Find hotels in Serin, Lyon

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 21 - Dec 22
Tomorrow
Dec 22 - Dec 23
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Serin hotels

Sauna, hot tub, steam room, massage/treatment rooms, massages
Hotel Lyon Métropole

Hotel Lyon Métropole

Hotel Lyon Métropole
4.0 star property
Serin
8.6 out of 10, Excellent, (1000)
"It is worth paying for spa/pool. It is amazing! Nice clean hotel and polite staff"
Norway
Anonymous traveler
The price is ￥21,229
￥24,409 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Lyon Métropole
Indoor pool
Grand Hotel Des Terreaux

Grand Hotel Des Terreaux

Grand Hotel Des Terreaux
4.0 star property
1.9 km from Serin
8.8 out of 10, Excellent, (1003)
"helpful staff, hotel location, amenities"
Canada
Rick
The price is ￥17,418
￥20,217 total
includes taxes & fees
Dec 24 - Dec 25
Grand Hotel Des Terreaux
Deluxe Room, River View | 1 bedroom, premium bedding, Select Comfort beds, in-room safe
Le Phenix Hotel

Le Phenix Hotel

Le Phenix Hotel
4.0 star property
Old Lyon, 1.7 km from Serin
9.2 out of 10, Wonderful, (1001)
"Fantastic location with excellent rooms"
United States
Hudson
The price is ￥19,096
￥22,062 total
includes taxes & fees
Dec 25 - Dec 26
Le Phenix Hotel
Exterior
Hotel Silky by HappyCulture

Hotel Silky by HappyCulture

Hotel Silky by HappyCulture
4.0 star property
Les Cordeliers, 2.3 km from Serin
8.8 out of 10, Excellent, (971)
"Amazing location and hotel. Perfect for seeing the sites and coming back and feeling welcomed by the staff. Great breakfast too!"
Canada
Cameron
The price is ￥16,625
￥19,345 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hotel Silky by HappyCulture
View from property
Fourvière Hôtel Lyon

Fourvière Hôtel Lyon

Fourvière Hôtel Lyon
4.0 star property
Fourvière, 2.3 km from Serin
9.2 out of 10, Wonderful, (1000)
"This property was excellent "
United States
Ed
Fourvière Hôtel Lyon
Daily buffet breakfast (EUR 20 per person)
OKKO Hotels Lyon Centre

OKKO Hotels Lyon Centre

OKKO Hotels Lyon Centre
4.0 star property
2.6 km from Serin
9.0 out of 10, Wonderful, (1000)
"Fantastic hotel, welcoming staff. "
Canada
Carol
The price is ￥17,348
￥20,140 total
includes taxes & fees
Dec 25 - Dec 26
OKKO Hotels Lyon Centre
Terrace/patio
Maison Nô

Maison Nô

Maison Nô
4.0 star property
2.1 km from Serin
9.0 out of 10, Wonderful, (402)
"Spotless room, comforting decor, wonderful staff"
United Kingdom
Andrew
Maison Nô
Exterior
Best Western Hotel Saint Antoine

Best Western Hotel Saint Antoine

Best Western Hotel Saint Antoine
3.0 star property
Les Cordeliers, 2.4 km from Serin
8.2 out of 10, Very Good, (435)
"Really great location and helpful staff. Really cramped room, though one of the two the best showers we have had of 20 different hotel rooms on this trip. "
United States
Fred
The price is ￥11,406
￥13,237 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Best Western Hotel Saint Antoine
Exterior
Hôtel Mercure Lyon Centre Plaza République

Hôtel Mercure Lyon Centre Plaza République

Hôtel Mercure Lyon Centre Plaza République
4.0 star property
Les Cordeliers, 2.7 km from Serin
8.4 out of 10, Very Good, (686)
"Location excellent"
United States
DIDEM
The price is ￥17,128
￥19,898 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hôtel Mercure Lyon Centre Plaza République
Prestigieuse Double Room | Premium bedding, pillowtop beds, individually decorated
Hôtel Bayard Bellecour

Hôtel Bayard Bellecour

Hôtel Bayard Bellecour
4.0 star property
Bellecour - Hôtel Dieu, 2.9 km from Serin
8.6 out of 10, Excellent, (420)
"Very good hotel in a central area, quiet room and very nice staff! "
United States
Sandrine
Hôtel Bayard Bellecour
In-room safe, desk, blackout drapes, free WiFi
Hôtel des Célestins

Hôtel des Célestins

Hôtel des Célestins
3.0 star property
Bellecour - Hôtel Dieu, 2.6 km from Serin
9.0 out of 10, Wonderful, (394)
"This is the perfect location and a beautiful smaller hotel, highly recommend."
United States
Steven
The price is ￥16,251
￥18,567 total
includes taxes & fees
Dec 22 - Dec 23
Hôtel des Célestins
Single Room (Act I) | Premium bedding, in-room safe, individually furnished, desk
Hôtel des Artistes

Hôtel des Artistes

Hôtel des Artistes
3.0 star property
Bellecour - Hôtel Dieu, 2.5 km from Serin
9.0 out of 10, Wonderful, (1000)
"Great location, comfortable room, excellent value "
United States
Glen
The price is ￥16,420
￥18,753 total
includes taxes & fees
Dec 25 - Dec 26
Hôtel des Artistes
Balcony
Hôtel Alexandra

Hôtel Alexandra

Hôtel Alexandra
4.0 star property
2nd Arrondissement, 3.1 km from Serin
8.4 out of 10, Very Good, (659)
"Fine place to stay "
United Kingdom
Michael
Hôtel Alexandra
Daily buffet breakfast (EUR 17 per person)
Hotel Charlemagne By HappyCulture

