Search Vacation Homes in South Carolina Midlands
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
In two weeks
In two months
In three months
In four months
Our top choices for South Carolina Midlands vacation homes
Vacation Home in Lexington
The Turquoise Door in Town of Lexington9.8 out of 10, Exceptional, (119 reviews)
"Very cozy place! Perfect location right in the middle of everything!"
Noah
The price is ￥12,612
￥43,204 total
includes taxes & fees
Jan 26 - Jan 27
Vacation Home in Hollands Landing
The Last Resort at Martins Landing9.8 out of 10, Exceptional, (36 reviews)
"Great place to stay for a Lake Murray get away!!"
Travis D.
The price is ￥17,516
￥35,903 total
includes taxes & fees
Jan 25 - Jan 26
Vacation Home in Florence
Walking distance from one of South Carolina's top Medical centers.9.8 out of 10, Exceptional, (42 reviews)
"The house was beautiful. We would stay there again!!"
Stephanie L.
The price is ￥21,258
￥36,237 total
includes taxes & fees
Jan 27 - Jan 28
Vacation Home in Santee
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!10.0 out of 10, Exceptional, (37 reviews)
"Great house, very modern interior. Very clean. Close to town. We’ll definitely book the house on our fishing trip. "
John H.
The price is ￥13,125
￥48,175 total
includes taxes & fees
Jan 27 - Jan 28
Vacation Home in Mullins
Peaceful Farm Getaway10.0 out of 10, Exceptional, (32 reviews)
"Excellent Space. Loved It."
Rodney
The price is ￥21,020
￥32,246 total
includes taxes & fees
Feb 22 - Feb 23
Vacation Home in Columbia
1972 Airstream luxury tiny living at it's best in Columbia near Lake Murray!9.8 out of 10, Exceptional, (30 reviews)
"We enjoy our stay at this quaint quiet place. Loved the outdoor sitting area and the airstream was clean an cutely decorated."
Marian A.
The price is ￥16,977
￥25,184 total
includes taxes & fees
Jan 26 - Jan 27
Vacation Home in Old Town Rock Hill
The Little Lemon Studio | King Bed | Office Space | Walk to Winthrop9.0 out of 10, Wonderful, (8 reviews)
"Will return to this location, Very very well kept and nice."
Carlos Mario
The price is ￥9,416
￥46,541 total
includes taxes & fees
Jan 25 - Jan 26
Vacation Home in Old Town Rock Hill
Boho Bliss |2 Bd/1Bth Top Floor Unit | King Beds | 5 Min. Walk to Winthrop9.4 out of 10, Exceptional, (19 reviews)
"My daughters loved the big comfy beds. Nice stay. Will visit this place again. Highly recommend. "
Melissa L.
The price is ￥12,729
￥55,412 total
includes taxes & fees
Jan 26 - Jan 27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find vacation rentals that suit your style
Cabins
Aparthotels
Save an average of 15% on thousands of hotels when you're signed in
Top South Carolina Midlands Hotel Reviews
Wyndham Garden Columbia/Ft. Jackson
10/10 Excellent
Find out more about South Carolina Midlands
South Carolina Midlands Vacation Homes information
Number of reviews | 480 |
|---|---|
Accommodation | 837 Vacation Homes |
Lowest Price | ￥21,115 |
Highest Price | ￥67,314 |
Explore a world of travel with Expedia
- Town Houses in Lancaster
- Columbia Hotels
- Cottages in Camden
- Beach Hotels in South Carolina
- Rv Parks in Sumter
- East Sumter Hotels
- Orangeburg Hotels
- Blythewood Hotels
- Cheap Hotels in Columbia
- Romantic Hotels in South Carolina
- South Carolina Hotels
- Boutique Hotels in Downtown Columbia
- Ranches in South Carolina
- Hotels near Shaw Air Force Base
- Cheap Hotels in Camden
- Lexington Hotels
- West Columbia Hotels
- Hostels in Rock Hill
- B&B in Carlisle
- Cottages in Gable
- Hotels with a Pool in Bishopville
- Lancaster Hotels
- Motels in Cameron
- Aparthotels in South Carolina
- Vacation Homes in Rock Hill
- Historic Hotels in Rosewood
- Hotels near Lake Murray
- Resorts in Pinewood
- Luxury Hotels in Summerton
- Lodges in Leesville
- Swansea Hotels
- Aparthotels in Gilbert
- Aparthotels in Camden
- Romantic Hotels in South Carolina Midlands
- Pet-Friendly Hotels in Sumter
- Business Hotels in Columbia
- Hotels near South Carolina State University
- Hotels near Shaw Air Force Base
- Salley Hotels
- Rv Parks in Springdale
- Sumter Hotels
- Aparthotels in Columbia
- Pageland Hotels
- Pomaria Hotels
- Aparthotels in West Columbia
- Capsule Hotels in Columbia
- Aparthotels in Lando
- Treehouses in South Carolina
- Cheap Hotels in Carlisle
- Hotels near Congaree National Park
- Hotels near Williams Brice Stadium
- Rv Parks in South Carolina
- Downtown Columbia Hotels
- Rock Hill Hotels
- Resorts & Hotels with Spas in Lake Carolina
- Cabin Rentals in South Carolina Midlands
- Cheap Hotels in Downtown Columbia
- Hotels near Riverbanks Zoo and Garden
- Pet-Friendly Hotels in Downtown Columbia
- Hotels near Columbia Metropolitan
- Hotels near Fort Jackson
- Golf Hotels in Denmark
- Hostels in South Carolina
- Irmo Hotels
- Golf Hotels in Rock Hill
- Rv Parks in South Congaree
- Luxury Hotels in Columbia
- Hotels near Columbia Metropolitan Convention Center
- All-Inclusive Hotel Hotels in South Carolina
- Town Houses in Columbia
- Hotels near South Carolina State Fairgrounds
- Hostels in Columbia
- Cheap Hotels in Orangeburg
- Adults Only Resorts & in South Carolina
- Cheap Hotels in Blackstock
- All-Inclusive Hotel Hotels in Lake Carolina
- B&B in Columbia
- Aparthotels in South Carolina Midlands
- Rv Parks in Prosperity
- Aparthotels in Rock Hill