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Our top choices for La Jolla Mesa hotels

Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
14.2 km from La Jolla Mesa
8.6 out of 10, Excellent, (1471)
"I loved my stay here"
United States
José
The Bristol Hotel San Diego
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
15.1 km from La Jolla Mesa
9.0 out of 10, Wonderful, (1175)
"Amenities and location were great. "
United States
Julie
The price is ￥26,633
￥37,233 total
includes taxes & fees
Dec 29 - Dec 30
Margaritaville Hotel San Diego Gaslamp Quarter
Deluxe Room, 2 Queen Beds | Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
14.5 km from La Jolla Mesa
9.0 out of 10, Wonderful, (2880)
"Everything was great and so convenient to everywhere we wanted to go to"
United States
Julio J
The price is ￥27,556
￥40,480 total
includes taxes & fees
Dec 29 - Dec 30
Manchester Grand Hyatt San Diego
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
15.1 km from La Jolla Mesa
9.0 out of 10, Wonderful, (1240)
"Clean, courteous staff, good location. "
United States
Carla
The price is ￥15,500
￥17,971 total
includes taxes & fees
Dec 29 - Dec 30
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Exterior
La Pensione Hotel

La Pensione Hotel

La Pensione Hotel
3.0 star property
13.4 km from La Jolla Mesa
8.6 out of 10, Excellent, (1889)
"Great check-in experience, convenient parking, the room was clean and bed was comfortable. The city view option was exceptionally pleasant. Will stay again! "
United States
Mike
The price is ￥20,996
￥23,883 total
includes taxes & fees
Dec 29 - Dec 30
La Pensione Hotel
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
13.6 km from La Jolla Mesa
9.0 out of 10, Wonderful, (142)
"Great place to stay "
United States
Jacorey
The price is ￥19,102
￥22,148 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott San Diego Downtown Little Italy
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
3.5 star property
14.9 km from La Jolla Mesa
9.0 out of 10, Wonderful, (2710)
"Beautiful hotel, far surpasses any expectation of an older Victorian hotel. I highly recommend this stay! "
United States
Jessica
The price is ￥19,668
￥27,038 total
includes taxes & fees
Dec 29 - Dec 30
The Horton Grand, Downtown/Gaslamp Quarter
View from property
Pacific View Inn

Pacific View Inn

Pacific View Inn
2.0 star property
2.2 km from La Jolla Mesa
8.0 out of 10, Very Good, (1003)
"Perfect location, clean room and the staff was very nice. "
United States
Tunde
The price is ￥17,586
￥19,863 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Pacific View Inn
Front of property
The Sofia Hotel

The Sofia Hotel

The Sofia Hotel
3.5 star property
14.2 km from La Jolla Mesa
8.4 out of 10, Very Good, (1667)
"Great location and history to the hotel "
United States
Stephanie
The price is ￥18,592
￥25,283 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Sofia Hotel
2 outdoor pools, a heated pool, sun loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
6 km from La Jolla Mesa
9.0 out of 10, Wonderful, (3937)
"Always love staying here. Staff was very courteous and the rooms very clean. "
United States
Eric
The price is ￥21,763
￥28,147 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Dana on Mission Bay
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
15 km from La Jolla Mesa
9.4 out of 10, Exceptional, (1006)
"Great location "
United States
Mohammad
The price is ￥13,485
￥20,161 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
13.5 km from La Jolla Mesa
8.4 out of 10, Very Good, (6039)
"Always an amazing stay"
United States
Jana
The price is ￥21,160
￥29,076 total
includes taxes & fees
Dec 30 - Dec 31
Wyndham San Diego Bayside
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
13.7 km from La Jolla Mesa
8.8 out of 10, Excellent, (804)
"would stay again and recommend "
United States
Brendi
The price is ￥16,283
￥18,879 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The DEXTRO Little Italy, BW Premier Collection
Property grounds
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
5 km from La Jolla Mesa
8.6 out of 10, Excellent, (2358)
"A very unexpected surprise place for vacation! We truly enjoyed the resort, it reminds us of Hawaii! Just a great place and we highly recommend it!"
United States
Ralitza
The price is ￥20,252
￥31,564 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Paradise Point Resort & Spa
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
14.3 km from La Jolla Mesa
9.0 out of 10, Wonderful, (1557)
"Perfect location , friendly staff , good buffet"
United States
Patricio
The price is ￥26,833
￥36,791 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Embassy Suites by Hilton San Diego Bay Downtown
Outdoor pool, sun loungers
Inn By The Sea La Jolla

