A river winding through a dense forest.

Find hotels in Mesopotamia from ￥5,567

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 9 - Sep 10
Tomorrow
Sep 10 - Sep 11
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Filter by

Property class

Guest rating

Our top choices for Mesopotamia hotels

A compact kitchen with white cabinets, a microwave, a kettle, and a wooden dining table.
A modern bedroom with a bed, a dining area with a table, and a kitchen in the background.
A hotel room with two beds, a dining table, a vase with flowers, and a large painting on the wall.
A modern building with a red section, a pool, and outdoor umbrellas.

1. Hotel Dinastie Palace

Hotel Dinastie Palace
Chajarí
￥18,985
￥22,972 total
Sep 17 - Sep 18
Hotel Dinastie Palace
A covered outdoor swimming pool with lounge chairs and a waterfall feature.
A restaurant with outdoor seating, a pool view, and a bar area with wine glasses.
A modern bathroom with a large bathtub, a view of trees through a window, and a towel rack.
A breakfast setup with a bowl of fruit, a vase with a plant, a pitcher, a glass of orange juice, and cups of coffee and tea on a table by a window with a view of a balcony and outdoor furniture.

2. Hathor Concordia

Hathor Concordia
Concordia
Brazil
Ivon
￥9,400
￥11,091 total
Oct 9 - Oct 10
Hathor Concordia
A spacious lobby with black and red seating, a reception desk, and a staircase connecting two levels.
A modern lounge area with black leather sofas, glass tables, and red chairs.
A hotel room with a large bed, a nightstand, a wall-mounted lamp, and a sliding glass door leading to a balcony.
A hotel with multiple floors, balconies, and a sign reading "GUALEGUAYCHÚ".

3. O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú
Gualeguaychú
United States
Allan
￥5,567
￥5,567 total
Sep 14 - Sep 15
O2 Hotel Gualeguaychú
A swimming pool with clear water, surrounded by palm trees and a modern building in the background.
A hotel room with a large bed, bedside lamps, a nightstand, a desk with a computer, a mirror, and a bathroom with a bathtub.
A modern bedroom with a large bed, a glass-enclosed bathtub, and a view of the city through large windows.
A buffet setup with various food items and beverages, including bread, pastries, and a coffee station.

4. Mayim Hotel Termal & SPA

Mayim Hotel Termal & SPA
Concordia
Costa Rica
Federico
￥12,960
￥12,960 total
Oct 8 - Oct 9
Mayim Hotel Termal & SPA
A hotel room with two beds, a nightstand, a telephone, and a framed picture on the wall.
A breakfast buffet with various food items, a coffee machine, and a toaster.
A bathroom with a shower, toilet, bidet, and marble tiles.
A modern hotel lobby with a seating area, a reception desk, and a marble floor.

5. Ayres Inn

Ayres Inn
Federal
￥9,223
￥9,223 total
Sep 10 - Sep 11
Ayres Inn
A swimming pool with lounge chairs and two thatched-roof structures.
A cozy living room with a brick wall, a television mounted above a sofa, a wooden table with chairs, and a window with curtains.
A room with a brick wall, a bed with orange bedding, a television mounted on the wall, and a door labeled "SALIDA".
A row of single-story, light-colored mobile homes with small windows and a flat roof. Each unit has a small porch area with a wooden bench.

6. Bungalows Mexico

Bungalows Mexico
Concepción del Uruguay
Argentina
Roberto Alejandro
￥6,675
￥6,675 total
Sep 17 - Sep 18
Bungalows Mexico
A hotel with a well-lit exterior, a wooden fence, and a garden with various plants and a palm tree.
A reception area with a wooden ceiling, a reception desk, two vases with branches, and a table with candles.
An outdoor deck with wooden furniture and white umbrellas, overlooking a building with a red roof.
A breakfast buffet with various pastries, fruits, and beverages.

7. Club Valle Termal Resort

Club Valle Termal Resort
Federacion
United States
Fernando
￥7,349
￥7,349 total
Sep 18 - Sep 19
Club Valle Termal Resort
A swimming pool with a night-time view of buildings, palm trees, and a staircase.
A covered outdoor seating area with a pergola structure, potted plants, and a statue.
A modern building with a stone facade, a staircase, and surrounding greenery.
A building with a sign reading 'ANJANA apar' surrounded by greenery and a thatched structure.

8. Complejo Anjana

Complejo Anjana
Federación
Canada
David
￥5,254
￥5,254 total
Sep 22 - Sep 23
Complejo Anjana
A large house with a swimming pool surrounded by lush greenery and a river in the background.
A dining table set for two with a view of a lake and greenery.
A resort with multiple swimming pools, lounge areas, and a large house.
A pathway leading to a building surrounded by palm trees and yellow flowers.

