Mesopotamia Vacations from ￥407,665

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The Latest Mesopotamia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Byblos Palermo Soho

Byblos Palermo Soho

3.5 out of 5
Palermo
Price was ￥532,868, price is now ￥407,665 per person
￥407,665
per person
Sep 19 - Sep 24
found 18 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
8.2/10 Very Good! (524 reviews)

Estancia Villa Maria

Estancia Villa Maria

4 out of 5
Price was ￥867,808, price is now ￥437,729 per person
￥437,729
per person
Sep 18 - Sep 23
found 18 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.4/10 Exceptional! (113 reviews)
A fairytale stay! The staff was incredible and kind, the property was stunning and the asado incredible. If you are going to Buenos Aires, this is a MUST stay location.

Reviewed on May 11, 2026

Krista Boutique Hotel

Krista Boutique Hotel

4 out of 5
Palermo
Price was ￥568,375, price is now ￥429,153 per person
￥429,153
per person
Sep 19 - Sep 24
found 18 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.2/10 Wonderful! (367 reviews)
Nuestra experiencia en el Hotel Krista de Buenos Aires fue excelente. La habitación era amplia, muy cómoda y perfecta para viajar en familia. Todo el personal fue muy amable y atento durante nuestra estadía, haciéndonos sentir bienvenidos desde el primer momento. El desayuno fue delicioso, con muy buena variedad y productos frescos. Además, es un hotel realmente family friendly, ideal para quienes viajan con niños o adolescentes. Sin duda, volveríamos a hospedarnos aquí en una próxima visita a Buenos Aires. ⭐⭐⭐⭐⭐

Reviewed on Jul 28, 2026

CasaSur Bellini

CasaSur Bellini

4 out of 5
Palermo
Price was ￥600,223, price is now ￥453,666 per person
￥453,666
per person
Sep 19 - Sep 24
found 18 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.2/10 Wonderful! (877 reviews)

1828 Smart Hotel

1828 Smart Hotel

4.5 out of 5
Palermo
Price was ￥571,814, price is now ￥436,155 per person
￥436,155
per person
Sep 19 - Sep 24
found 18 hours ago
Roundtrip flight included
Tokyo (TYO) to Buenos Aires (EZE)
9.4/10 Exceptional! (719 reviews)
Amazing concierges. I had a very difficult request… needed to find a specialized veterinarian to complete complicated paperwork so I could bring my dog back to the United States. His assistance made all the difference, and I am incredibly grateful.

Reviewed on Jul 29, 2026

Find the Best Mesopotamia Vacation Packages

Mesopotamia Hotel Deals

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is ￥21,388 per night from Aug 16 to Aug 17
￥21,388
￥21,388 total
Aug 16 - Aug 17
9.8/10 Exceptional! (39 reviews)
"Me da mucho gusto que Corrientes tenga un hotel de esta categoría. El personal es excelente, desde el front desk hasta las personas de mantenimiento. Cuando supieron que íbamos a casarnos nos enviaron una bandeja de refreshments con una hermosa tarjeta de felicitación. La presión y temperatura de ..."

Reviewed on Jun 6, 2026

Marriott Corrientes Hotel
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros Colon Entre Rios
Fully refundableReserve now, pay when you stay
The price is ￥19,393 per night from Aug 1 to Aug 2
￥19,393
￥19,393 total
Aug 1 - Aug 2
8.8/10 Excellent! (64 reviews)
"Estaba todo muy lindo"

Reviewed on Jun 8, 2026

Costarenas Hotel & Spa
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is ￥5,840 per night from Aug 3 to Aug 4
￥5,840
￥5,840 total
Aug 3 - Aug 4
O2 Hotel Gualeguaychú
See all 529 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mesopotamia attractions

A large church with a prominent dome and two bell towers.

Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
See properties

Frequently asked questions

How much does a Mesopotamia vacation package cost?
Maybe less than you might think — from only ￥407,665, actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don't worry if you're rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.