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Our top choices for Esquilino luxury hotels

An outdoor dining area with wicker chairs and a round table, overlooking a historic stone wall and buildings in the background.

1. NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1,002 reviews)
  • cleanliness
    Luxury redefined at this 5-star Rome hotel with rooftop terrace, garden-view dining, and plush rooms steps from Termini Station.
The price is ￥50,778
￥59,401 total
includes taxes & fees
Nov 8 - Nov 9
NH Collection Roma Palazzo Cinquecento
A grand hallway with marble flooring, a red carpet, and a chandelier.

2. BQ HOUSE COLOSSEUM 2Luxury Rooms

BQ HOUSE COLOSSEUM 2Luxury Rooms
Rome City Centre
8.4 out of 10, Very good, (29 reviews)
The price is ￥36,753
￥42,556 total
includes taxes & fees
Nov 9 - Nov 10
BQ HOUSE COLOSSEUM 2Luxury Rooms
A large, ornate wooden door with a metal grille above it, set within a classical architectural style with detailed moldings and a stone facade.

3. Vacanze Romane Laterano

Vacanze Romane Laterano
Rome Historic Centre
9.8 out of 10, Exceptional, (8 reviews)
The price is ￥45,547
￥57,549 total
includes taxes & fees
Oct 18 - Oct 19
Vacanze Romane Laterano
Terrace/patio

4. Vanella Rome Domus

Vanella Rome Domus
Rome City Centre
8.0 out of 10, Very good, (53 reviews)
The price is ￥33,222
￥38,318 total
includes taxes & fees
Oct 22 - Oct 23
Vanella Rome Domus
A modern bedroom with a large bed, a bedside table with a lamp, a small potted plant, and a view of the outdoors through a window with sheer curtains.

5. Suite Inn Rome

Suite Inn Rome
Rome City Centre
8.6 out of 10, Excellent, (65 reviews)
The price is ￥23,906
￥28,424 total
includes taxes & fees
Nov 8 - Nov 9
Suite Inn Rome
A table with a tray containing a mug, a book, a glass of orange juice, and a small container of snacks.

6. Rhome GuestHouse

Rhome GuestHouse
Rome City Centre
9.4 out of 10, Exceptional, (42 reviews)
The price is ￥29,302
￥34,714 total
includes taxes & fees
Nov 3 - Nov 4
Rhome GuestHouse
A modern kitchen with white cabinets, a built-in washing machine, a black sink, and a marble countertop.

7. Rhome Sweet Rhome Apt

Rhome Sweet Rhome Apt
Rome City Centre
8.0 out of 10, Very good, (6 reviews)
Rhome Sweet Rhome Apt
A courtyard with a brick structure, lush greenery, and a building with shutters in the background.

8. De Vince Luxury Suites - Roma Termini

De Vince Luxury Suites - Roma Termini
Rome City Centre
7.6 out of 10, Good, (14 reviews)
De Vince Luxury Suites - Roma Termini
A modern hotel room with a large bed, a bedside table, a mirror, and a bench.

9. Domus Domas & Boutique

Domus Domas & Boutique
Rome City Centre
7.0 out of 10, Good, (50 reviews)
The price is ￥21,117
￥25,357 total
includes taxes & fees
Nov 3 - Nov 4
Domus Domas & Boutique
A view through a window with curtains, revealing a street scene with buildings and parked cars.

10. White King Rooms

White King Rooms
Rome Historic Centre
8.8 out of 10, Excellent, (9 reviews)
The price is ￥17,820
￥21,730 total
includes taxes & fees
Nov 11 - Nov 12
White King Rooms
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Esquilino Hotel Reviews

NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

10/10 Excellent
"This hotel is absolutely stunning, but what truly makes it special is the staff. They were some of the kindest, warmest, and most attentive people we encountered during our entire trip. Every interaction was exceptional, we cannot say enough good things about them. We were pleasantly surprised with a complimentary suite upgrade, and upon arrival found a beautiful bottle of chilled wine and a handwritten note waiting for us. It was such a thoughtful touch and set the tone for our stay. The complimentary breakfast was absolutely fabulous, with a wide variety of delicious options each morning. We also enjoyed dinner at the rooftop restaurant, which was beautiful with wonderful ambiance and a great overall experience. The location was great, right by the bus hub, Hop-On Hop-Off bus stop, and all the shops and restaurants inside Roma Termini. My only caution is that "steps from the train station" is a bit misleading. While the hotel is close to the station entrance, Roma Termini is enormous!! After arriving from the Civitavecchia cruise port, the walk from our train platform to the hotel with luggage was much longer than expected and included rough cobblestone streets. The train itself was inexpensive and convenient, but on a Monday morning it was packed with commuters and there were no seats available. That said, I would absolutely stay here again. The beautiful hotel was wonderful, but it was the incredible staff and their genuine hospitality that made this stay so memorable."
Amber 1-night trip
Posted 16 hours ago
NH Collection Roma Palazzo Cinquecento

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Esquilino?
Arrange a flight into Ciampino Airport (CIA) Airport or Fiumicino - Leonardo da Vinci Intl. Airport (FCO) Airport, and then treat yourself to a stay at one of 17 luxurious hotels. During your visit, you might want to enjoy the sightseeing and museums which Esquilino is known for.
What's the best high-end place to stay in Esquilino?
NH Collection Roma Palazzo Cinquecento is a luxury hotel with a rooftop terrace and a deli, and it's a popular choice for Expedia travelers looking for an elegant place to stay. BQ HOUSE COLOSSEUM 2Luxury Rooms and Le terrazze di San Giovanni are two other upscale options for your vacation.
How many luxury hotels will I find in Esquilino?
Lie in the lap of luxury during your getaway to Esquilino in one of Expedia's 17 luxury hotels.
What's there to see and do in Esquilino?
Enjoy all that Esquilino has to offer when you visit Piazza Vittorio Emanuele II, Piazza Santa Maria Maggiore, and Basilica di Santa Croce in Gerusalemme. If you have a bit of extra time while you're in the area, you might want to check out Via Marsala and Teatro Ambra Jovinelli.
How can I get around Esquilino?
It's easier to get around town comfortably when you know your options. You can access metro transit at S Bibiana Station, Vittorio Emanuele Station, and Manzoni - Museo della Liberazione Station.

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