9. La Regina Lodge

La Regina Lodge
Municipo de Itati
Brazil
Marcos
￥8,149
￥8,149 total
Oct 4 - Oct 5
La Regina Lodge
A swimming pool with a wooden deck and a person in a swimsuit.
A bedroom with a bed, a chair, a nightstand, a window with curtains, and a painting on the wall.
A kitchen with a wooden island, a refrigerator, a stove, and hanging utensils.
A dining area with a table, chairs, a sofa, and a television.

10. Mombiri

Mombiri
Esquina
￥5,323
￥5,323 total
Oct 10 - Oct 11
Mombiri
A swimming pool with steps leading into it, surrounded by lounge chairs and umbrellas, with a building in the background.
A dining area with a table set for two, a painting of a cityscape, and a view of the outside.
A residential area with a swimming pool, lounge chairs, and a well-maintained lawn.
A kitchen with a white sofa, a dining table with chairs, a brick wall, and a wooden ceiling.

11. Complejo La Loma

Complejo La Loma
Federacion
Canada
Logan
￥5,373
￥5,576 total
Sep 20 - Sep 21
Complejo La Loma
A modern indoor swimming pool with a wooden deck, large windows offering a view of the sea and boats.
A hotel reception area with a reception desk, a waiting area with a sofa, and a large glass door leading outside.
A rooftop terrace with a wooden deck, outdoor seating, and potted plants.

12. Donsuites Apart Hotel

Donsuites Apart Hotel
Corrientes
United States
Nora
￥10,046
￥10,046 total
Sep 15 - Sep 16
Donsuites Apart Hotel
A kitchen with a double sink, a stove, and cabinets.
An open door leading to an outdoor area with a bench and a playground.
A room with a bunk bed, a small table, and a stone wall.
A compact room with a bed, a dining table, and a kitchenette.

13. Cabañas Peumayen

Cabañas Peumayen
Colón
￥9,838
￥9,838 total
Sep 10 - Sep 11
Cabañas Peumayen
A dining area with tables, chairs, a wooden cabinet, and a mirror on the wall.
A hallway with a wooden chair, a table, and a potted plant.
A building with a stone facade, a visible entrance, and a sign with a blue 'H' indicating a hotel.
A bedroom with a bed, a chair, a desk, a shelf with plants, and an air conditioning unit.

14. hotel san lorenzo design

hotel san lorenzo design
Corrientes
Brazil
Felipe Martin
￥6,101
￥6,101 total
Sep 15 - Sep 16
hotel san lorenzo design
An outdoor dining setup with a table set for a meal, surrounded by a scenic landscape.
A kitchen with a central island, wooden cabinets, and a chimney.
A swimming pool with lounge chairs and umbrellas, surrounded by greenery and buildings with red roofs.
A rustic kitchen with a brick fireplace, hanging copper pots, and a wooden table with a candle.

15. Rincón del Socorro

Rincón del Socorro
Mercedes
United States
Anonymous traveler
￥119,928
￥119,928 total
Sep 11 - Sep 12
Rincón del Socorro
A restaurant with tables set for dining, featuring red chairs and a glass partition wall.
A covered outdoor area with a stone pathway leading to a building.
A living room with a beige sofa, a wooden coffee table with magazines, and a vase of flowers.
A covered outdoor area with a wooden structure, surrounded by lush greenery and trees.

16. Rio Arriba Suites Apartments y Resto

Rio Arriba Suites Apartments y Resto
Bella Vista
Brazil
Anonymous traveler
￥10,272
￥10,272 total
Sep 22 - Sep 23
Rio Arriba Suites Apartments y Resto
An aerial view of a resort with a large swimming pool, multiple buildings, and a parking area.
A hotel room with two beds, a small desk, a television, and a window with a view.
A spacious living area with a white sofa, a coffee table, and a dining area in the background.
A hotel with a spa, pool, and restaurant.

17. Hotel y Spa Termas del Este

Hotel y Spa Termas del Este
Federacion
Canada
Chase
￥8,413
￥8,413 total
Sep 13 - Sep 14
Hotel y Spa Termas del Este
A hotel exterior with a stone facade, a well-lit entrance, and a paved area with small trees.
A poolside setting with a stone wall, a glass of orange juice, a plate with food, and an open book.
A hallway with large windows, a radiator, and red vases.
A person sitting on a bed in a hotel room, holding a remote control, with a tray of breakfast items in front of them. A television displaying the Netflix logo is mounted on the wall.