Hotel Charlemagne By HappyCulture

Hotel Charlemagne By HappyCulture
4.0 star property
3.8 km from Serin
8.4 out of 10, Very Good, (1003)
"The room was very clean, spacious and had so many great amenities."
United Kingdom
Ella
The price is ￥16,121
￥18,790 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hotel Charlemagne By HappyCulture
3ème Cycle Double Room | Terrace/patio
Collège Hôtel

Collège Hôtel

Collège Hôtel
4.0 star property
Old Lyon, 1.8 km from Serin
8.4 out of 10, Very Good, (765)
"Loved it"
United States
Steven
Collège Hôtel
Restaurant
Le Royal Hotel Lyon - MGallery Collection

Le Royal Hotel Lyon - MGallery Collection

Le Royal Hotel Lyon - MGallery Collection
5.0 star property
Bellecour - Hôtel Dieu, 2.9 km from Serin
9.0 out of 10, Wonderful, (1000)
"Great staff and excellent location "
United States
Dana
The price is ￥32,267
￥36,956 total
includes taxes & fees
Dec 24 - Dec 25
Le Royal Hotel Lyon - MGallery Collection
Reception
Campanile Lyon Centre-Berges du Rhône

Campanile Lyon Centre-Berges du Rhône

Campanile Lyon Centre-Berges du Rhône
3.0 star property
3rd Arrondissement, 3.2 km from Serin
7.8 out of 10, Good, (1000)
"Good stay for one night in Lyon. Good basic hotel. "
United Kingdom
Olivia
The price is ￥11,013
￥12,806 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Campanile Lyon Centre-Berges du Rhône
Breakfast, lunch, dinner served; Regional cuisine
Radisson Blu Hotel Lyon

Radisson Blu Hotel Lyon

Radisson Blu Hotel Lyon
4.0 star property
Part Dieu - Bir Hakeim, 3.6 km from Serin
8.4 out of 10, Very Good, (1004)
"It was great. The room was clean and comfortable. The staff were helpful and friendly"
United States
Glenn
The price is ￥20,487
￥23,593 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Radisson Blu Hotel Lyon
Buffet breakfast on weekends (EUR 20 per person)
Mercure Lyon Centre Beaux Arts

Mercure Lyon Centre Beaux Arts

Mercure Lyon Centre Beaux Arts
4.0 star property
Les Cordeliers, 2.5 km from Serin
9.0 out of 10, Wonderful, (1000)
"Relatively basic hotel in a great location with excellent staff."
United Kingdom
Ian
The price is ￥19,063
￥22,026 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Mercure Lyon Centre Beaux Arts
Suite Luxe Bellecour, 5 place Bellecour, 69002 Lyon | Premium bedding, pillowtop beds, minibar, in-room safe
MiHotel

MiHotel

MiHotel
Bellecour - Hôtel Dieu, 2.6 km from Serin
8.2 out of 10, Very Good, (543)
"This was the loveliest hotel that we stayed in on our European vacation, clean and modern. I would recommend MiHotel to anyone staying in the Lyon area"
Australia
Lachlan
The price is ￥19,748
￥22,809 total
includes taxes & fees
Dec 22 - Dec 23
MiHotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Serin

Find the best Serin areas and neighborhoods for the activities you enjoy most.
Textile Museum

Lyon City Centre

Lyon City Centre is highly notable for its popular shops, and you might want to visit top sights like Bellecour Square and Place Carnot. See more of Lyon by jumping on the metro at Saint-André Tram Stop or Rue de l'Universite Tram Stop.

Lyon showing a city, a statue or sculpture and a river or creek

Old Lyon

Explore the largest Renaissance district in Lyon, a UNESCO World Heritage site, featuring three sections: Saint Jean, Saint Paul, and Saint Georges. Discover museums, traboules, and historic churches, with Gare Saint-Paul as a transportation hub.

Bellecour Square showing a statue or sculpture, a bridge and a river or creek

Bellecour - Hôtel Dieu

While you're in Bellecour - Hôtel Dieu, take in top sights like Bellecour Square and jump on the metro at Bellecour Station to see more of the city.

3rd Arrondissement

Discover the 3rd arrondissement's impressive towers, such as Tour Part-Dieu and Tour Oxygène, and enjoy cultural venues like Auditorium Maurice-Ravel and Théâtre de la Tête d'Or. Easily navigate with Metro Lines B and D, and Tramway T1 and T3.

Confluence Museum

2nd Arrondissement

Lively and commercial, the 2nd arrondissement boasts notable places like Place Bellecour and Musée des Confluences. Easily accessible via metro and tram lines, it's also home to Lyon-Perrache station.

Top Serin Hotel Reviews

Campanile Lyon Centre-Berges du Rhône

Campanile Lyon Centre-Berges du Rhône

10/10 Excellent
"Très propre. Accueil disponible et souriant. Peut déjeuner agréable "
Daniel 2-night trip
Posted 7 days ago
Campanile Lyon Centre-Berges du Rhône

Frequently asked questions

What is Serin like?
You'll be sure to have fun visiting Lyon's Serin neighborhood. Consider a visit to Historic Site of Lyon as part of your Serin travel plans.
What's a favorite hotel to stay in Serin?
Based on Expedia customer reviews, Hotel Lyon Métropole is the highest ranked property in Serin. This hotel offers a full-service spa and a restaurant.
If I need to cancel my hotel reservation in Serin, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in Serin.
Where can I learn more about changing or cancelling my trip to Serin?
For more details about picking new dates or cancelling your trip to Serin, head over to our customer service page.
What is there to do in this Lyon neighborhood?
Historic Site of Lyon is an attraction you might want to check out while you're in Serin. While you're out sightseeing, Mur des Canuts and Le Jardin Des Chartreux are a couple of additional sights to visit in Lyon.

Explore a world of travel with Expedia