La Mesa Vacation Rentals from ￥18,164: Search Short-Term Rentals

Q: What's the top vacation rental in La Mesa?

Moon House River Dreams Cerro Azul : You might want to consider this vacation home rental near La Mesa, which is located on a river and has a garden, a barbecue grill, and laundry facilities to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. You and your friends and family can relax into your vacation with amenities like a selection of books.

Check prices for these dates

In two weeks

In two months

In three months

In four months

Our top choices for La Mesa vacation rentals

Apartment, 1 Bedroom, Balcony | Interior

1. Swette Love 10 Minutes From the Airport Tocumen

Las Mañanitas

￥11,825 total

includes taxes & fees

Aug 9 - Aug 10

2. Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

kenron

￥24,725 total

includes taxes & fees

Aug 18 - Aug 19

3. Apex Executive Apartments - Dovle

Parque Lefevre

￥33,440 total

includes taxes & fees

Aug 12 - Aug 13

4. Citylodge 1br Apt Near Balboa Academy

San Francisco

￥24,856 total

includes taxes & fees

Aug 12 - Aug 13

5. Dovle Residences by HMS-Preferred Member

San Francisco

Ani

￥23,126 total

includes taxes & fees

Sep 6 - Sep 7

Apartment, 3 Bedrooms | Living area | 32-inch Smart TV with digital channels, TV, Netflix

6. Boutique Apartments Panamá Coco del Mar

San Francisco

Hugo

￥28,181 total

includes taxes & fees

Aug 23 - Aug 24

7. Boutique Apartments Atlapa

San Francisco

Dustin M

￥22,391 total

includes taxes & fees

Aug 16 - Aug 17

8. Modern Apartments at the Hub City views

San Francisco

￥18,164 total

includes taxes & fees

Aug 19 - Aug 20

9. San Francisco by Wynwood House

San Francisco

Claire

￥25,551 total

includes taxes & fees

Aug 9 - Aug 10

10. Modern Apartments PH Living 73 SF

San Francisco

Dawid

Apartment, 3 Bedrooms, Accessible, Pool View | Interior

11. Charming 3 Bedroom Apartment in San Miguelito, Panama City

José Domingo Espinar

caleb

￥15,423 total

includes taxes & fees

Aug 13 - Aug 14

12. Living 73 Panamá by Boutique Apartments

San Francisco

"Review checkin process. Find entry codes and details about key fobs. Find out if there is construction next door as i was awaken every morning at 7am by construction noise. Verify everything works upon entry and request immediate fix. I was without internet for a day and had to wait various days for repairmen to come fix things without having a set time for their visit. Great place to stay. Walking distance of many things and great amenities but had some minor inconveniences. Staff was very...

Will

￥31,298 total

includes taxes & fees

Aug 23 - Aug 24

Chalet, Balcony, Mountain View | Exterior

13. Tiny Cabin

Panamá

￥23,180 total

includes taxes & fees

Aug 12 - Aug 13

14. Fully Equipped 1br Apartment Panama City

San Francisco

￥24,856 total

includes taxes & fees

Aug 12 - Aug 13

15. Luxury Panama City Studio Pool Gym Views

San Francisco

￥24,332 total

includes taxes & fees

Sep 6 - Sep 7

16. Minimalist 1br With Modern Decor

San Francisco

￥23,922 total

includes taxes & fees

Aug 9 - Aug 10

17. Relaxing 2br Apt at Coco del mar

San Francisco

￥28,810 total

includes taxes & fees

Aug 12 - Aug 13

18. Apartment for 3 in Panama With Pool and gym

San Francisco

￥29,008 total

includes taxes & fees

Sep 4 - Sep 5

19. Fresh Living 1br Apt Near Coral Area

San Francisco

￥24,856 total

includes taxes & fees

Aug 12 - Aug 13

20. Lovely 2br Apt Close to Shops

San Francisco

￥28,810 total

includes taxes & fees

Aug 12 - Aug 13

View all properties

Find vacation rentals that suit your style

Aparthotels

Apartments

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Top La Mesa Hotel Reviews

Crowne Plaza Panama Airport by IHG

10/10 Excellent

"All is good"

Express Inn Panama International Airport Hostel

8/10 Good

"The floors in my room did not look clean. Blanket had stains on it. No mini fridge in the room. AC worked well but when you arrive you have to turn it on yourself. Check in was fine check out the lady was too busy on her own personal call. Any question I got was a nod of her head. Was fine for a quick overnight sleep/layover"

