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Compare 3,787 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Algila' Ortigia Charme Hotel

4.0 star property
Ortigia
9.6 out of 10, Exceptional, (905)
"The breakfast was delicious, the staff impeccable and the room delightful. All in all an excellent stay which I would wholeheartedly recommend. "
United Kingdom
Sarah
Algila' Ortigia Charme Hotel

Ortea Palace Hotel, Sicily, Autograph Collection

5.0 star property
Ortigia
9.4 out of 10, Exceptional, (250)
"Great location and very friendly staff"
United States
James
The price is ¥34,063
¥39,277 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Ortea Palace Hotel, Sicily, Autograph Collection

Domus Mariae Albergo

3.0 star property
Ortigia
9.2 out of 10, Wonderful, (341)
"Lovely staff and unbeatable location! "
United Kingdom
Grace Foggo
The price is ¥22,116
¥25,212 total
includes taxes & fees
Dec 9 - Dec 10
Domus Mariae Albergo

Grand Hotel Ortigia Siracusa

5.0 star property
Ortigia
9.0 out of 10, Wonderful, (570)
"Great stay!"
United States
Liza
The price is ¥29,710
¥34,489 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Grand Hotel Ortigia Siracusa

Charme Hotel Henry's House

4.0 star property
Ortigia
9.6 out of 10, Exceptional, (322)
"Great location. Very friendly and helpful staff. Nice breakfast."
United States
Alan
The price is ¥43,192
¥49,319 total
includes taxes & fees
Dec 27 - Dec 28
Charme Hotel Henry's House

Palazzo Artemide - VRetreats, SLH Collection

4.0 star property
Ortigia
9.4 out of 10, Exceptional, (659)
"Great hotel"
United States
Caterina
The price is ¥33,329
¥38,470 total
includes taxes & fees
Dec 19 - Dec 20
Palazzo Artemide - VRetreats, SLH Collection

Dimore delle Zagare Ortigia

Ortigia
9.8 out of 10, Exceptional, (160)
"It was a perfect location"
United States
Susan
Dimore delle Zagare Ortigia

BeBIgea Rooms

Syracuse
9.2 out of 10, Wonderful, (13)
"Simple stay for a weekend getaway "
United States
Misty
BeBIgea Rooms

Hotel Parco delle Fontane

4.0 star property
Tiche
9.2 out of 10, Wonderful, (281)
"Pool was excellent and the surrounding gardens superb "
United States
ROBERT
The price is ¥16,620
¥18,948 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hotel Parco delle Fontane

Maniace Boutique Hotel Ortigia UNA Esperienze

Ortigia
9.8 out of 10, Exceptional, (56)
"Wonderful boutique hotel across from the ocean. The employees are very helpful and gracious. "
United States
Beth
The price is ¥29,546
¥34,309 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Maniace Boutique Hotel Ortigia UNA Esperienze

Palazzo Salomone

3.0 star property
Ortigia
9.2 out of 10, Wonderful, (19)
"Very nice hotel. "
Canada
Mark
The price is ¥16,276
¥18,554 total
includes taxes & fees
Dec 9 - Dec 10
Palazzo Salomone

Lanterne Magiche Ortigia

Ortigia
9.4 out of 10, Exceptional, (182)
"Staff was wonderful, breakfast was superior."
United States
Joyce
Lanterne Magiche Ortigia

Eureka Palace Hotel Spa Resort

4.0 star property
Syracuse
8.0 out of 10, Very Good, (323)
"We stayed here for one night and wish we could have stayed longer. We didn’t have time to use the spa but we did go to the outdoor pool for a bit. The pool was amazing and the outdoor bar was a nice touch. The breakfast was very good and the room overlooked the race track so you can watch the horses warm up in the morning. It was an overall excellent hotel for the price. "
United States
Carol
Eureka Palace Hotel Spa Resort

Grand Hotel Villa Politi

4.0 star property
Grottasanta
8.6 out of 10, Excellent, (941)
"Wonderful hotel, nice area and great buffet breakfast"
United States
paula
The price is ¥15,419
¥17,578 total
includes taxes & fees
Dec 9 - Dec 10
Grand Hotel Villa Politi

