A cityscape with historic buildings, a baseball field, a pedestrian street, and modern architecture.

Find Resorts & Hotels with Spas in Durham, NC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Durham Resorts & Hotels with Spas

This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Our top choices for Durham hotels with a spa

Restaurant

1. 21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham
8.4 out of 10, Very good, (1,018 reviews)
  • cleanliness
    Rejuvenate at this upscale hotel with spa treatment rooms and a sauna near Durham's arts district.
The price is ￥22,664
￥26,513 total
includes taxes & fees
Nov 22 - Nov 23
21c Museum Hotel Durham
A lobby with a central round table surrounded by armchairs, a chandelier, and a floral arrangement.

2. The Umstead Hotel and Spa

The Umstead Hotel and Spa
5.0 star property
Cary
9.6 out of 10, Exceptional, (848 reviews)
  • cleanliness
    Discover a spa sanctuary where deep soaking tubs and rejuvenating treatments await in this immaculate luxury resort.
The price is ￥60,656
￥68,692 total
includes taxes & fees
Nov 15 - Nov 16
The Umstead Hotel and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Choose what matters most at spa hotels in Durham

Pool
Hot tub

Top Durham Hotel Reviews

La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

10/10 Excellent
"The room was clean, staff was great"
Kelly 2-night trip
Posted less than an hour ago
La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

Frequently asked questions

Looking to vacation at a spa hotel in Durham?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Travelers love the array of shops and restaurants in Durham. Spa hotels are a great way to break out of your routine and add a layer of luxury to your holiday.
What's there to see and do in Durham?
Experience Durham and visit Carolina Theatre, Durham Performing Arts Center, and American Tobacco Campus. If you have extra time while you're in the area, you might want to see Durham Bulls Athletic Park and Sarah P. Duke Gardens.
What is a Durham spa hotel?
Spa hotels in Durham provide lodging and have an on-site spa offering services including massages and beauty treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.