Corporate Stays Arcadia | Executive Furnished Apartments

8/10 Good

"My wife and I stayed here for five days in late June 2026, and overall we had a great experience. The building and apartment are modern, clean, and spacious. The location is excellent, with grocery stores, restaurants, shops, and the mall all nearby. The lobby smells so good you'll probably wish your house smelled the same way. Check-in was quick and easy, and everyone we met was friendly and welcoming. The apartment had two full bathrooms, which was a nice bonus for just the two of us. Having a washer and dryer in the unit was incredibly convenient. The rooftop pool was fantastic, the views were beautiful, and the building felt very secure with multiple locks on the doors. It's also only about a 10-minute drive from the airport. The biggest thing to know is that this isn't a traditional hotel. It's an apartment building, so you're more self-sufficient. If you need extra towels or toilet paper, it's not as simple as calling the front desk. We also would have appreciated better instructions about things like where to take the trash. After five days, the floors got dirty, but there wasn't a broom or stick vacuum for a quick cleanup. The shower water never got more than lukewarm. The kitchen had dishes, pots, and pans, but no food storage containers, so we made a quick trip to buy Ziplock bags for leftovers. Would we stay again? Absolutely. The price, location, and overall value were excellent. Now that we know what to expect, we'd definitely book it again."

Find out more about La Mesa

Search for holiday rentals in La Mesa on Expedia! You can easily find your home rentals, villas, holiday apartments in La Mesa using one of the methods below:

View our selection of featured holiday rentals in La Mesa
Use the map to find apartments and other holiday homes in the La Mesa neighbourhood you prefer
Enter your travel dates to view the best deals on holiday rentals in La Mesa while they last

Look no further and take a look at our great range of rental properties in La Mesa!

Frequently asked questions

Are there vacation rentals in La Mesa?

Yes, we offer vacation rentals close to well known sights in La Mesa, or you can choose a more secluded option if you're looking for a relaxing stay.

What's the top vacation rental in La Mesa?

Moon House River Dreams Cerro Azul: You might want to consider this vacation home rental near La Mesa, which is located on a river and has a garden, a barbecue grill, and laundry facilities to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. You and your friends and family can relax into your vacation with amenities like a selection of books.

What’s there to see and do in La Mesa?

While exploring the area, visit family-friendly sights like Chepo Youth Recreation Center, or get outside and enjoy nature at Chagres National Park. In the larger area, you’ll find Metromall Panama and Los Pueblos Commercial Center.

What’s a vacation rental in La Mesa like?

A vacation rental is a private property you can stay in for short or long periods in La Mesa. Vacation rentals feature amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about a sanitized environment, vacation rentals can offer a sense of security away from public hotel elevators and busy concierge desks while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a popular option for family trips or small group gatherings.

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for La Mesa vacation rentals

1. Swette Love 10 Minutes From the Airport Tocumen

2. Corporate Stays Arcadia | Executive Furnished Apartments

3. Apex Executive Apartments - Dovle

4. Citylodge 1br Apt Near Balboa Academy

5. Dovle Residences by HMS-Preferred Member

6. Boutique Apartments Panamá Coco del Mar

7. Boutique Apartments Atlapa

8. Modern Apartments at the Hub City views

9. San Francisco by Wynwood House

10. Modern Apartments PH Living 73 SF

11. Charming 3 Bedroom Apartment in San Miguelito, Panama City

12. Living 73 Panamá by Boutique Apartments

13. Tiny Cabin

14. Fully Equipped 1br Apartment Panama City

15. Luxury Panama City Studio Pool Gym Views

16. Minimalist 1br With Modern Decor

17. Relaxing 2br Apt at Coco del mar

18. Apartment for 3 in Panama With Pool and gym

19. Fresh Living 1br Apt Near Coral Area

20. Lovely 2br Apt Close to Shops

Find vacation rentals that suit your style

Top La Mesa Hotel Reviews

Crowne Plaza Panama Airport by IHG

Ramada Plaza by Wyndham Panama Punta Pacifica

Express Inn Panama International Airport Hostel

Dovle Residences by HMS-Preferred Member

Aloft by Marriott Panama

ORHO Hotel Boutique 15 Minutes from PTY Airport

Corporate Stays Arcadia | Executive Furnished Apartments

Boutique Apartments Panamá Coco del Mar

Sheraton Grand Panama

Find out more about La Mesa

Frequently asked questions

Go further with the Expedia app