I Santi Coronati Bed & Breakfast

Ortigia
8.8 out of 10, Excellent, (26)
"Everything was great "
United States
pierfranco
I Santi Coronati Bed & Breakfast

Lanterne Magiche Ortigia Suites

Ortigia
9.4 out of 10, Exceptional, (13)
"It's just a great place."
Canada
Philippe
Lanterne Magiche Ortigia Suites

Hotel Palazzo Cavalieri

4.0 star property
Santa Lucia
8.8 out of 10, Excellent, (38)
"The location of this hotel is ideal! Directly between the train station and Ortigia. Easy walking to many different restaurants. We very much enjoyed our short stay here and the daily activities hosted by the Hotel. My only iffy thing was the tiles in the bathroom (the shower specifically) seemed a bit older and maybe not as cleanly as it could be, but all in all the room was quite nice. "
Canada
Lindsay
The price is ¥15,764
¥17,971 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Palazzo Cavalieri

Palazzo Russo Ortigia Suite & Apartments

Ortigia
10.0 out of 10, Exceptional, (2)
"The staffs hospitality was unmatched here. My wife and I had an amazing time. The restaurant food was unbelievable as well! Would highly recommend this hotel! "
Canada
Scott
The price is ¥24,459
¥27,883 total
includes taxes & fees
Dec 14 - Dec 15
Palazzo Russo Ortigia Suite & Apartments

Hotel Posta

3.0 star property
Ortigia
8.4 out of 10, Very Good, (453)
"Hotel Posta is the perfect small hotel in a great location. If you have a car the public parking is steps away, walking around is a breeze. So many great restaurants. My room was perfect, roof top terrace, breakfast and a very friendly staff. "
United States
Jacquelin
The price is ¥15,758
¥17,965 total
includes taxes & fees
Dec 9 - Dec 10
Hotel Posta

Tramonto Ibleo Resort

Avola
8.8 out of 10, Excellent, (22)
"There was a big party the first night and hard to sleep. But the hotel is nice and clean "
United Kingdom
Ragnar
The price is ¥14,942
¥17,159 total
includes taxes & fees
Dec 14 - Dec 15
Tramonto Ibleo Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Isola attractions

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Frequently asked questions

What's the best place for a stay in Isola?
Located 2.1 mi (3.5 km) from the heart of Isola, Algila' Ortigia Charme Hotel is a top choice for your stay based on our traveler data. Two other choices for your visit to the area are Grand Hotel Villa Politi and Eureka Palace Hotel Spa Resort. See all available top hotels, or vacation rentals in Isola.
What are some of the best vacation rentals that Isola has to offer?
Sicilian farmhouse from the 19th Century - close to the beach and with a large pool: Visitors give good reviews to this Isola vacation home rental, which is located in the mountains and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and kitchenware. Another good choice for your trip to Isola is House with private tennis court, pool, 300m to the beach, WiFi, air conditioning. See all vacation rentals in Isola.
If I need to cancel my hotel reservation in Isola, will I receive a refund?
Yes, most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Isola.
Where can I learn more about changing or cancelling my trip to Isola?
For additional details about rescheduling or cancelling your trip to Isola, go to https://www.expedia.com/service/.
What are some hotels with pools in Isola?
Grand Hotel Villa Politi: Provides a rooftop terrace, a seasonal outdoor pool, and buffet. House with private tennis court, pool, 300m to the beach, WiFi, air conditioning and Eureka Palace Hotel Spa Resort are a couple of other choices with an onsite pool. View all hotels with pools in Isola.
How is it to stay in Isola?
Those traveling to Isola are sure to enjoy the sights to see and things to do. In Isola, there are 14 hotels and other accommodations to choose from. Find out more about Isola.
What should I see while I'm in Isola?
The picturesque setting of Ionian Sea and Spiaggia Punta del Pero exemplify the area's natural beauty. You'll also find Castello Maniace and Tropical Aquarium of Syracuse in the area. Check out what more to see and do in Expedia's Isola guide.
What's the weather like in Isola?
The hottest months are usually August and July with an average temp of 78°F, while the coldest months are February and January with an average of 56°F. Average annual precipitation for Isola is 26 inches.

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