A calm river with boats, lush greenery, and a clear blue sky.

Find 4 Star Hotels in Big Pine Key, FL from ￥35,271

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Check availability on Big Pine Key 4 Star Hotels

Next weekend
Jul 31 - Aug 2
In two weeks
Aug 7 - Aug 9

Our top choices for Big Pine Key 4-star hotels

2 bars/lounges, poolside bar

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.6 out of 10, Excellent, (1,172 reviews)
"Great location!"
United States
Frank
The price is ￥25,871
￥35,271 total
includes taxes & fees
Aug 21 - Aug 22
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
3 outdoor pools, sun loungers

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,004 reviews)
"Property was well maintained, staff was super helpful and kind!"
United States
Brittany
The price is ￥26,723
￥40,502 total
includes taxes & fees
Aug 25 - Aug 26
Tranquility Bay Beachfront Hotel and Resort
Balcony view

Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (477 reviews)
"Great location, beautiful room with sea view balcony. Would stay again"
United Kingdom
Katherine
The price is ￥31,876
￥43,725 total
includes taxes & fees
Jul 28 - Jul 29
Grassy Flats Resort & Beach Club
Exterior

Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.5 star property
Marathon
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful vacation!"
United States
Chardell
Marlin Bay Resort & Marina
Luxury Villa, 3 Bedrooms, Balcony, Overwater | Terrace/patio

Waterfront Luxury Villa

Waterfront Luxury Villa
4.0 star property
Marathon Shores
Waterfront Luxury Villa
Villa, 3 Bedrooms | Property grounds

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
4.0 star property
Marathon Shores
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Outdoor pool

Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Indigo Reef Marina Pet Friendly Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Pet Friendly Homes by Pack and Relax
Outdoor pool

Indigo Reef Marina Homes by Pack and Relax

Indigo Reef Marina Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Homes by Pack and Relax
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
The price is ￥36,471 per night from Aug 11 to Aug 12
￥36,471
￥50,923 total
Aug 11 - Aug 12
includes taxes & fees
9.2/10 Wonderful! (1,202 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colorful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A beach with clear turquoise water, a red umbrella, and a bridge in the background.

Top Big Pine Key Hotel Reviews

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent
"Excellent"
Bairon 3-night trip
Posted 1 hour ago
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

8/10 Good
"."
Jose 1-night trip
Posted 17 hours ago
Tranquility Bay Beachfront Hotel and Resort

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?
Create unforgettable vacation memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. A favorite with our guests, this 4-star hotel offers loads of conveniences for a relaxing and comfortable stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To find a 4-star hotel in Big Pine Key that fits your budget, use Expedia's handy filters. Take a look at the available options during your vacation dates and use our pricing filter to set your limit. You can also list your results by the most budget-friendly stay first.

  • Search for the lowest price from ￥50,923

What's the difference between 5-star and 4-star hotels in Big Pine Key?
Treat yourself to luxury living during your Big Pine Key getaway by checking in to a 4-star hotel. As well as featuring upscale accommodations, these retreats are usually packed with amenities like large beds, complimentary bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour concierge assistance, elegant furnishings and world-class dining are only the start of the exclusive services and conveniences you'll likely have access to.