A monument with a statue on top, in front of a large building with columns.

Search Guest Houses in South Carolina Midlands

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25
In one month
Nov 6 - Nov 8
In two months
Dec 4 - Dec 6

Our top choices for South Carolina Midlands guest houses

A covered porch with wooden railings and a ceiling fan.

1. 818 Queen St · Relaxing Cozy Apartment in Downtown Cola

818 Queen St · Relaxing Cozy Apartment in Downtown Cola
Downtown Columbia
9.6 out of 10, Exceptional, (10 reviews)
"Great walkable location. Perfect stay for my husband and I visiting our son at USC.Cute place!"
United States
Kristen Y.
The price is ￥14,364
￥38,761 total
includes taxes & fees
Oct 6 - Oct 7
818 Queen St · Relaxing Cozy Apartment in Downtown Cola
A cozy living room with a wooden bench, a piano, and a large window with curtains.

2. Amazing Studio Guesthouse, in beautiful Columbia Lake community suburb.

Amazing Studio Guesthouse, in beautiful Columbia Lake community suburb.
Lake Carolina
10.0 out of 10, Exceptional, (22 reviews)
"Always a pleasure staying at this property "
United States
Lee Y.
The price is ￥27,624
￥35,005 total
includes taxes & fees
Nov 2 - Nov 3
Amazing Studio Guesthouse, in beautiful Columbia Lake community suburb.
A modern kitchen with white cabinetry, a black countertop, and a round dining table.

3. The Wren`s Nest | 1BR 2BA Guesthouse

The Wren`s Nest | 1BR 2BA Guesthouse
Eau Claire
9.2 out of 10, Wonderful, (9 reviews)
"We loved the property and will definitely stay again if the opportunity arises."
United States
Holly K.
The Wren`s Nest | 1BR 2BA Guesthouse
Dining

4. BlueHeronLake-Guesthouse Studio

BlueHeronLake-Guesthouse Studio
Columbia
The price is ￥11,050
￥43,070 total
includes taxes & fees
Oct 18 - Oct 19
BlueHeronLake-Guesthouse Studio
A two-story house with a porch, large windows, and a covered front entrance.

5. Burch's Carriage House

Burch's Carriage House
Society Hill
10.0 out of 10, Exceptional, (37 reviews)
"Great location and great setup for me. "
United States
Steve M.
The price is ￥16,732
￥28,561 total
includes taxes & fees
Oct 29 - Oct 30
Burch's Carriage House
A two-story house with a covered patio and a garage.

6. Luxury Carriage House Suite on the Lake.

Luxury Carriage House Suite on the Lake.
Fort Mill
10.0 out of 10, Exceptional, (23 reviews)
"This was everyone I needed it to be will definitely be back"
United States
Jovon B.
The price is ￥29,842
￥37,329 total
includes taxes & fees
Oct 6 - Oct 7
Luxury Carriage House Suite on the Lake.
A cozy living room with a fireplace, a large sofa, a patterned rug, and a bookshelf.

7. The Queen Anne Inn

The Queen Anne Inn
2.5 star property
Olde Town Augusta
8.0 out of 10, Very good, (92 reviews)
"We had the best experience & we definitely will be returning in the future"
United States
Kimberly
The price is ￥22,417
￥27,176 total
includes taxes & fees
Oct 8 - Oct 9
The Queen Anne Inn
A bedroom with a bed, a ceiling fan, a painting, and a door.

8. 1 bedroom, 1 bathroom sleeps max 4 guests with the sleeping arrangements being a king bed and futon that sleeps 2

1 bedroom, 1 bathroom sleeps max 4 guests with the sleeping arrangements being a king bed and futon that sleeps 2
Summerville
9.8 out of 10, Exceptional, (9 reviews)
"Nice, clean and immaculate! "
United States
Hayley M.
The price is ￥9,471
￥40,596 total
includes taxes & fees
Oct 15 - Oct 16
1 bedroom, 1 bathroom sleeps max 4 guests with the sleeping arrangements being a king bed and futon that sleeps 2
A dining area with a wooden table, black chairs, a ceiling fan, and a vase of flowers.

9. 1 bed 1 bath home that sleeps max 4 guests with sleeping arrangements being a queen bed and a fold out couch that is queen sized.

1 bed 1 bath home that sleeps max 4 guests with sleeping arrangements being a queen bed and a fold out couch that is queen sized.
Summerville
9.0 out of 10, Wonderful, (6 reviews)
"We had a great experience during our stay. This home had everything you could possible need and had a lot of cute welcoming touches! I definitely recommend this home to anyone visiting. "
United States
Roxanne V.
1 bed 1 bath home that sleeps max 4 guests with sleeping arrangements being a queen bed and a fold out couch that is queen sized.
A modern kitchen with white cabinets, stainless steel appliances, and a wooden floor.

10. Rooftop Patio Oasis - 5 minutes outside Uptown

Rooftop Patio Oasis - 5 minutes outside Uptown
Biddleville
10.0 out of 10, Exceptional, (12 reviews)
"Stayed here as an overnight getaway to celebrate several things with my wife. It was a very nice, very cozy place. We loved it so much!"
United States
Matthew C.
The price is ￥16,890
￥62,059 total
includes taxes & fees
Oct 28 - Oct 29
Rooftop Patio Oasis - 5 minutes outside Uptown
A modern living room with a white sofa, a wooden coffee table, and a fireplace. There is a large window providing natural light and a view of trees outside.

11. Adorable 2-br guest suite minutes from SouthPark/Uptown

Adorable 2-br guest suite minutes from SouthPark/Uptown
Charlotte
9.0 out of 10, Wonderful, (17 reviews)
"Everything was great and the location was perfect for our stay. "
United States
Jimmy H.
The price is ￥22,257
￥49,914 total
includes taxes & fees
Oct 6 - Oct 7
Adorable 2-br guest suite minutes from SouthPark/Uptown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top South Carolina Midlands Hotel Reviews

Quality Inn Columbia Airport

Quality Inn Columbia Airport

8/10 Good
"The staff was consistently excellent. The room smelled of 1974. I accidentally got a smoking room. It is a very affordable and nice place. Worth it"
Matt 3-night trip
Posted less than an hour ago
Quality Inn Columbia Airport

Find out more about South Carolina Midlands

South Carolina Midlands Guest Houses information

Number of reviews
215
Accommodation
8 Guest Houses
Lowest Price
￥27,176
Highest Price
￥62,059

Explore a world of travel with Expedia