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Find Luxury Hotels in South San Francisco, CA

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Check availability on South San Francisco Luxury Hotels

Our top choices for South San Francisco luxury hotels

View from property
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
4.0 star property
Oyster Point
9.2 out of 10, Wonderful, (1002)
"Very convenient stay for San Francisco. Clean hotel and very comfortable bed. Excellent gym. Will stay again. "
United States
Andy
The price is ￥18,090
￥21,635 total
includes taxes & fees
Dec 19 - Dec 20
AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront
Bar (on property)
DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd

DoubleTree by Hilton San Francisco South Airport Blvd
4.0 star property
South San Francisco
8.4 out of 10, Very Good, (2036)
"Room was clean, staff were helpful. Overall stay was good"
Australia
Jenny Faatoatuiga
The price is ￥17,879
￥21,074 total
includes taxes & fees
Dec 22 - Dec 23
DoubleTree by Hilton San Francisco South Airport Blvd
View from property
The Ritz-Carlton, Half Moon Bay

The Ritz-Carlton, Half Moon Bay

The Ritz-Carlton, Half Moon Bay
5.0 star property
Ocean Colony
9.0 out of 10, Wonderful, (647)
"The staff throughout the resort were extremely friendly and helpful."
United States
Steve
The price is ￥120,387
￥152,600 total
includes taxes & fees
Jan 15 - Jan 16, 2026
The Ritz-Carlton, Half Moon Bay
Exterior
InterContinental San Francisco by IHG

InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1027)
"Love this hotel in SF."
United States
JONATHAN
The price is ￥24,306
￥35,025 total
includes taxes & fees
Dec 21 - Dec 22
InterContinental San Francisco by IHG
Breakfast, lunch, dinner served; alfresco dining
1 Hotel San Francisco

1 Hotel San Francisco

1 Hotel San Francisco
5.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (486)
"The staff was incredible and we loved all of the design touches in the room. The attention to detail was impressive. "
United States
Eric
The price is ￥55,936
￥74,635 total
includes taxes & fees
Dec 22 - Dec 23
1 Hotel San Francisco
3 outdoor pools, open 6:00 AM to 9:00 PM, pool umbrellas, sun loungers
Claremont Resort & Club

Claremont Resort & Club

Claremont Resort & Club
5.0 star property
Claremont Hills
8.8 out of 10, Excellent, (1008)
"Everything about our stay with you was excellent !!!!"
United States
Gene
The price is ￥39,945
￥55,295 total
includes taxes & fees
Dec 17 - Dec 18
Claremont Resort & Club
Terrace/patio
Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco
5.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1003)
"The staff is fantastic"
United States
Brandon
The price is ￥59,987
￥70,601 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Four Seasons Hotel San Francisco
Sundeck
Hotel VIA

Hotel VIA

Hotel VIA
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1500)
"Smooth check in and check out. Nice room and friendly staff in a great location "
United States
Nancy
The price is ￥25,101
￥29,542 total
includes taxes & fees
Dec 21 - Dec 22
Hotel VIA
Outdoor pool
Rosewood Sand Hill

Rosewood Sand Hill

Rosewood Sand Hill
5.0 star property
Menlo Park
9.4 out of 10, Exceptional, (276)
"Really great hotel and my go to place for anything in Palo Alto "
United States
Lisa
The price is ￥129,712
￥159,735 total
includes taxes & fees
Dec 19 - Dec 20
Rosewood Sand Hill
Breakfast, lunch and dinner served
The Jay, Autograph Collection

The Jay, Autograph Collection

The Jay, Autograph Collection
4.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (324)
"Loved my stay"
United States
Christina
The price is ￥41,913
￥49,330 total
includes taxes & fees
Dec 19 - Dec 20
The Jay, Autograph Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top South San Francisco Hotel Reviews

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

10/10 Excellent
"Great customer service!"
Claudia 1-night trip
Posted 2 days ago
La Quinta Inn & Suites by Wyndham San Francisco Airport N

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Frequently asked questions

Are you searching for a great accommodation for your luxury trip to South San Francisco?
Let Expedia help you arrange your flight to San Francisco Intl. Airport (SFO) airport or Oakland Intl. Airport (OAK) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that South San Francisco offers. Known for its sightseeing and tours, South San Francisco also has some interesting things to see and do including San Francisco Bay, so you may want to take in the local sights during your visit.
When can I expect good weather in South San Francisco?
Planning for the weather is an important factor for making your trip to South San Francisco a success, especially when you're splurging. The hottest months are usually September and August with an average temp of 62°F, while the coldest months are February and January with an average of 53°F. Average annual precipitation for South San Francisco is 23 inches.
What's there to see and do in South San Francisco?
Take in some sights and attractions while you're in South San Francisco by visiting San Francisco Bay, Santa Cruz Mountains, and See's Candies. If you have spare time during your trip, you might want to make a stop at San Bruno Point Park and K1 Speed.
How can I get around South San Francisco?
It's easier to get around town in style when you know your options. Make your way to South San Francisco Metro Station to catch metro. To see more of the larger area, hop on a train at South San Francisco Station.