A marshy landscape with water, trees, and a distant city skyline.

Find all hotels by Best Western in Ladys Island, SC from ¥24,956

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 7 - Sep 8
Tomorrow
Sep 8 - Sep 9
This weekend
Sep 11 - Sep 13
Next weekend
Sep 18 - Sep 20

Our top choices for Ladys Island Best Western

1. Best Western Sea Island Inn

Best Western Sea Island Inn
Historic District
United States
Sharon
¥22,687
¥24,956 total
includes taxes & fees
Sep 14 - Sep 15
Best Western Sea Island Inn
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Ladys Island Hotel Reviews

SpringHill Suites by Marriott Beaufort

SpringHill Suites by Marriott Beaufort

10/10 Excellent
"Staff very friendly and helpful to making your stay enjoyable."
Michelle 3-night trip
Posted 5 hours ago
SpringHill Suites by Marriott Beaufort
Holiday Inn Express Hilton Head Island by IHG

Holiday Inn Express Hilton Head Island by IHG

8/10 Good
"Pretty clean hotel. The bathrooms need actual ventilation but other than that, staff was great, views were good, closeness to the beach was amazing."
Terrance 2-night trip
Posted 6 hours ago
Holiday Inn Express Hilton Head Island by IHG
Tru by Hilton Beaufort, SC

Tru by Hilton Beaufort, SC

10/10 Excellent
"Great overall and thanks"
Raymond 2-night trip
Posted 10 hours ago
Tru by Hilton Beaufort, SC
Montage Palmetto Bluff

Montage Palmetto Bluff

10/10 Excellent
"This weekend was my second visit to the Montage Palmetto. The first time was in February, where all I wanted to do was get a change of scenery from Charleston and do some cycling. That weekend was quiet and calm, and the cycling was superb. This time - the Labor Day weekend - the weather was much warmer, the sunshine was bright, and all the pools were open. The water was refreshing, the bar nearby provided the necessary Negronis, and I was able to play 18 holes at the nearby May River course, complete with a caddie and a full walk. We visited Buffalo's a few times for breakfast and dinner (the staff will golf cart you to and from the hotel) and once at Octagon, which is in the hotel itself. Everything was perfect. I will come back, especially since it's just a 2 hour drive away, and with golfing that rivals - if not beats - Kiawah. Thank you. Christophe"
Christophe 2-night trip
Posted 10 hours ago
Montage Palmetto Bluff
Palmera Inn and Suites

Palmera Inn and Suites

10/10 Excellent
"I loved this property, The pool and hot tub were very clean. The free breakfast was more than adequate. The free coffee available all day was a plus! I had a loft room with king size bed and to be honest it was the most comfortable bed I have ever slept in!! I will definitely be back and would highly recommend this property!"
Anne Marie 3-night trip
Posted 12 hours ago
Palmera Inn and Suites
Holiday Inn Express Bluffton at Hilton Head Area by IHG

Holiday Inn Express Bluffton at Hilton Head Area by IHG

8/10 Good
"Went to check in, for the two nights in a king standard room, and was told they didn't have a king standard and they only had a room available it for one night. Basically "blamed" me for booking thru Expedia. Miraculously after a few minutes we were given the room we booked for the two nights. Facility clean, room clean and located near what we needed."
Jodi 2-night trip
Posted 13 hours ago
Holiday Inn Express Bluffton at Hilton Head Area by IHG
Beach House Resort Hilton Head

Beach House Resort Hilton Head

10/10 Excellent
"We love coming here do to the fact that everything is right there, the beach, the shopping, food and entertainment. This is our second stay and we will be back again. One thing I don’t understand is why we have to pay a daily $15 parking fee to park on the property parking lot and why I had to pay all these fees everyday of the stay! Other than that we enjoy it."
Charles 4-night trip
Posted 16 hours ago
Beach House Resort Hilton Head
Beaufort Inn

Beaufort Inn

10/10 Excellent
"Excellent location for walking to shops and food!"
Steven 2-night trip
Posted 1 day ago
Beaufort Inn
Spark By Hilton Hilton Head Island

Spark By Hilton Hilton Head Island

8/10 Good
"Great place for a vacation"
Yatasha 1-night trip
Posted 2 days ago
Spark By Hilton Hilton Head Island

Explore a world of travel with Expedia