2.5 out of 5
San Lorenzo 553, Federacion, Entre Rios (province)
Get rates
Hotel La Bahia
See all 474 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mesopotamia vacation package cost?
Maybe less than you might think --- from only ￥259,147, actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don't worry if you're rethinking your Mesopotamia vacation package --- you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.