Two men sitting on a bench in a park, reading newspapers.

Find Luxury Hotels in Esquilino

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Esquilino Luxury Hotels

Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Our top choices for Esquilino luxury hotels

An outdoor dining area with wicker chairs and a round table, overlooking a historic stone wall and buildings in the background.

1. NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento
5.0 star property
Rome City Centre
9.0 out of 10, Wonderful, (1,004 reviews)
  • cleanliness
    Luxury redefined at this 5-star Rome hotel with rooftop terrace, garden-view dining, and plush rooms steps from Termini Station.
The price is ￥59,597
￥69,110 total
includes taxes & fees
Nov 1 - Nov 2
NH Collection Roma Palazzo Cinquecento
A grand hallway with marble flooring, a red carpet, and a chandelier.

2. BQ HOUSE COLOSSEUM 2Luxury Rooms

BQ HOUSE COLOSSEUM 2Luxury Rooms
Rome City Centre
8.4 out of 10, Very good, (28 reviews)
The price is ￥62,064
￥70,402 total
includes taxes & fees
Nov 3 - Nov 4
BQ HOUSE COLOSSEUM 2Luxury Rooms
A modern bedroom with a large bed, a bedside table with a lamp, a small potted plant, and a view of the outdoors through a window with sheer curtains.

3. Suite Inn Rome

Suite Inn Rome
Rome City Centre
8.6 out of 10, Excellent, (65 reviews)
The price is ￥28,999
￥34,031 total
includes taxes & fees
Nov 2 - Nov 3
Suite Inn Rome
A table with a tray containing a mug, a book, a glass of orange juice, and a small container of snacks.

4. Rhome GuestHouse

Rhome GuestHouse
Rome City Centre
9.4 out of 10, Exceptional, (42 reviews)
The price is ￥30,018
￥35,507 total
includes taxes & fees
Nov 3 - Nov 4
Rhome GuestHouse
Terrace/patio

5. Vanella Rome Domus

Vanella Rome Domus
Rome City Centre
8.0 out of 10, Very good, (52 reviews)
The price is ￥33,286
￥38,392 total
includes taxes & fees
Oct 27 - Oct 28
Vanella Rome Domus
A courtyard with a brick structure, lush greenery, and a building with shutters in the background.

6. De Vince Luxury Suites - Roma Termini

De Vince Luxury Suites - Roma Termini
Rome City Centre
7.6 out of 10, Good, (14 reviews)
De Vince Luxury Suites - Roma Termini
A window with a view of a historic building with a tower and a statue in the foreground.

7. Madonna della Neve

Madonna della Neve
Rome City Centre
8.4 out of 10, Very good, (16 reviews)
The price is ￥26,649
￥31,801 total
includes taxes & fees
Oct 11 - Oct 12
Madonna della Neve
A modern bedroom with a large bed, a desk, and a view of the outdoors through a sliding glass door.

8. Savoia Rooms Roma

Savoia Rooms Roma
Rome Historic Centre
9.4 out of 10, Exceptional, (8 reviews)
The price is ￥15,140
￥18,786 total
includes taxes & fees
Nov 2 - Nov 3
Savoia Rooms Roma
A view through a window with curtains, revealing a street scene with buildings and parked cars.

9. White King Rooms

White King Rooms
Rome Historic Centre
8.6 out of 10, Excellent, (8 reviews)
The price is ￥15,392
￥19,063 total
includes taxes & fees
Nov 3 - Nov 4
White King Rooms
A modern gym with various exercise equipment, a large mirror, and a television.

10. Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World

Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World
5.0 star property
Rome City Centre
9.2 out of 10, Wonderful, (1,002 reviews)
  • cleanliness
    Indulge in ultimate relaxation at this five-star Roman haven featuring a full-service spa, seasonal pool, and elegant dining options.
The price is ￥101,072
￥114,732 total
includes taxes & fees
Nov 3 - Nov 4
Anantara Palazzo Naiadi Rome Hotel - A Leading Hotel of the World
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Esquilino Hotel Reviews

Mecenate Palace

Mecenate Palace

8/10 Good
"The location is what I like best. Close to transit, a supermarket opposite the street, and several restaurants just a few steps away, including a decent Chinese restaurant that charges 10€ for a meat dish. It's also walking distance to several nice churches and the Colosseum. The details of the hotel are nice but kind of old. The rooftop terrace is nice, with a great view of the church opposite the hotel. We had dinner there at the rooftop restaurant. The food was only ok but the sunset view was very nice."
Joseph 3-night trip
Posted 1 hour ago
Mecenate Palace

Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Esquilino?
Arrange a flight into Ciampino Airport (CIA) Airport or Fiumicino - Leonardo da Vinci Intl. Airport (FCO) Airport, and then treat yourself to a stay at one of 17 luxurious hotels. During your visit, you might want to enjoy the sightseeing and museums which Esquilino is known for.
What's the best high-end place to stay in Esquilino?
NH Collection Roma Palazzo Cinquecento is a luxury hotel with a rooftop terrace and a deli, and it's a popular choice for Expedia travelers looking for an elegant place to stay. BQ HOUSE COLOSSEUM 2Luxury Rooms and Le terrazze di San Giovanni are two other upscale options for your vacation.
How many luxury hotels will I find in Esquilino?
Lie in the lap of luxury during your getaway to Esquilino in one of Expedia's 17 luxury hotels.
What's there to see and do in Esquilino?
Enjoy all that Esquilino has to offer when you visit Piazza Vittorio Emanuele II, Piazza Santa Maria Maggiore, and Basilica di Santa Croce in Gerusalemme. If you have a bit of extra time while you're in the area, you might want to check out Via Marsala and Teatro Ambra Jovinelli.
How can I get around Esquilino?
It's easier to get around town comfortably when you know your options. You can access metro transit at S Bibiana Station, Vittorio Emanuele Station, and Manzoni - Museo della Liberazione Station.

Explore a world of travel with Expedia