Inn By The Sea La Jolla

Inn By The Sea La Jolla
3.5 star property
Village of La Jolla, 3.6 km from La Jolla Mesa
9.4 out of 10, Exceptional, (1755)
"The room was great, staff was nice and helpful. The area is AWESOME for a weekend getaway"
United States
Durran
The price is ￥24,942
￥28,670 total
includes taxes & fees
Dec 29 - Dec 30
Inn By The Sea La Jolla
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
14.6 km from La Jolla Mesa
9.0 out of 10, Wonderful, (1019)
"Great hotel, excellent location, excellent view on rooftop!"
United States
Rajeev
The price is ￥18,475
￥21,015 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Gaslamp Plaza Suites
Outdoor pool, a heated pool
The Wayfarer San Diego

The Wayfarer San Diego

The Wayfarer San Diego
4.0 star property
3.1 km from La Jolla Mesa
9.4 out of 10, Exceptional, (1727)
"Great room, clean and updated property, exceptional service, perfect location. Loved our stay and can't wait to return. "
United States
Michelle
The price is ￥29,239
￥33,609 total
includes taxes & fees
Jan 8 - Jan 9, 2026
The Wayfarer San Diego
Beach nearby, scuba diving
PB Surf Beachside Inn

PB Surf Beachside Inn

PB Surf Beachside Inn
2.5 star property
2 km from La Jolla Mesa
8.2 out of 10, Very Good, (1002)
"Really nice place to stay at"
United States
Alejandro
The price is ￥13,950
￥15,756 total
includes taxes & fees
Jan 6 - Jan 7, 2026
PB Surf Beachside Inn
Outdoor pool, sun loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
15.5 km from La Jolla Mesa
8.6 out of 10, Excellent, (1895)
"Enjoyed my stay"
United States
Brandon
The price is ￥18,807
￥29,481 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton San Diego Bayfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in La Jolla Mesa

Find the best La Jolla Mesa areas and neighborhoods for the activities you enjoy most.
Birch Aquarium showing marine life and interior views

La Jolla Shores

If you're spending some time in La Jolla Shores, La Jolla Beach and Birch Aquarium are top sights worth seeing.

La Jolla Cove which includes rugged coastline and general coastal views as well as a small group of people

Village of La Jolla

Seaside community offering scuba diving, surfing, and picturesque beaches like La Jolla Cove. Explore Mount Soledad, Museum of Contemporary Art, and indulge in upmarket dining and shopping along Prospect Street and Girard Avenue.

Torrey Pines

Boasting the highly-ranked Torrey Pines Golf Course, this coastal neighborhood offers 42% parks and open spaces, with easy access to I-5. Explore nearby Torrey Pines State Park and beach for stunning ocean views.

Country Club

While Country Club might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like La Jolla Cove and Mount Soledad National Veterans Memorial.

La Jolla

Beach Barber Tract

While visiting Beach Barber Tract, you might make a stop by sights like Windansea Beach and Marine Street Beach.

Top La Jolla Mesa Hotel Reviews

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

10/10 Excellent
"Did not do the breakfast "
Karl 1-night trip
Posted 10 hours ago
Hard Rock Hotel San Diego

Frequently asked questions

What is La Jolla Mesa like?
Travelers to La Jolla's La Jolla Mesa neighborhood will be sure to enjoy a stay in this neighborhood.
How many hotels can I expect to find in the La Jolla Mesa area?
If you're searching for places to stay in La Jolla, choose from one of Expedia's 15 hotels and other accommodations in La Jolla Mesa.
If I need to cancel my hotel reservation in La Jolla Mesa, will I receive a refund?
Yes, the majority of hotel reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get the best deals in La Jolla Mesa.
Where can I learn more about changing or cancelling my trip to La Jolla Mesa?
For more information about updating your trip to La Jolla Mesa or cancelling it, head over to our customer service page.
What are the top things to see and do in La Jolla Mesa?
Tourmaline Surfing Park, Bird Rock, and Pacific Beach are just a few of the places to visit in and around La Jolla Mesa. While you're out sightseeing, Mount Soledad National Veterans Memorial and Windansea Beach are a couple of additional sights to visit in La Jolla.