18. Hotel Rio

Hotel Rio
Chajarí
Argentina
SANTIAGO
￥13,189
￥13,189 total
Sep 10 - Sep 11
Hotel Rio
A covered outdoor seating area with a table and benches, surrounded by a transparent enclosure.
A spacious living room with a fireplace, a wooden bench, and a sofa.
A small, enclosed outdoor kitchen area with a table and benches, a water heater, and a window with shutters.
A compact kitchen with white cabinets, a microwave, a stove, and a refrigerator.

19. Pinares del Norte

Pinares del Norte
Federación
￥13,696
￥13,696 total
Sep 10 - Sep 11
Pinares del Norte
A modern outdoor seating area with wooden tables and benches, surrounded by lush greenery and flowering plants.
A modern interior with a sectional sofa, wooden chairs, a glass display case with pottery, and a large window with a view.
A spacious lounge area with a large seating arrangement, a central coffee table, and a decorative wooden structure.
A modern lobby with a curved wooden wall, a central light fixture, and a reception desk.

20. Marriott Corrientes Hotel

Marriott Corrientes Hotel
Corrientes
Australia
Marcus
￥21,982
￥21,982 total
Sep 27 - Sep 28
Marriott Corrientes Hotel
View all properties

Vacation Rentals in Mesopotamia

Condo
A hotel with a well-lit exterior, a wooden fence, and a garden with various plants and a palm tree.
A reception area with a wooden ceiling, a reception desk, two vases with branches, and a table with candles.
An outdoor deck with wooden furniture and white umbrellas, overlooking a building with a red roof.
A breakfast buffet with various pastries, fruits, and beverages.

Club Valle Termal Resort

Club Valle Termal Resort
Federacion
"La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto."
Club Valle Termal Resort
Cabin
A swimming pool with lounge chairs and two thatched-roof structures.
A cozy living room with a brick wall, a television mounted above a sofa, a wooden table with chairs, and a window with curtains.
A room with a brick wall, a bed with orange bedding, a television mounted on the wall, and a door labeled "SALIDA".
A row of single-story, light-colored mobile homes with small windows and a flat roof. Each unit has a small porch area with a wooden bench.

Bungalows Mexico

Bungalows Mexico
Concepción del Uruguay
"Todo como esperaba. Muy bien. Amables. Lugar en condiciones. "
Bungalows Mexico
Aparthotel
A swimming pool with a night-time view of buildings, palm trees, and a staircase.
A covered outdoor seating area with a pergola structure, potted plants, and a statue.
A modern building with a stone facade, a staircase, and surrounding greenery.
A building with a sign reading 'ANJANA apar' surrounded by greenery and a thatched structure.

Complejo Anjana

Complejo Anjana
Federación
"Very help full staff. Don't speak English but speak slowly Spanish for help you to understand. Very good breakfast"
Complejo Anjana
Aparthotel
A modern indoor swimming pool with a wooden deck, large windows offering a view of the sea and boats.
A hotel reception area with a reception desk, a waiting area with a sofa, and a large glass door leading outside.
A rooftop terrace with a wooden deck, outdoor seating, and potted plants.

Donsuites Apart Hotel

Donsuites Apart Hotel
Corrientes
"Loved this place, super clean, and the staff were very nice and helpful😍"
Donsuites Apart Hotel
Aparthotel
A swimming pool with steps leading into it, surrounded by lounge chairs and umbrellas, with a building in the background.
A dining area with a table set for two, a painting of a cityscape, and a view of the outside.
A residential area with a swimming pool, lounge chairs, and a well-maintained lawn.
A kitchen with a white sofa, a dining table with chairs, a brick wall, and a wooden ceiling.

Complejo La Loma

Complejo La Loma
Federacion
"Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining area. There is a communal pool outside in the courtyard as well with lounge chairs. Breakfast was decent as well. Parking on site. I would stay here again for sure, but would be better for multiple...
Complejo La Loma
See all vacation rentals
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Mesopotamia attractions

A dirt path through a dense palm tree forest.

El Palmar National Park

8.0/10 (2 reviews)
Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.
See properties
A large church with a prominent dome and two bell towers.

Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
See properties
A stone pergola with steps leading up to it, surrounded by greenery and a clear sky.

Costanera de Corrientes

9.0/10 (4 reviews)
Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area.
See properties

Termas de Federacion

10.0/10 (2 reviews)
Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls.
See properties

Concepción del Uruguay City Racetrack

You can take time to visit Concepción del Uruguay City Racetrack during your travels to Concepción del Uruguay. Experience the area's art scene and museums.
See properties

Victoria Beach

If a restful vacation is part of your travel plans, Victoria Beach might be the perfect place to seek out during your trip to Victoria. Make some time to visit the monuments while you're in the area.
See properties

Portal Carambola

You can take time to visit Portal Carambola during your travels to Concepción. While you're in the area, wander around the parks.
See properties

Termas Concepcion Entrerios

Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this amusement park in Concepción del Uruguay. Experience the area's art scene and museums.
See properties

Learn more about Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

See all hotels in Mesopotamia
A waterfall surrounded by dense forest and small islands.

