A historic stone fortress with a central dome and surrounding walls.

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Check availability on Colon Luxury Hotels

Tonight
Oct 14 - Oct 15
Tomorrow
Oct 15 - Oct 16
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Colon luxury hotels

A balcony with a table, chairs, and a view of a city skyline across a body of water.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.

1. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
  • Indulge in colonial elegance at this Panama City gem featuring a full-service spa, outdoor pool, and gourmet dining.
￥55,577
￥61,135 total
includes taxes & fees
Nov 3 - Nov 4
Sofitel Legend Casco Viejo, Panama City
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.
A modern hotel room with a dining area, a TV, and a city view.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.

2. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
  • Exclusive Panama City escape offers lavish poolside retreats and gourmet dining experiences.
￥18,627
￥20,490 total
includes taxes & fees
Oct 28 - Oct 29
Hotel Riu Plaza Panama
A poolside area with lounge chairs and a view of the ocean.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.
A terrace with seating and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.

3. JW Marriott Panama

JW Marriott Panama
San Francisco
  • Unwind in opulent waterfront luxury with 4 pristine pools and ocean-view dining in Panama City.
￥44,209
￥48,629 total
includes taxes & fees
Nov 7 - Nov 8
JW Marriott Panama
A restaurant with multiple dining tables, chairs, and a central water feature.
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.
A bar area with multiple seating options, a bar counter, and a fireplace.
A historic building with ornate stonework and a balcony with plants.

4. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
Casco Viejo
  • Experience historic luxury in Panama's Casco Viejo district with 5 restaurants and a rooftop pool with spectacular views.
￥38,896
￥42,786 total
includes taxes & fees
Oct 16 - Oct 17
Hotel La Compañía Casco Antiguo
A high-rise building with a modern architectural design, featuring a grid of windows and balconies.
A rooftop pool area with purple lounge chairs and a city skyline in the background.
An escalator in a hotel lobby with a patterned wall and framed artwork.
A rooftop lounge with modern seating and a panoramic city view.

5. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
  • Experience luxury and elegance in a Panamanian retreat with 2 restaurants, a spa, and casino.
￥25,294
￥27,823 total
includes taxes & fees
Oct 31 - Nov 1
Megapolis Hotel Panamá
A hotel entrance with a central water feature, seating areas, and potted plants.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.
A pool with a central water feature, surrounded by seating areas and potted plants.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

6. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
  • Elevate your Panama City escape with a Jack Nicklaus golf course, rejuvenating spa treatments, and poolside luxury at this 5-star retreat.
￥43,821
￥48,203 total
includes taxes & fees
Nov 1 - Nov 2
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.
A modern interior with a spiral staircase, a large window, and a seating area.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.

7. Hilton Panama

Hilton Panama
Bella Vista
  • Panama City sophistication meets relaxation with an attached winery, poolside dining, and a full-service spa offering couples' treatments.
￥40,377
￥44,415 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.

8. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
  • Panama City elegance at this Waldorf Astoria hotel with a full-service spa, outdoor pool, and refined dining in two upscale restaurants.
￥41,588
￥45,747 total
includes taxes & fees
Nov 7 - Nov 8
Waldorf Astoria Panama
A spacious indoor area with high ceilings, large windows, and multiple dining tables.
A restaurant with brick walls, arched windows, and a variety of seating arrangements including tables and chairs.
A white building with multiple balconies, large windows, and decorative railings.
A multi-story hotel with a central courtyard, balconies, and a view of the city skyline.

9. American Trade Hotel

American Trade Hotel
Casco Viejo
  • A colonial gem in Panama City offering luxurious comfort, exquisite dining, and personalized service in a historic district.
￥35,812
￥39,695 total
includes taxes & fees
Nov 2 - Nov 3
American Trade Hotel
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A high-rise building with a rooftop pool area, surrounded by other buildings.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.

10. W Panama

W Panama
Bella Vista
  • Lavish urban retreat offers 3 hot tubs, poolside luxury, and concierge services in Panama city.
￥36,608
￥40,269 total
includes taxes & fees
Nov 1 - Nov 2
W Panama
View all properties

Top Colon Hotel Reviews

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

8/10 Good
"Overall, we had a pleasant stay. Check-in was quick and smooth, and the staff were very helpful. The breakfast staff were especially friendly and attentive. The rooms were comfortable and well maintained, housekeeping was excellent, and the hotel was clean and well kept. The only disappointment was the dining options. The bar had a very limited food menu, and the dinner options at the hotel were not up to standard, with very little variety. The biggest advantage is the location, with Multiplaza Mall right next door, offering excellent shopping, restaurants, and everything you need within walking distance."
Gangawati 1-night trip
Posted 1 hour ago
Courtyard by Marriott Panama Multiplaza Mall
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Me encantó"
Josue Llauger 4-night trip
Posted 2 hours ago
Hotel Riu Plaza Panama
Hotel Ojos del Rio

Hotel Ojos del Rio

10/10 Excellent
"Place was nice and quiet and was a comfortable stay."
Sheridan 1-night trip
Posted 11 hours ago
Hotel Ojos del Rio

Frequently asked questions

Are you looking for a luxury hotel for your Colon vacation?
Use Expedia to arrange your flight to Panama City (PAC-Marcos A. Gelabert Intl.) airport or Balboa (BLB-Panama Pacifico Intl.) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Colon offers. Colon has some interesting things to see and do including Colon 2000 and Colon Free Zone, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Colon?
Sand Diamond Hotel is a luxury hotel with ski-in/ski-out access and a casino, and it's a popular choice for Expedia travelers looking for an elegant place to stay.
When can I expect good weather in Colon?
Planning for the weather is an important factor for making your trip to Colon a success, especially when you're splurging. The hottest months are usually May and September with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in Colon are November, July, August, and October, with each month seeing an average of 14 inches of rainfall.
What's there to see and do in Colon?
Take in the sights and attractions that Colon offers with a visit to Colon 2000, Colon Free Zone, and Gamboa Rainforest Resort. If you have extra time while you're in the area, you might want to see Fantastic Casino | Colón 2000 and Fort San Lorenzo.
How can I get around Colon?
It's easier to get around town in style when you know your options. To see more of the larger area, ride aboard one of the trains from Colon Atlantic Passenger Station.