Top Mesopotamia Hotel Reviews

Esplendor by Wyndham Savoy Rosario

Esplendor by Wyndham Savoy Rosario

8/10 Good
"Todo muy bien"
Fernando 1-night trip
Posted 3 days ago
Esplendor by Wyndham Savoy Rosario
Hathor Concordia

Hathor Concordia

8/10 Good
"Cómo en casa. Excelente atención."
gustavo 3-night trip
Posted 5 days ago
Hathor Concordia
Marriott Corrientes Hotel

Marriott Corrientes Hotel

10/10 Excellent
"Impecable"
Lau 1-night trip
Posted 8 days ago
Marriott Corrientes Hotel
La Alondra Casa De Huéspedes

La Alondra Casa De Huéspedes

10/10 Excellent
"Excelente opción"
Pedro 1-night trip
Posted 9 days ago
La Alondra Casa De Huéspedes
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

10/10 Excellent
"Hola,todos los chicos con excelente atencion,muy dispuestos y nos hicieron muy buenas recomendaciones,si tuviera que opinar al fuera de lo expresado,es el servicio de desayuno,muy muy muy básico,2 medialunas chicas " peladas " y 3 tostadas y bien tostadas,sería agradable pongan alguna otra cosita en el platillo,sería más gratificante a la hora del desayuno ,todo lo demás 10 puntos,abrazo a todos Migue y Cris"
Miguel Angel 3-night trip
Posted 10 days ago
O2 Hotel Gualeguaychú
InterTower Hotel

InterTower Hotel

10/10 Excellent
"We thoroughly enjoyed our stay at the Intertower Hotel and found the staff to be incredibly friendly and helpful. The breakfasts were ample and delicious. The cleaning staff did a superb job. The front desk staff were knowledgeable and very helpful with advice about local things to do. We really liked the option of having two adjoining rooms with the connecting door for our family of five. We would highly recommend!"
Jamin 7-night trip
Posted 11 days ago
InterTower Hotel
Intersur Colon

Intersur Colon

8/10 Good
"."
JOSE LUIS 2-night trip
Posted 12 days ago
Intersur Colon
Howard Johnson by Wyndham San Pedro Resort & Marina

Howard Johnson by Wyndham San Pedro Resort & Marina

10/10 Excellent
"Hemos pasado unos días muy lindos en este lugar, la atención, la limpieza y el spa excelente. Un lugar ideal para darse un gusto."
Vicente Juan José 2-night trip
Posted 2 weeks ago
Howard Johnson by Wyndham San Pedro Resort & Marina
Amérian Hotel Casino Gala

Amérian Hotel Casino Gala

8/10 Good
"El personal muy atento y buena onda, el hotel bien ubicado, grande y con buen servicio. Es un poco antiguo y las instalaciones están un tanto descuidadas, pero en general muy bueno."
Ruth 2-night trip
Posted 2 months ago
Amérian Hotel Casino Gala

More cheap stays in Mesopotamia

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

115 3 de Febrero Gualeguaychú Entre Ríos
￥5,567
￥5,567 total
Sep 14 - Sep 15
7.8/10 Good! (93 reviews)
O2 Hotel Gualeguaychú
hotel san lorenzo design

hotel san lorenzo design

san lorenzo 1138 Corrientes Corrientes Province
￥6,101
￥6,101 total
Sep 15 - Sep 16
4/10 (4 reviews)
hotel san lorenzo design
Bungalows Mexico

Bungalows Mexico

Carlos Granillo Posse N 197 Concepción del Uruguay Entre Rios
￥6,675
￥6,675 total
Sep 17 - Sep 18
Bungalows Mexico
Carat Apart Boutique

Carat Apart Boutique

Montevideo 1552 Rosario Santa Fe
￥15,465
￥15,465 total
Sep 21 - Sep 22
9.6/10 Exceptional! (57 reviews)
Carat Apart Boutique
Hotel Casino Rio Uruguay

Hotel Casino Rio Uruguay

RN117 Paso de los Libres Corrientes
Get rates
10/10 Exceptional! (1 review)
Hotel Casino Rio Uruguay
Pin Up Hostel

Pin Up Hostel

1688 Mitre Rosario Santa Fe
Get ratesPin Up Hostel

Hotels in Mesopotamia with star-rating

Explore a world of travel with Expedia